OMIA:001089-9541 : Blood group system ABO in Macaca fascicularis (crab-eating macaque)

In other species: Japanese macaque , Rhesus monkey , olive baboon , agile gibbon , common gibbon , siamang , chimpanzee , pig

Categories: Haematopoietic system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 110300 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal co-dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 1998

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars. The ABO blood group system arises from two alleles at a locus that encodes a glycosyltransferase: the A allele encodes alpha 1-3-N-acetylgalactosaminyltransferase; and the B allele encodes alpha 1-3-galactosyltransferase. The B allele transferase catalyses the addition of galactose to a chain of four sugars attached to a protein known as H antigen. The A allele ltransferase catalyses the addition of a derivative of galactose called N-acetylgalactosamine to the same short chain of sugars. The third allele at this locus (the O allele) results in no sugar being added to the chain.

Molecular basis: Doxiadis et al. (1998) reported that the A and B alleles differ by just two missense mutations in codons 266 and 268. Thus allele A is a reflection of the peptide haplotype p.266Leu + p.268Gly, and allele B reflects the peptide haplotype p.266Met + p.268Ala.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) Macaca fascicularis 15 NC_052269.1 (104860645..104838443) ABO Homologene, Ensembl , NCBI gene


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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
20 A antigen ABO haplotype Naturally occurring variant p.266L + p.268G Allele A is reflected in the peptide haplotype p.266Leu + p.268Gly 1998 9583803
1175 B antigen ABO haplotype Naturally occurring variant p.266M + p.268A Allele B is a reflection of the peptide haplotype p.266Met + p.268Ala 1998 9583803

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2020). OMIA:001089-9541: Online Mendelian Inheritance in Animals (OMIA) [dataset].


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2019 Kanthaswamy, S., Oldt, R.F., Said, R., Grijalva, J., Falak, A., Jensen, A., Vizor, C., Houghton, P., Bunlungsup, S., Malaivijitnond, S., Smith, D.G. :
Partial Sequence Analyses of Exon 7 of the ABO Locus of Cynomolgus (Macaca fascicularis) and Rhesus (M. mulatta) Macaques: Indeterminate Phenotypes Reveal the Presence of the O Blood Group. HLA , 2019. Pubmed reference: 31448567. DOI: 10.1111/tan.13675.
2017 Wang, X., Chen, S., Chen, G. :
ABO typing in experimental cynomolgus monkeys using non-invasive methods. Sci Rep 7:41274, 2017. Pubmed reference: 28112245. DOI: 10.1038/srep41274.
2009 Chen, S., Wei, Q., Li, J., Xiang, Y., Guo, H., Ichim, T.E., Chen, S., Chen, G. :
A simple and reliable method to blood type monkeys using serum samples. Transpl Int 22:999-1004, 2009. Pubmed reference: 19298252. DOI: 10.1111/j.1432-2277.2009.00859.x.
2008 Malaivijitnond, S., Sae-Low, W., Hamada, Y. :
The human-ABO blood groups of free-ranging long-tailed macaques (Macaca fascicularis) and parapatric rhesus macaques (M. mulatta) in Thailand. J Med Primatol 37:31-7, 2008. Pubmed reference: 18199070. DOI: 10.1111/j.1600-0684.2007.00223.x.
1999 Kermarrec, N., Roubinet, F., Apoil, P.A., Blancher, A. :
Comparison of allele O sequences of the human and non-human primate ABO system. Immunogenetics 49:517-26, 1999. Pubmed reference: 10380696.
1998 Doxiadis, G.G., Otting, N., Antunes, S.G., de Groot, N.G., Harvey, M., Doxiadis, I.I., Jonker, M., Bontrop, R.E. :
Characterization of the ABO blood group genes in macaques: evidence for convergent evolution. Tissue Antigens 51:321-6, 1998. Pubmed reference: 9583803.
1981 Terao, K., Fujimoto, K., Cho, F., Honjo, S. :
Inheritance and distribution of human-type A-B-O blood groups in cynomolgus monkeys. J Med Primatol 10:72-80U, 1981. Pubmed reference: 7338891. DOI: 10.1159/000460057.
1974 Wiener, A.S., Socha, W.W., Moor-Jankowski, J. :
Homologous of the human A-B-O blood groups in apes and monkeys. Haematologia (Budap) 8:195-216, 1974. Pubmed reference: 4142617.
1968 Moor-Jankowski, J., Wiener, A.S. :
Blood groups of non-human primates. Summary of the currently available information. Primates Med 1:49-67, 1968. Pubmed reference: 4135382.

Edit History

  • Created by Frank Nicholas on 19 Oct 2011
  • Changed by Frank Nicholas on 12 Dec 2011
  • Changed by Frank Nicholas on 21 Mar 2012
  • Changed by Frank Nicholas on 31 Mar 2020