OMIA:003066-8090 : Genetically engineered gene knockout or knockin, generic in Oryzias latipes (Japanese medaka) |
In other species: grass carp , Nile tilapia , pig , golden hamster , turquoise killifish
Categories: Cellular phene
Single-gene trait/disorder: unknown
Disease-related: unknown
Cross-species summary: Gene knockout and knockin models comprise genetically engineered animals in which specific genes have been inactivated or deleted or added. These models provide a valuable tool for investigating gene function, disease mechanisms, and biological processes. See also gene specific entries (by doing an exhaustive search for GMO) and/or entires for OMIA:002665 Genetically engineered humanised animal.
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated genes:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| cyp19a1a | cytochrome P450, family 19, subfamily A, polypeptide 1a | Oryzias latipes | 3 | NC_136239.1 (16815524..16818210) | cyp19a1a | Ensembl, NCBI gene |
| cyp19a1b | cytochrome P450, family 19, subfamily A, polypeptide 1b | Oryzias latipes | 6 | NC_136242.1 (18394775..18390947) | cyp19a1b | Ensembl, NCBI gene |
| cyp1a | cytochrome P450, family 1, subfamily A | Oryzias latipes | 3 | NC_136239.1 (35096327..35093183) | cyp1a | Ensembl, NCBI gene |
| nphp4 | nephronophthisis 4 | Oryzias latipes | 7 | NC_136243.1 (36005046..36098323) | nphp4 | Ensembl, NCBI gene |
| bmal1a | basic helix-loop-helix ARNT like 1a | Oryzias latipes | 6 | NC_136242.1 (1244001..1211798) | bmal1a | Ensembl, NCBI gene |
| cel.2 | carboxyl ester lipase, tandem duplicate 2 | Oryzias latipes | 12 | NC_136248.1 (3762657..3755622) | cel.2 | Ensembl, NCBI gene |
| bsal | Oryzias latipes | - | no genomic information (-..-) | bsal | Ensembl |
Contact us
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Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2026). OMIA:003066-8090: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2026 | Hata, T., Tsuda, K., Hirayoshi, M., Miyanishi, H., Hikima, J.I., Kono, T. : |
| Expression dynamics of immune-related genes in circadian regulator Bmal1-deficient medaka (Oryzias latipes). Fish Shellfish Immunol 176:S1050-4648(26)00320-7:111416, 2026. Pubmed reference: 42162880. DOI: 10.1016/j.fsi.2026.111416. | |
| Liang, J., Li, J., Huang, Y., Zhou, M., Wang, R., Cao, X., Li, H., Chen, T. : | |
| nphp4 deficiency disrupts testicular homeostasis and impairs male fertility in medaka (Oryzias latipes). Reproduction 171:xaag027, 2026. Pubmed reference: 41782365. DOI: 10.1093/reprod/xaag027. | |
| Rusni, S., Yoshioka, Y., Pratiwi, H.M., Takagi, T., Royan, M.R., Hojo, Y., Uno, S., Kanda, S., Takehana, Y., Kinoshita, M., Inoue, K. : | |
| Cytochrome P450 1a (CYP1A)-knockout Javanese medaka fish exhibit diabetic traits and reduced reproductive capacity. FASEB J 40:e71935, 2026. Pubmed reference: 42333022. DOI: 10.1096/fj.202502623R. | |
| Sakai-Yamada, Y., Myosho, T., Kobayashi, T. : | |
| Effects of cyp19a1a and cyp19a1b knockout on germ cell kinetics during gonadal sex differentiation in medaka. Dev Growth Differ 68:e70038, 2026. Pubmed reference: 41518061. DOI: 10.1111/dgd.70038. | |
| Xie, R., Zhu, C., Liang, X., Lu, K., Wu, J. : | |
| Knockout of bsal/cel.2 results in growth retardation, reduced lipid digestion and altered energy metabolism in medaka larvae (oryzias latipes). Funct Integr Genomics 26:100, 2026. Pubmed reference: 42128971. DOI: 10.1007/s10142-026-01867-3. |
Edit History
- Created by Imke Tammen on 25 Jul 2026
- Changed by Imke Tammen on 25 Jul 2026