OMIA:001089-9823 : Blood group system ABO in Sus scrofa (pig)

In other species: crab-eating macaque , Japanese macaque , Rhesus monkey , olive baboon , agile gibbon , common gibbon , siamang , chimpanzee

Categories: Haematopoietic system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 110300 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2001

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars. The ABO blood group system arises from two alleles at a locus that encodes a glycosyltransferase: the A allele encodes alpha 1-3-N-acetylgalactosaminyltransferase; and the B allele encodes alpha 1-3-galactosyltransferase. The B allele transferase catalyses the addition of galactose to a chain of four sugars attached to a protein known as H antigen. The A allele ltransferase catalyses the addition of a derivative of galactose called N-acetylgalactosamine to the same short chain of sugars. The third allele at this locus (the O allele) results in no sugar being added to the chain.

Species-specific description: Pigs have just two alleles at this locus, namely A and O (Yamamoto and Yamamoto, 2001). The A antigen is known as the major xenotransplantation antigen or major xenoantigen. Galactose-alpha-1,3-galactose is the cause of rare allergic reaction to red meat consumption. Variants of this trait have been created artificially: Genetically-modifed organism; GMO.

History: Sprague (1958) was among the first to suggest that pigs may have an ABO-like blood group system (on the basis of the reaction of pig red blood cells to typing sera from cattle). His observations were confirmed by Andresen (1962) and Saison and Imgram (1962).

Molecular basis: By cloning and sequencing a very likely comparative candidate gene (based on the homologous human disorder), Yamamoto and Yamamoto (2001) showed that the A allele corresponds to a functional GGTA1 gene, whereas the O allele includes a major deletion of this gene. Nguyen et al. (2011) provided more detail on this deletion: "the 0 allele has a large deletion between exon 7 of the A0 blood group gene and the neighbouring SURF6". Using transcription activator-like effector nucleases (TALENs) to generate GGTA1 knockout fibroblast cell lines, which were then used in somatic cell nuclear transfer, Xin et al. (2013) generated pigs with no effective GGTA1 genes, which "can provide a new organ source for xenotransplantation research". Kan et al. (2016) achieved a similar result with the same technology; Petersen et al. (2016) achieved a similar results with CRISPR/Cas9 technology.

Genetic engineering: Yes - in addition to the occurrence of natural variants, variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Clinical features: The clinical importance of porcine AO antigens relates to the use of pig tissue and organs in transplantation to humans (xenotransplantation): the major cell-surface antigen causing rejection in porcine-human xenotransplantation is the A antigen produced by the enzyme encoded by this locus, i.e. by the enzyme alpha1-3 N-acetyl-D-galactosaminyltransferase (known as "gal transferase [GT]"), encoded by GGTA1. Consequently, as soon as gene knockout and animal cloning technology became available (i.e. in vitro gene knockout, followed by somatic cell nuclear transfer to produce cloned animals), clones of gal-transferase knockout (GTKO) pigs were produced for use as donors in xenotransplantation. The first GTKO pigs were produced by Lai et al. (2002). Furthermore, galactose-alpha-1,3-galactose ("alpha-gal") on the muscle cell surface in pigs, sheep and cattle may induce allergies (alpha-gal syndrome) in humans consuming red meat (Commins et al., 2016). GGTA1 knock out pigs have been approved by the FDA as GalSafe pigs for pork consumption (https://www.fda.gov/news-events/press-announcements/fda-approves-first-its-kind-intentional-genomic-alteration-line-domestic-pigs-both-human-food).

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
GGTA1 glycoprotein, alpha-galactosyltransferase 1 Sus scrofa 1 NC_010443.5 (261587968..261511304) GGTA1 Homologene, Ensembl , NCBI gene

Variants

By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.

OMIA Variant ID Breed(s) Variant Phenotype Gene Allele Type of Variant Source of Genetic Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
655 Blood group system ABO GGTA1 O deletion, gross (>20) Naturally occurring variant 1 "the 0 allele has a large deletion between exon 7 of the A0 blood group gene and the neighbouring SURF6". 2011 21554350

