OMIA 000439-9940 : Hair, long in Ovis aries |
Hu et al. (2017): "generated 3 FGF5 knockout sheep via the 1-step clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system. Sequencing analysis confirmed that mutations in the FGF5 gene existed in all germ lines of 3 founders: besides the intact sequence, 3 kinds of deletions in the FGF5 gene (including 5, 13, and 33 bp) were detected. The changes in the primary and senior structure of the FGF5 protein due to the 3 deletions in founders suggested that the FGF5 protein was dysfunctional. In addition, the expression level of intact FGF5 mRNA in heterozygous individuals decreased compared with the wild types (P < 0.01). Functionally, we discovered that wool length in founders was significantly longer than in wild types (P < 0.05)."
Associated gene:Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
FGF5 | fibroblast growth factor 5 | Ovis aries | 6 | NC_056059.1 (95668983..95690859) | FGF5 | Homologene, Ensembl, NCBI gene |
Reference
2017 | Hu, R., Fan, Z.Y., Wang, B.Y., Deng, S.L., Zhang, X.S., Zhang, J.L., Han, H.B., Lian, Z.X. : | |
RAPID COMMUNICATION: Generation of FGF5 knockout sheep via the CRISPR/Cas9 system. J Anim Sci 95:2019-2024, 2017. Pubmed reference: 28727005. DOI: 10.2527/jas.2017.1503. |
Edit History
- Created by Imke Tammen2 on 27 Aug 2021
- Changed by Imke Tammen2 on 27 Aug 2021