OMIA:000683-8255 : Muscular hypertrophy (double muscling) in Paralichthys olivaceus (Japanese flounder) |
In other species: Mallard , rock pigeon , chicken , dog , pig , taurine cattle , goat , sheep , rabbit , pacu , water buffalo , Japanese quail , red seabream , yellow catfish
Categories: Muscle phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)
Links to relevant human diseases in MONDO:
Single-gene trait/disorder: yes
Disease-related: no
Key variant known: yes
Year key variant first reported: 2019
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description:
Kim et al. (2019) "introduced a CRISPR/Cas9 system to disrupt Paralichthys olivaceus MSTN (PoMSTN) using microinjection. ... PoMSTN-disrupted P. olivaceus exhibited greater body thickness and increased condition factor, indicating the enhancement of muscle mass with muscle hyperplasia."
Kim et al. (2024) "assessed the genome-wide transcriptional expression pattern associated with the CRISPR/Cas9-mutated MSTN gene in the olive flounder (Paralichthys olivaceus) in association with changes in cell proliferation and transportation processes. There were no differences in the hepatosomatic index, and the growth of male and female fish increased in the F1 progeny of the MSTN mutants."
This phene includes references to studies involving gene edited or genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
---|---|---|---|---|---|---|
MSTN | Paralichthys olivaceus | - | no genomic information (-..-) | MSTN | Ensembl |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000683-8255: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2024 | Kim, J.W., Kim, J., Cho, J.Y., Shin, Y., Son, H., Sathiyamoorthy, S., Kim, B.S., Kim, Y.O., Kang, B.C., Kong, H.J. : |
Association between muscle growth and transcription of a mutant MSTN gene in olive flounder (Paralichthys olivaceus). Mar Biotechnol (NY) 26:599-608, 2024. Pubmed reference: 38683458. DOI: 10.1007/s10126-024-10322-y. | |
2019 | Kim J,, Cho, JY, Kim, J-W, Kim, H-C, Noh, JK, Kim, Y-O, Hwang, H-K, Kim, W-J, Yeo, S-Y, An, CM, Park, JY, Kong, HJ : |
CRISPR/Cas9-mediated myostatin disruption enhances muscle mass in the olive flounder Paralichthys olivaceus. Aquaculture 512:734336, 2019. |
Edit History
- Created by Imke Tammen2 on 01 May 2024
- Changed by Imke Tammen2 on 01 May 2024