OMIA 001041-9031 : Ventricular septal defect in Gallus gallus

In other species: cattle , dog , pig , sheep , horse , domestic cat , rabbit , alpaca , turkey

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 614429 (trait) , 614431 (trait) , 614432 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A congenital heart defect characterised by persistent patency (open-ness) of the ventricular septum, permitting flow of blood directly between ventricles, bypassing the pulmonary circulation and resulting in various degrees of cyanosis (blue discolouration of the skin) due to oxygen deficiency. Clinical signs include systolic murmur and a palpable thrill on both sides of the chest, dyspnoea and poor tolerance of exercise.


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2011 Pourlis, A.F. :
Developmental malformations in avian species. Manifestations of unknown or genetic etiology - A review. Asian J Anim Vet Adv 6:401-415, 2011. DOI: 10.3923/ajava.2011.401.415.
1993 Bruyere, H.J., Stith, C.E. :
Strain-dependent effect of ethanol on ventricular septal defect frequency in white leghorn chick embryos. Teratology 48:299-303, 1993. Pubmed reference: 8278929. DOI: 10.1002/tera.1420480403.
1966 Siller, W.G., Hemsley, L.A. :
The incidence of congenital heart disease in seven flocks of broiler chickens. Vet Rec 79:451-4, 1966. Pubmed reference: 6008407. DOI: 10.1136/vr.79.16.451.
1958 SILLER, W.G. :
Ventricular septal defects in the fowl. J Pathol Bacteriol 76:431-40, 1958. Pubmed reference: 13588478. DOI: 10.1002/path.1700760212.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 26 Aug 2021