You are here: OMIA / Search / OMIA 000439 / goat

OMIA 000439-9925 : Hair, long in Capra hircus

In other species: domestic cat , golden hamster , dog , rabbit , cattle , ass , domestic guinea pig , llama

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 190330 (trait) , 165190 (gene)

Mendelian trait/disorder: unknown

Considered a defect: no

Cross-species summary: Long hair = angora

Species-specific description: The molecular evidence reported in this entry is a result of the use of the CRISPR/Cas9 strategy to create genetically-modified (GMO) animals.

Molecular basis: Wang et al. (2016) reported that "the disruption of FGF5 [by CRISPR/Cas9] results in increased number of second hair follicles and enhanced fiber length in Cas9-mediated goats, suggesting more cashmere will be produced"

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
FGF5 fibroblast growth factor 5 Capra hircus - no genomic information (-..-) FGF5 Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Li, G., Zhou, S., Li, C., Cai, B., Yu, H., Ma, B., Huang, Y., Ding, Y., Liu, Y., Ding, Q., He, C., Zhou, J., Wang, Y., Zhou, G., Li, Y., Yan, Y., Hua, J., Petersen, B., Jiang, Y., Sonstegard, T., Huang, X., Chen, Y., Wang, X. :
Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair. FEBS J :, 2019. Pubmed reference: 31276295. DOI: 10.1111/febs.14983.
2016 Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. :
Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers. PLoS One 11:e0164640, 2016. Pubmed reference: 27755602. DOI: 10.1371/journal.pone.0164640.
Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. :
Correction: Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers. PLoS One 11:e0167322, 2016. Pubmed reference: 27875586. DOI: 10.1371/journal.pone.0167322.
1987 Lauvergne, J.J., Renieri, C., Audiot, A. :
Estimating erosion of phenotypic variation in a French goat population Journal of Heredity 78:307-314, 1987. Pubmed reference: 3680926.

Edit History


  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 25 Oct 2016