In other species: domestic cat , goat , golden hamster , dog , rabbit , cattle , ass , domestic guinea pig , llama , Arabian camel , alpaca , domestic yak

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 190330 (trait) , 165190 (gene)

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Cross-species summary: Long hair = angora

Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO).

Hu et al. (2017): "generated 3 FGF5 knockout sheep via the 1-step clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system. Sequencing analysis confirmed that mutations in the FGF5 gene existed in all germ lines of 3 founders: besides the intact sequence, 3 kinds of deletions in the FGF5 gene (including 5, 13, and 33 bp) were detected. The changes in the primary and senior structure of the FGF5 protein due to the 3 deletions in founders suggested that the FGF5 protein was dysfunctional. In addition, the expression level of intact FGF5 mRNA in heterozygous individuals decreased compared with the wild types (P < 0.01). Functionally, we discovered that wool length in founders was significantly longer than in wild types (P < 0.05)."

Associated gene: