OMIA 000439-9925 : Hair, long in Capra hircus |
In other species:
domestic cat
,
golden hamster
,
dog
,
rabbit
,
cattle
,
ass
,
domestic guinea pig
,
llama
Mendelian trait/disorder:
unknown
Considered a defect:
no
Cross-species summary:
Long hair = angora
Species-specific description:
The molecular evidence reported in this entry is a result of the use of the CRISPR/Cas9 strategy to create genetically-modified (GMO) animals.
Molecular basis:
Wang et al. (2016) reported that "the disruption of FGF5 [by CRISPR/Cas9] results in increased number of second hair follicles and enhanced fiber length in Cas9-mediated goats, suggesting more cashmere will be produced"
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| FGF5 | fibroblast growth factor 5 | Capra hircus | - | no genomic information (-..-) | FGF5 | Homologene, Ensembl, NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2019 | Li, G., Zhou, S., Li, C., Cai, B., Yu, H., Ma, B., Huang, Y., Ding, Y., Liu, Y., Ding, Q., He, C., Zhou, J., Wang, Y., Zhou, G., Li, Y., Yan, Y., Hua, J., Petersen, B., Jiang, Y., Sonstegard, T., Huang, X., Chen, Y., Wang, X. : | |
| Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair. FEBS J :, 2019. Pubmed reference: 31276295. DOI: 10.1111/febs.14983. | ||
| 2016 | Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. : | |
| Correction: Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers. PLoS One 11:e0167322, 2016. Pubmed reference: 27875586. DOI: 10.1371/journal.pone.0167322. | ||
| Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. : | ||
| Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers. PLoS One 11:e0164640, 2016. Pubmed reference: 27755602. DOI: 10.1371/journal.pone.0164640. | ||
| 1987 | Lauvergne, J.J., Renieri, C., Audiot, A. : | |
| Estimating erosion of phenotypic variation in a French goat population Journal of Heredity 78:307-314, 1987. Pubmed reference: 3680926. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 25 Oct 2016