OMIA:000439-9940 : Hair, long in Ovis aries (sheep) |
In other species: dog , domestic cat , ass (donkey) , Arabian camel , llama , taurine cattle , goat , rabbit , golden hamster , domestic guinea pig , domestic yak , alpaca
Categories: Integument (skin) phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 190330 (trait) , 165190 (gene)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Disease-related: no
Key variant known: no
Cross-species summary: Long hair = angora
Species-specific description: This phene includes references to studies involving genetically modified organisms (GMO). Hu et al. (2017): "generated 3 FGF5 knockout sheep via the 1-step clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system. Sequencing analysis confirmed that mutations in the FGF5 gene existed in all germ lines of 3 founders: besides the intact sequence, 3 kinds of deletions in the FGF5 gene (including 5, 13, and 33 bp) were detected. The changes in the primary and senior structure of the FGF5 protein due to the 3 deletions in founders suggested that the FGF5 protein was dysfunctional. In addition, the expression level of intact FGF5 mRNA in heterozygous individuals decreased compared with the wild types (P < 0.01). Functionally, we discovered that wool length in founders was significantly longer than in wild types (P < 0.05)." Zhang et al. (2020): "generated five FGF5-knockout Dorper sheep by the CRISPR/Cas9 system. The expression level of FGF5 mRNA in knockout (KO) sheep decreased significantly, and all FGF5 proteins were dysfunctional. The KO sheep displayed a significant increase in fine-wool and active hair-follicle density."
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| FGF5 | fibroblast growth factor 5 | Ovis aries | 6 | NC_056059.1 (95668983..95690859) | FGF5 | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000439-9940: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Chen, M., Li, Y., Xu, X., Wang, S., Liu, Z., Qi, S., Si, D., Man, Z., Deng, S., Liu, G., Zhao, Y., Yu, K., Lian, Z. : |
| Metabolic differences in MSTN and FGF5 dual-gene edited sheep muscle cells during myogenesis. BMC Genomics 25:637, 2024. Pubmed reference: 38926663. DOI: 10.1186/s12864-024-10494-w. | |
| Chen, M.M., Zhao, Y., Yu, K., Xu, X.L., Zhang, X.S., Zhang, J.L., Wu, S.J., Liu, Z.M., Yuan, Y.M., Guo, X.F., Qi, S.Y., Yi, G., Wang, S.Q., Li, H.X., Wu, A.W., Liu, G.S., Deng, S.L., Han, H.B., Lv, F.H., Lian, D., Lian, Z.X. : | |
| A MSTN Del73C mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia. Elife 12:RP86827, 2024. Pubmed reference: 39365728. DOI: 10.7554/eLife.86827. | |
| Niu, Y., Li, Y., Zhao, Y., He, X., Zhao, Q., Pu, Y., Ma, Y., Jiang, L. : | |
| Whole-genome sequencing identifies functional genes for environmental adaptation in Chinese sheep. J Genet Genomics , 2024. Pubmed reference: 39260683. DOI: 10.1016/j.jgg.2024.08.011. | |
| Sun, H., He, Z., Zhao, F., Hu, J., Wang, J., Liu, X., Zhao, Z., Li, M., Luo, Y., Li, S. : | |
| Molecular genetic characteristics of the Hoxc13 gene and association analysis of wool traits. Int J Mol Sci 25:1594, 2024. Pubmed reference: 38338874. DOI: 10.3390/ijms25031594. | |
| Xu, X.L., Wu, S.J., Qi, S.Y., Chen, M.M., Liu, Z.M., Zhang, R., Zhao, Y., Liu, S.Q., Zhou, W.D., Zhang, J.L., Zhang, X.S., Deng, S.L., Yu, K., Li, Y., Lian, Z.X. : | |
| Increasing GSH-Px activity and activating Wnt pathway promote fine wool growth in FGF5-edited sheep. Cells 13:985, 2024. Pubmed reference: 38891117. DOI: 10.3390/cells13110985. | |
| 2023 | Chen, M., Lian, D., Li, Y., Zhao, Y., Xu, X., Liu, Z., Zhang, J., Zhang, X., Wu, S., Qi, S., Deng, S., Yu, K., Lian, Z. : |
| Global long noncoding RNA expression profiling of MSTN and FGF5 double-knockout sheep reveals the key gatekeepers of skeletal muscle development. DNA Cell Biol 42:163-175, 2023. Pubmed reference: 36917699. DOI: 10.1089/dna.2022.0574. | |
| Chen, M., Zhao, Y., Li, Y., Chen, T., Zhou, W., Zhang, X., Deng, S., Xu, X., Wu, S., Liu, Z., Qi, S., Wang, L., Li, Y., Yu, K., Lian, Z. : | |
| Reproduction and viscera organ characteristics of MSTN and FGF5 dual-gene knockout sheep. Front Vet Sci 10:1119312, 2023. Pubmed reference: 37065235. DOI: 10.3389/fvets.2023.1119312. | |
| 2020 | Zhang, R., Li, Y., Jia, K., Xu, X., Li, Y., Zhao, Y., Zhang, X., Zhang, J., Liu, G., Deng, S., Lian, Z. : |
| Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep. Cell Death Dis 11:407, 2020. Pubmed reference: 32472005. DOI: 10.1038/s41419-020-2622-x. | |
| 2017 | Hu, R., Fan, Z.Y., Wang, B.Y., Deng, S.L., Zhang, X.S., Zhang, J.L., Han, H.B., Lian, Z.X. : |
| RAPID COMMUNICATION: Generation of FGF5 knockout sheep via the CRISPR/Cas9 system. J Anim Sci 95:2019-2024, 2017. Pubmed reference: 28727005. DOI: 10.2527/jas.2017.1503. |
Edit History
- Created by Imke Tammen2 on 27 Aug 2021
- Changed by Imke Tammen2 on 27 Aug 2021
- Changed by Imke Tammen2 on 15 Nov 2023
- Changed by Imke Tammen2 on 10 Dec 2023