OMIA 002229-9749 : Hypotrichosis, HR-related in Delphinapterus leucas

In other species: domestic cat , sheep , bottlenosed dolphin , long-beaked common dolphin , Indo-Pacific finless porpoise , Yangtze River dolphin , minke whale , Omura's baleen whale

Possibly relevant human trait(s) and/or gene(s) (MIM number): 146550

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2013

Cross-species summary: Also known as Hairless

Molecular basis: Chen et al. (2013) reported evidence that the HR gene in cetaceans, including Delphinapterus leucas, has degenerated into a non-functional pseudogene, which is consistent with the hairlessness of this species.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
HR Delphinapterus leucas - no genomic information (-..-) HR Ensembl

Reference


2013 Chen, Z., Wang, Z., Xu, S., Zhou, K., Yang, G. :
Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans. BMC Evol Biol 13:34, 2013. Pubmed reference: 23394579. DOI: 10.1186/1471-2148-13-34.

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  • Created by Frank Nicholas on 27 Jan 2020