OMIA:000439-9925 : Hair, long in Capra hircus |
In other species: domestic cat , golden hamster , dog , rabbit , cattle , ass , domestic guinea pig , llama , Arabian camel , sheep , alpaca , domestic yak
Categories: Integument (skin) phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 190330 (trait) , 165190 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: unknown
Considered a defect: no
Cross-species summary: Long hair = angora
Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).
Markers: Li et al. (2022) reported a naturally-occurring 507bp deletion roughly 14kb downstream of FGF5 that may be associated with fleece length in goats.
Molecular basis: Wang et al. (2016) reported that "the disruption of FGF5 [by CRISPR/Cas9] results in increased number of second hair follicles and enhanced fiber length in Cas9-mediated goats, suggesting more cashmere will be produced"
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| FGF5 | fibroblast growth factor 5 | Capra hircus | - | no genomic information (-..-) | FGF5 | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2023 | Song, T., Tan, Y., Cuomu, R., Liu, Y., Ba, G., Suo, L., Wu, Y., Cao, X., Zeng, X. : |
| Polymorphisms and mRNA expression levels of IGF-1, FGF5, and KAP 1.4 in Tibetan cashmere goats. Genes (Basel) 14:, 2023. Pubmed reference: 36980983 . DOI: 10.3390/genes14030711. | |
| 2022 | Li, Y., Song, S., Zhang, Z., Liu, X., Zhang, Y., E, G., Ma, Y., Jiang, L. : |
| A deletion variant within the FGF5 gene in goats is associated with gene expression levels and cashmere growth. Anim Genet 53:657-664, 2022. Pubmed reference: 35843706 . DOI: 10.1111/age.13239. | |
| 2019 | Li, G., Zhou, S., Li, C., Cai, B., Yu, H., Ma, B., Huang, Y., Ding, Y., Liu, Y., Ding, Q., He, C., Zhou, J., Wang, Y., Zhou, G., Li, Y., Yan, Y., Hua, J., Petersen, B., Jiang, Y., Sonstegard, T., Huang, X., Chen, Y., Wang, X. : |
| Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair. FEBS J :, 2019. Pubmed reference: 31276295 . DOI: 10.1111/febs.14983. | |
| 2016 | Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. : |
| Disruption of FGF5 in Cashmere goats using CRISPR/Cas9 results in more secondary hair follicles and longer fibers. PLoS One 11:e0164640, 2016. Pubmed reference: 27755602 . DOI: 10.1371/journal.pone.0164640. | |
| Wang, X., Cai, B., Zhou, J., Zhu, H., Niu, Y., Ma, B., Yu, H., Lei, A., Yan, H., Shen, Q., Shi, L., Zhao, X., Hua, J., Huang, X., Qu, L., Chen, Y. : | |
| Correction: Disruption of FGF5 in Cashmere goats using CRISPR/Cas9 results in more secondary hair follicles and longer fibers. PLoS One 11:e0167322, 2016. Pubmed reference: 27875586 . DOI: 10.1371/journal.pone.0167322. | |
| 2014 | He, X., Yuan, C., Chen, Y. : |
| Isolation, characterization, and expression analysis of FGF5 isoforms in cashmere goat. Small Ruminant Research 116:111-117, 2014. | |
| 1987 | Lauvergne, J.J., Renieri, C., Audiot, A. : |
| Estimating erosion of phenotypic variation in a French goat population Journal of Heredity 78:307-314, 1987. Pubmed reference: 3680926 . |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 25 Oct 2016
- Changed by Imke Tammen2 on 27 Aug 2021
- Changed by Frank Nicholas on 23 Aug 2022