OMIA:002229-9749 : Hypotrichosis, HR-related in Delphinapterus leucas |
In other species: domestic cat , sheep , bottlenosed dolphin , long-beaked common dolphin , Indo-Pacific finless porpoise , Yangtze River dolphin , minke whale , Omura's baleen whale , pig
Categories: Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 203655 (trait) , 602302 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2013
Cross-species summary: Also known as Hairless
Molecular basis: Chen et al. (2013) reported evidence that the HR gene in cetaceans, including Delphinapterus leucas, has degenerated into a non-functional pseudogene, which is consistent with the hairlessness of this species.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| HR | Delphinapterus leucas | - | no genomic information (-..-) | HR | Ensembl |
Reference
| 2013 | Chen, Z., Wang, Z., Xu, S., Zhou, K., Yang, G. : |
| Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans. BMC Evol Biol 13:34, 2013. Pubmed reference: 23394579 . DOI: 10.1186/1471-2148-13-34. |
Edit History
- Created by Frank Nicholas on 27 Jan 2020