OMIA 001607-8128 : Skin colour in Oreochromis niloticus |
Wang et al. (2022) "found that most fishes have two pmel genes arising from the teleost-specific whole genome duplication. Both pmela and pmelb were expressed at high levels in the eyes and skin of Nile tilapia. We mutated both genes in tilapia using CRISPR/Cas9. ... our results indicate that, while both pmel genes are important for the formation of body color in tilapia, pmela plays a more important role than pmelb. ... Studies on these mutants suggest new strategies for breeding golden tilapia, and also provide a new model for studies of pmel function in vertebrates."
Inheritance: CRISPR/Cas9 gene editing was used to create mutations (GMO).References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2022 | Wang, C., Xu, J., Kocher, T.D., Li, M., Wang, D. : | |
CRISPR knockouts of pmela and pmelb engineered a golden tilapia by regulating relative pigment cell abundance. J Hered :, 2022. Pubmed reference: 35385582. DOI: 10.1093/jhered/esac018. | ||
2021 | Wang, C., Lu, B., Li, T., Liang, G., Xu, M., Liu, X., Tao, W., Zhou, L., Kocher, T.D., Wang, D. : | |
Nile tilapia: A model for studying teleost color patterns. J Hered 112:469-484, 2021. Pubmed reference: 34027978. DOI: 10.1093/jhered/esab018. |
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- Created by Imke Tammen2 on 26 May 2021
- Changed by Imke Tammen2 on 26 May 2021
- Changed by Imke Tammen2 on 14 Apr 2022