OMIA 000439-10036 : Hair, long in Mesocricetus auratus

In other species: domestic cat , goat , dog , rabbit , cattle , ass , domestic guinea pig , llama

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Key variant known: yes

Year key variant first reported: 2014

Cross-species summary: Long hair = angora

Inheritance: Autosomal recessive (Fukuta et al., 1993)

Molecular basis: Yoshizawa et al. (2016) "detected a c.546delG of Fgf5 . . . that might lead to truncation resulting from a frame shift in FGF5 (p.Arg184GlyfsX6). Additionally, [homozygosity for this variant] . . . was only detected in long-haired . . . progenies, and all homozygous wild and heterozygous . . . individuals showed normal hair length. . . . To our knowledge, this report is the first to present the sexual dimorphism of hair length caused by the Fgf5 mutation."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
Fgf5 fibroblast growth factor 5 Mesocricetus auratus - no genomic information (-..-) Fgf5 Homologene, Ensembl, NCBI gene

Variants

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Hair, long Fgf5 deletion, small (<=20) c.546delG p.Arg184GlyfsX6 2015 26481120

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Yoshizawa, Y., Wada, K., Shimoi, G., Kameyama, Y., Wakabayashi, Y., Fukuta, K., Hashizume, R. :
Erratum to: A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mamm Genome 27:98, 2016. Pubmed reference: 26689206. DOI: 10.1007/s00335-015-9617-4.
2015 Yoshizawa, Y., Wada, K., Shimoi, G., Shiomi, G., Kameyama, Y., Wakabayashi, Y., Fukuta, K., Hashizume, R. :
A 1-bp deletion in Fgf5 causes male-dominant long hair in the Syrian hamster. Mamm Genome 26:630-7, 2015. Pubmed reference: 26481120. DOI: 10.1007/s00335-015-9608-5.
1999 Mezick, J.A., Gendimenico, G.J., Liebel, F.T., Stenn, K.S. :
Androgen-induced delay of hair growth in the golden Syrian hamster. Br J Dermatol 140:1100-4, 1999. Pubmed reference: 10354077.
1993 Fukuta, K., Sakamoto, K., Hashizume, R., Mannen, H., Goto, N. :
Establishment of Inbred Strain of Long-Haired Golden Hamster Experimental Animals 42:343-347, 1993. Pubmed reference: 8354355.
1978 Robinson, R., Peterson, J.S., Yoon, C.H. :
Linkage group III in the Syrian hamster: linkage between white band and long hair. J Hered 69:199, 1978. Pubmed reference: 731009.
1975 Robinson, R. :
Linkage of white band and long hair in the Syrian hamster. J Hered 66:312, 1975. Pubmed reference: 1184955.
1973 Schimke, D.J., Nixon, C.W., Connelly, M.E. :
Long hair : A new mutation in the Syrian hamster Journal of Heredity 64:236-237, 1973. Pubmed reference: 4766213.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 15 Sep 2016