OMIA 000439-9685 : Hair, long in Felis catus

In other species: dog , ass , llama , cattle , goat , rabbit , golden hamster , domestic guinea pig

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2007

Cross-species summary: Long hair = angora

Species-specific symbol: L

Inheritance: The dominant trait is short hair. Long hair is autosomal recessive.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
FGF5 fibroblast growth factor 5 Felis catus B1 NC_018726.3 (142186261..142163553) FGF5 Homologene, Ensembl, NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective.

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Maine Coon Persian Ragdoll Somali Long hair FGF5 missense c.194C>A p.P65H 2007 17433015
Long hair FGF5 insertion, small (<=20) c.ins356T 2007 17767004
Long hair FGF5 deletion, small (<=20) AM412646 c.474delT 2007 17433015
Long hair FGF5 missense Felis_catus_6.2 B1 g.140077554A>C c.475A>C p.T159P 2007 17433015 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool
Norwegian Forest Long hair FGF5 nonsense (stop-gain) Felis_catus_6.2 B1 g.140089230C>T c.406C>T p.R136* 2007 17767004 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool
Norwegian Forest Long hair FGF5 missense Felis_catus_6.2 B1 g.140097052T>A c.182T>A p.V61D 2007 17433015 Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2007 Drögemüller, C., Rüfenacht, S., Wichert, B., Leeb, T. :
Mutations within the FGF5 gene are associated with hair length in cats. Anim Genet 38:218-21, 2007. Pubmed reference: 17433015. DOI: 10.1111/j.1365-2052.2007.01590.x.
Kehler, J.S., David, V.A., Schäffer, A.A., Bajema, K., Eizirik, E., Ryugo, D.K., Hannah, S.S., O'Brien, S.J., Menotti-Raymond, M. :
Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats. J Hered 98:555-66, 2007. Pubmed reference: 17767004. DOI: 10.1093/jhered/esm072.
2000 Christensen, A.C. :
Cats as an aid to teaching genetics. Genetics 155:999-1004, 2000. Pubmed reference: 10880464.
Ruiz-Garcia, M. :
Is there really natural selection affecting the l frequencies (Long hair) in the Brazilian cat populations? Journal of Heredity 91:49-57, 2000. Pubmed reference: 10739126.
1990 Williams, J.A. :
Races of Short-Haired and Long-Haired Cats Tijdschrift Voor Diergeneeskunde 115:959, 1990.

Edit History


  • Created by Frank Nicholas on 26 Nov 2007
  • Changed by Frank Nicholas on 07 Oct 2011
  • Changed by Frank Nicholas on 09 Dec 2011
  • Changed by Frank Nicholas on 18 Jan 2015