OMIA:000033-9615 : Alzheimer-like disease, generic in Canis lupus familiaris (dog)

In other species: crab-eating macaque , Rhesus monkey , domestic cat , saddleback dolphin , long-finned pilot whale , striped dolphin , Cuvier's beaked whale , pig , sheep , degu , white-beaked dolphin , Blainville's beaked whale , green monkey , Indo-pacific bottlenose dolphin , Atlantic spotted dolphin , Chinese tree shrew , black-striped capuchin

Categories: Nervous system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 104300 (trait) , 104310 (trait) , 502500 (trait) , 607822 (trait) , 606889 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: renamed from Alzheimer disease, generic to Alzheimer-like disease, generic [20/07/2023].

Species-specific name: Canine cognitive dysfunction, CCD

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000033-9615: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2023 de Sousa, A.A., Rigby Dames, B.A., Graff, E.C., Mohamedelhassan, R., Vassilopoulos, T., Charvet, C.J. :
Going beyond established model systems of Alzheimer's disease: companion animals provide novel insights into the neurobiology of aging. Commun Biol 6:655, 2023. Pubmed reference: 37344566. DOI: 10.1038/s42003-023-05034-3.
Dewey, C.W., Rishniw, M., Sakovitch, K., Hollenbeck, J. :
Oral administration of an integrative supplement (CogniCaps<sup>®</sup>) improves cognitive scores in aging dogs with canine cognitive dysfunction for at least two months: An open-label investigation in 10 dogs. Open Vet J 13:188-192, 2023. Pubmed reference: 37073246. DOI: 10.5455/OVJ.2023.v13.i2.6.
Ehrenzweig, J., Hunter, R.P. :
Canine cognitive decline and Alzheimer disease: clinical insights to solve a shared one-health problem. J Am Vet Med Assoc :1-8, 2023. Pubmed reference: 37758186. DOI: 10.2460/javma.23.02.0095.
Hines, A.D., McGrath, S., Latham, A.S., Kusick, B., Mulligan, L., Richards, M.L., Moreno, J.A. :
Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline. Front Aging Neurosci 15:1128521, 2023. Pubmed reference: 37304080. DOI: 10.3389/fnagi.2023.1128521.
Hunter, R.P., Ehrenzweig, J., Hainsworth, A., Crawford, A., Dagan, A., Sage, J., Araujo, J. :
One-health approach to canine cognitive decline: Dogs Overcoming Geriatric Memory and Aging Initiative for early detection of cognitive decline. Am J Vet Res :1-5, 2023. Pubmed reference: 37739391. DOI: 10.2460/ajvr.23.02.0032.
Kutzsche, J., Schemmert, S., Bujnicki, T., Zafiu, C., Halbgebauer, S., Kraemer-Schulien, V., Pils, M., Blömeke, L., Post, J., Kulawik, A., Jürgens, D., Rossberg, W.M., Hümpel, M., Bannach, O., Otto, M., Araujo, J.A., Willuweit, A., Willbold, D. :
Oral treatment with the all-d-peptide RD2 enhances cognition in aged beagle dogs - A model of sporadic Alzheimer's disease. Heliyon 9:e18443, 2023. Pubmed reference: 37609390. DOI: 10.1016/j.heliyon.2023.e18443.
Mondino, A., Khan, M., Case, B., Fefer, G., Panek, W.K., Gruen, M.E., Olby, N.J. :
Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs. Front Vet Sci 10:1150590, 2023. Pubmed reference: 37396989. DOI: 10.3389/fvets.2023.1150590.
Mondino, A., Catanzariti, M., Mateos, D.M., Khan, M., Ludwig, C., Kis, A., Gruen, M.E., Olby, N.J. :
Sleep and cognition in aging dogs. A polysomnographic study. Front Vet Sci 10:1151266, 2023. Pubmed reference: 37187924. DOI: 10.3389/fvets.2023.1151266.
