OMIA 001607-749190 : Skin colour in Cyprinus carpio 'color'
In other species: Garter snake , gilthead seabream , Nile tilapia , White's rock-skink , rainbow trout Mendelian trait/disorder: unknown Considered a defect: no Species-specific name: black patches Species-specific description: Chen et al. (2021): "three Tyrp1 genes were identified in Oujiang-color common carp (Cyprinus carpio var. color). The similar expression patterns and close phylogenetic relationship indicated that Tyrp1c is homologous to Tyrp1b and possibly originated from the ancient Tyrp1b. The rates of synonymous and non-synonymous substitution (Ka /Ks ) in Tyrp1 across teleost phylogeny indicated that Tyrp1a is more likely to be in the process of purifying selection. The CRISPR/Cas9 system was used to disrupt the Tyrp1 genes in zebrafish and the WB (black patches on white skin) strain of Oujiang-color common carp. The Tyrp1 loss of function variants in zebrafish and WB carp showed severe melanin deficiency in the skin. Meanwhile, inactivation of a single Tyrp1 gene did not obstruct melanin synthesis, which proved that the functional redundancy of Tyrp1 genes existed in both zebrafish and Oujiang-color common carp. Among the mosaic individuals with Tyrp1 genes in disrupted-color common carp, various mutations in Tyrp1b gene induced gray or brown phenotypes, suggesting that it may be bifunctional in Oujiang-color common carp. In addition, the phenotype of WB variants was different from that of WW (whole white skin), suggesting that Tyrp1 genes were not the key factor that caused the difference between WB and WW." This study involves use of CRISPR/Cas9 (GMO).
|2021||Chen, H., Wang, J., Du, J., Mandal, B.K., Si, Z., Xu, X., Yang, H., Wang, C. :|
|Analysis of recently duplicated TYRP1 genes and their effect on the formation of black patches in Oujiang-color common carp (Cyprinus carpio var. color). Anim Genet 52:451-460, 2021. Pubmed reference: 33939849. DOI: 10.1111/age.13071.|
- Created by Imke Tammen2 on 17 Jun 2021
- Changed by Imke Tammen2 on 17 Jun 2021