OMIA 001041-9031 : Ventricular septal defect in Gallus gallus

In other species: cattle , dog , pig , sheep , horse , domestic cat , rabbit , alpaca

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 614429 , 614431 , 614432

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: A congenital heart defect characterised by persistent patency (open-ness) of the ventricular septum, permitting flow of blood directly between ventricles, bypassing the pulmonary circulation and resulting in various degrees of cyanosis (blue discolouration of the skin) due to oxygen deficiency. Clinical signs include systolic murmur and a palpable thrill on both sides of the chest, dyspnoea and poor tolerance of exercise.


1993 Bruyere, H.J., Stith, C.E. :
Strain-Dependent Effect of Ethanol on Ventricular Septal Defect Frequency in White Leghorn Chick Embryos Teratology 48:299-303, 1993. Pubmed reference: 8278929. DOI: 10.1002/tera.1420480403.

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  • Created by Frank Nicholas on 06 Sep 2005