Prévot, V., Duittoz, A. :
A role for GnRH in olfaction and cognition: Implications for veterinary medicine. Reprod Domest Anim 58 Suppl 2:109-124, 2023. Pubmed reference: 37329313. DOI: 10.1111/rda.14411.
Templeton, G.B., Fefer, G., Case, B.C., Roach, J., Azcarate-Peril, M.A., Gruen, M.E., Callahan, B.J., Olby, N.J. :
Longitudinal analysis of canine oral microbiome using whole genome sequencing in aging companion dogs. Animals (Basel) 13:3846, 2023. Pubmed reference: 38136883. DOI: 10.3390/ani13243846.
Turcsán, B., Kubinyi, E. :
Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs. Geroscience , 2023. Pubmed reference: 37740140. DOI: 10.1007/s11357-023-00945-9.
Wrightson, R., Albertini, M., Pirrone, F., McPeake, K., Piotti, P. :
The relationship between signs of medical conditions and cognitive decline in senior dogs. Animals (Basel) 13:2203, 2023. Pubmed reference: 37443999. DOI: 10.3390/ani13132203.
Wu, C.H., Pan, X.S., Su, L.Y., Yang, S.Y. :
Plasma neurofilament light chains as blood-based biomarkers for early diagnosis of canine cognitive dysfunction syndrome. Int J Mol Sci 24, 2023. Pubmed reference: 37762074. DOI: 10.3390/ijms241813771.
2020 Story, B.D., Miller, M.E., Bradbury, A.M., Million, E.D., Duan, D., Taghian, T., Faissler, D., Fernau, D., Beecy, S.J., Gray-Edwards, H.L. :
Canine models of inherited musculoskeletal and neurodegenerative diseases. Front Vet Sci 7:80, 2020. Pubmed reference: 32219101. DOI: 10.3389/fvets.2020.00080.
2012 Bosch, M.N., Pugliese, M., Gimeno-Bayón, J., Rodríguez, M.J., Mahy, N. :
Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's disease. Curr Alzheimer Res 9:298-314, 2012. Pubmed reference: 21875411.
2011 González-Martínez, Á., Rosado, B., Pesini, P., Suárez, M.L., Santamarina, G., García-Belenguer, S., Villegas, A., Monleón, I., Sarasa, M. :
Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. Exp Gerontol 46:590-6, 2011. Pubmed reference: 21377518. DOI: 10.1016/j.exger.2011.02.013.
2009 Sarasa, M., Pesini, P. :
Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res 6:171-8, 2009. Pubmed reference: 19355852.
2008 Cotman, CW., Head, E. :
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis 15:685-707, 2008. Pubmed reference: 19096165.
2006 Rofina, JE., van Ederen, AM., Toussaint, MJ., Secreve, M., van der Spek, A., van der Meer, I., Van Eerdenburg, FJ., Gruys, E. :
Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res 1069:216-26, 2006. Pubmed reference: 16423332. DOI: 10.1016/j.brainres.2005.11.021.
2003 Rofina, J., van Andel, I., van Ederen, AM., Papaioannou, N., Yamaguchi, H., Gruys, E. :
Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 10:86-96, 2003. Pubmed reference: 12964416.
2001 Head, E. :
Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther 2:247-60, 2001. Pubmed reference: 19746668.
1997 Lim, G.P., Russell, M.J., Cullen, M.J., Tokes, Z.A. :
Matrix metalloproteinases in dog brains exhibiting alzheimer-like characteristics Journal of Neurochemistry 68:1606-1611, 1997. Pubmed reference: 9084432.
1993 Cummings, B.J., Su, J.H., Cotman, C.W., White, R., Russell, M.J. :
beta-amyloid accumulation in aged canine brain - A model of early plaque formation in Alzheimers disease. Neurobiology of Aging 14:547-560, 1993. Pubmed reference: 8295657.

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Imke Tammen2 on 21 Apr 2023