OMIA:000033-9615 : Alzheimer disease, generic in Canis lupus familiaris

In other species: crab-eating macaque , domestic cat , saddleback dolphin , long-finned pilot whale , striped dolphin , Cuvier's beaked whale , pig , sheep , degu , white-beaked dolphin , Blainville's beaked whale , Indo-pacific bottlenose dolphin , Atlantic spotted dolphin

Categories: Nervous system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104310 (trait) , 502500 (trait) , 607822 (trait) , 606889 (trait)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: yes

Species-specific name: Canine cognitive dysfunction, CCD


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 Dewey, C.W., Rishniw, M., Sakovitch, K., Hollenbeck, J. :
Oral administration of an integrative supplement (CogniCaps<sup>®</sup>) improves cognitive scores in aging dogs with canine cognitive dysfunction for at least two months: An open-label investigation in 10 dogs. Open Vet J 13:188-192, 2023. Pubmed reference: 37073246 . DOI: 10.5455/OVJ.2023.v13.i2.6.
Mondino, A., Catanzariti, M., Mateos, D.M., Khan, M., Ludwig, C., Kis, A., Gruen, M.E., Olby, N.J. :
Sleep and cognition in aging dogs. A polysomnographic study. Front Vet Sci 10:1151266, 2023. Pubmed reference: 37187924 . DOI: 10.3389/fvets.2023.1151266.
2020 Story, B.D., Miller, M.E., Bradbury, A.M., Million, E.D., Duan, D., Taghian, T., Faissler, D., Fernau, D., Beecy, S.J., Gray-Edwards, H.L. :
Canine models of inherited musculoskeletal and neurodegenerative diseases. Front Vet Sci 7:80, 2020. Pubmed reference: 32219101 . DOI: 10.3389/fvets.2020.00080.
2012 Bosch, M.N., Pugliese, M., Gimeno-Bayón, J., Rodríguez, M.J., Mahy, N. :
Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's disease. Curr Alzheimer Res 9:298-314, 2012. Pubmed reference: 21875411 .
2011 González-Martínez, Á., Rosado, B., Pesini, P., Suárez, M.L., Santamarina, G., García-Belenguer, S., Villegas, A., Monleón, I., Sarasa, M. :
Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. Exp Gerontol 46:590-6, 2011. Pubmed reference: 21377518 . DOI: 10.1016/j.exger.2011.02.013.
2009 Sarasa, M., Pesini, P. :
Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res 6:171-8, 2009. Pubmed reference: 19355852 .
2008 Cotman, CW., Head, E. :
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis 15:685-707, 2008. Pubmed reference: 19096165 .
2006 Rofina, JE., van Ederen, AM., Toussaint, MJ., Secreve, M., van der Spek, A., van der Meer, I., Van Eerdenburg, FJ., Gruys, E. :
Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res 1069:216-26, 2006. Pubmed reference: 16423332 . DOI: 10.1016/j.brainres.2005.11.021.
2003 Rofina, J., van Andel, I., van Ederen, AM., Papaioannou, N., Yamaguchi, H., Gruys, E. :
Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 10:86-96, 2003. Pubmed reference: 12964416 .
2001 Head, E. :
Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther 2:247-60, 2001. Pubmed reference: 19746668 .
1997 Lim, G.P., Russell, M.J., Cullen, M.J., Tokes, Z.A. :
Matrix metalloproteinases in dog brains exhibiting alzheimer-like characteristics Journal of Neurochemistry 68:1606-1611, 1997. Pubmed reference: 9084432 .
1993 Cummings, B.J., Su, J.H., Cotman, C.W., White, R., Russell, M.J. :
beta-Amyloid Accumulation in Aged Canine Brain - A Model of Early Plaque Formation in Alzheimers Disease Neurobiology of Aging 14:547-560, 1993. Pubmed reference: 8295657 .

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 21 Apr 2023