OMIA 000033-9615 : Alzheimer disease, generic in Canis lupus familiaris

In other species: crab-eating macaque , domestic cat , pig , degu

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 104300 (trait) , 104310 (trait) , 502500 (trait) , 607822 (trait) , 606889 (trait)

Mendelian trait/disorder: unknown

Considered a defect: yes


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Story, B.D., Miller, M.E., Bradbury, A.M., Million, E.D., Duan, D., Taghian, T., Faissler, D., Fernau, D., Beecy, S.J., Gray-Edwards, H.L. :
Canine models of inherited musculoskeletal and neurodegenerative diseases. Front Vet Sci 7:80, 2020. Pubmed reference: 32219101. DOI: 10.3389/fvets.2020.00080.
2012 Bosch, M.N., Pugliese, M., Gimeno-Bayón, J., Rodríguez, M.J., Mahy, N. :
Dogs with cognitive dysfunction syndrome: a natural model of Alzheimer's disease. Curr Alzheimer Res 9:298-314, 2012. Pubmed reference: 21875411.
2011 González-Martínez, Á., Rosado, B., Pesini, P., Suárez, M.L., Santamarina, G., García-Belenguer, S., Villegas, A., Monleón, I., Sarasa, M. :
Plasma β-amyloid peptides in canine aging and cognitive dysfunction as a model of Alzheimer's disease. Exp Gerontol 46:590-6, 2011. Pubmed reference: 21377518. DOI: 10.1016/j.exger.2011.02.013.
2009 Sarasa, M., Pesini, P. :
Natural non-trasgenic animal models for research in Alzheimer's disease. Curr Alzheimer Res 6:171-8, 2009. Pubmed reference: 19355852.
2008 Cotman, CW., Head, E. :
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis 15:685-707, 2008. Pubmed reference: 19096165.
2006 Rofina, JE., van Ederen, AM., Toussaint, MJ., Secreve, M., van der Spek, A., van der Meer, I., Van Eerdenburg, FJ., Gruys, E. :
Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer's disease. Brain Res 1069:216-26, 2006. Pubmed reference: 16423332. DOI: 10.1016/j.brainres.2005.11.021.
2003 Rofina, J., van Andel, I., van Ederen, AM., Papaioannou, N., Yamaguchi, H., Gruys, E. :
Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 10:86-96, 2003. Pubmed reference: 12964416.
2001 Head, E. :
Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Vet Ther 2:247-60, 2001. Pubmed reference: 19746668.
1997 Lim, G.P., Russell, M.J., Cullen, M.J., Tokes, Z.A. :
Matrix metalloproteinases in dog brains exhibiting alzheimer-like characteristics Journal of Neurochemistry 68:1606-1611, 1997. Pubmed reference: 9084432.
1993 Cummings, B.J., Su, J.H., Cotman, C.W., White, R., Russell, M.J. :
beta-Amyloid Accumulation in Aged Canine Brain - A Model of Early Plaque Formation in Alzheimers Disease Neurobiology of Aging 14:547-560, 1993. Pubmed reference: 8295657.

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  • Created by Frank Nicholas on 06 Sep 2005