OMIA 000439-10036 : Hair, long in Mesocricetus auratus

In other species: domestic cat , goat , dog , rabbit , cattle , ass , domestic guinea pig , llama , Arabian camel , sheep , alpaca , domestic yak

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 190330 (trait) , 165190 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2014

Cross-species summary: Long hair = angora

Inheritance: Autosomal recessive (Fukuta et al., 1993)

Molecular basis: Yoshizawa et al. (2016) "detected a c.546delG of Fgf5 . . . that might lead to truncation resulting from a frame shift in FGF5 (p.Arg184GlyfsX6). Additionally, [homozygosity for this variant] . . . was only detected in long-haired . . . progenies, and all homozygous wild and heterozygous . . . individuals showed normal hair length. . . . To our knowledge, this report is the first to present the sexual dimorphism of hair length caused by the Fgf5 mutation."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
Fgf5 fibroblast growth factor 5 Mesocricetus auratus NW_024429190.1 (72569391..72591933) Fgf5 Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Inferred EVA rsID Year Published PubMed ID(s) Acknowledgements
559 Hair, long Fgf5 deletion, small (<=20) Naturally occurring variant c.546delG p.(R184GfsX6) 2015 26481120

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Yoshizawa, Y., Wada, K., Shimoi, G., Kameyama, Y., Wakabayashi, Y., Fukuta, K., Hashizume, R. :
Erratum to: A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mamm Genome 27:98, 2016. Pubmed reference: 26689206. DOI: 10.1007/s00335-015-9617-4.
2015 Yoshizawa, Y., Wada, K., Shimoi, G., Shiomi, G., Kameyama, Y., Wakabayashi, Y., Fukuta, K., Hashizume, R. :
A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mamm Genome 26:630-7, 2015. Pubmed reference: 26481120. DOI: 10.1007/s00335-015-9608-5.
1999 Mezick, J.A., Gendimenico, G.J., Liebel, F.T., Stenn, K.S. :
Androgen-induced delay of hair growth in the golden Syrian hamster. Br J Dermatol 140:1100-4, 1999. Pubmed reference: 10354077.
1993 Fukuta, K., Sakamoto, K., Hashizume, R., Mannen, H., Goto, N. :
Establishment of Inbred Strain of Long-Haired Golden Hamster Experimental Animals 42:343-347, 1993. Pubmed reference: 8354355.
1978 Robinson, R., Peterson, J.S., Yoon, C.H. :
Linkage group III in the Syrian hamster: linkage between white band and long hair. J Hered 69:199, 1978. Pubmed reference: 731009.
1975 Robinson, R. :
Linkage of white band and long hair in the Syrian hamster. J Hered 66:312, 1975. Pubmed reference: 1184955.
1973 Schimke, D.J., Nixon, C.W., Connelly, M.E. :
Long hair : A new mutation in the Syrian hamster Journal of Heredity 64:236-237, 1973. Pubmed reference: 4766213.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 15 Sep 2016