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001089-9823: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 King, N.C., Tsui, J.M., Bejar-Chapa, M., Marshall, M.S., Kogosov, A.S., Fan, Y., Hansdorfer, M.A., Locascio, J.J., Randolph, M.A., Winograd, J.M. :
Gal - T knockout porcine nerve xenografts support axonal regeneration in a rodent sciatic nerve model. Plast Reconstr Surg , 2024. Pubmed reference: 38548707. DOI: 10.1097/PRS.0000000000011441.
Raza, S.S., Hara, H., Eyestone, W., Ayares, D., Cleveland, D.C., Cooper, D.K.C. :
Pigs in Transplantation Research and Their Potential as Sources of Organs in Clinical Xenotransplantation. Comp Med , 2024. Pubmed reference: 38359908. DOI: 10.30802/AALAS-CM-23-000030.
Wang, Y., Hils, M., Fischer, A., Wölbing, F., Biedermann, T., Schnieke, A., Fischer, K. :
Gene-edited pigs: a translational model for human food allergy against alpha-Gal and anaphylaxis. Front Immunol 15:1358178, 2024. Pubmed reference: 38469303. DOI: 10.3389/fimmu.2024.1358178.
Yuan, Y., Cui, Y., Zhao, D., Yuan, Y., Zhao, Y., Li, D., Jiang, X., Zhao, G. :
Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage. J Transl Med 22:324, 2024. Pubmed reference: 38566098. DOI: 10.1186/s12967-024-05136-4.
Zhang, B., Ji, P., Peng, L., Zhai, M., Tang, J., Zhao, L., Jin, Y., Xu, B., Lyu, X., Lu, L., Zhou, Y., Jin, Z., Duan, W., Yang, X., Yi, W., Liu, J. :
Clinical treatment procedure and experience of six gene-edited pig-rhesus monkey heterotopic heart xenotransplantation. Chin Med J (Engl) , 2024. Pubmed reference: 38432900. DOI: 10.1097/CM9.0000000000003030.
2023 Bolner, M., Bertolini, F., Bovo, S., Schiavo, G., Fontanesi, L. :
Investigation of ABO gene variants across more than 60 pig breeds and populations and other Suidae species using whole-genome sequencing datasets. Animals (Basel) 14:5, 2023. Pubmed reference: 38200737. DOI: 10.3390/ani14010005.
Cooper, D.K.C., Pierson, R.N. :
Milestones on the path to clinical pig organ xenotransplantation. Am J Transplant 23:326-335, 2023. Pubmed reference: 36775767. DOI: 10.1016/j.ajt.2022.12.023.
Morticelli, L., Rossdam, C., Cajic, S., Böthig, D., Magdei, M., Tuladhar, S.R., Petersen, B., Fischer, K., Rapp, E., Korossis, S., Haverich, A., Schnieke, A., Niemann, H., Buettner, F.F.R., Hilfiker, A. :
Genetic knockout of porcine GGTA1 or CMAH/GGTA1 is associated with the emergence of neo-glycans. Xenotransplantation :e12804, 2023. Pubmed reference: 37148126. DOI: 10.1111/xen.12804.
Takebayashi, K., Wittayarat, M., Lin, Q., Torigoe, N., Liu, B., Hirata, M., Nagahara, M., Tanihara, F., Otoi, T. :
Efficiency of genetic modification in gene-knockout sperm-derived zygotes followed by electroporation of guide RNA targeting the same gene. Anim Sci J 94:e13842, 2023. Pubmed reference: 37218074. DOI: 10.1111/asj.13842.
2022 Anwar, I.J., DeLaura, I., Gao, Q., Knechtle, S., Kwun, J. :
Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life sustaining NHP renal allo- and xeno-transplants by Firl and Markmann. Am J Transplant 22:1933-1934, 2022. Pubmed reference: 35181999. DOI: 10.1111/ajt.17007.
Firl, D.J., Markmann, J.F. :
Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life-sustaining NHP renal allo- and xeno-transplants. Am J Transplant 22:1527-1536, 2022. Pubmed reference: 35143091. DOI: 10.1111/ajt.16994.
Firl, D.J., Markmann, J.F. :
Reply to "Letter to the editor in response to: Measuring success in pig to non-human-primate renal xenotransplantation: Systematic review and comparative outcomes analysis of 1051 life-sustaining NHP renal allo- and xeno-transplants". Am J Transplant 22:2279-2280, 2022. Pubmed reference: 35278274. DOI: 10.1111/ajt.17029.
Tu, C.F., Chuang, C.K., Yang, T.S. :
The application of new breeding technology based on gene editing in pig industry - A review. Anim Biosci 35:791-803, 2022. Pubmed reference: 34991204. DOI: 10.5713/ab.21.0390.
2021 Choe, H.M., Luo, Z.B., Kang, J.D., Oh, M.J., An, H.J., Yin, X.J. :
Pathological features in 'humanized' neonatal pig. Anim Biotechnol :1-9, 2021. Pubmed reference: 34392816. DOI: 10.1080/10495398.2021.1962896.
Yue, Y., Xu, W., Kan, Y., Zhao, H.Y., Zhou, Y., Song, X., Wu, J., Xiong, J., Goswami, D., Yang, M., Lamriben, L., Xu, M., Zhang, Q., Luo, Y., Guo, J., Mao, S., Jiao, D., Nguyen, T.D., Li, Z., Layer, J.V., Li, M., Paragas, V., Youd, M.E., Sun, Z., Ding, Y., Wang, W., Dou, H., Song, L., Wang, X., Le, L., Fang, X., George, H., Anand, R., Wang, S.Y., Westlin, W.F., Güell, M., Markmann, J., Qin, W., Gao, Y., Wei, H.J., Church, G.M., Yang, L. :
Extensive germline genome engineering in pigs. Nat Biomed Eng 5:134-143, 2021. Pubmed reference: 32958897. DOI: 10.1038/s41551-020-00613-9.
2020 Choi, K., Shim, J., Ko, N., Park, J. :
No excessive mutations in transcription activator-like effector nuclease-mediated α-1,3-galactosyltransferase knockout Yucatan miniature pigs. Asian-Australas J Anim Sci 33:360-372, 2020. Pubmed reference: 31480150. DOI: 10.5713/ajas.19.0480.
2017 Chuang, C.K., Chen, C.H., Huang, C.L., Su, Y.H., Peng, S.H., Lin, T.Y., Tai, H.C., Yang, T.S., Tu, C.F. :
Generation of GGTA1 mutant pigs by direct pronuclear microinjection of CRISPR/Cas9 plasmid vectors. Anim Biotechnol 28:174-181, 2017. Pubmed reference: 27834588. DOI: 10.1080/10495398.2016.1246453.
Gao, H., Zhao, C., Xiang, X., Li, Y., Zhao, Y., Li, Z., Pan, D., Dai, Y., Hara, H., Cooper, D.K., Cai, Z., Mou, L. :
Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning. J Reprod Dev 63:17-26, 2017. Pubmed reference: 27725344. DOI: 10.1262/jrd.2016-079.
2016 Butler, J.R., Martens, G.R., Li, P., Wang, Z.Y., Estrada, J.L., Ladowski, J.M., Tector, M., Tector, A.J. :
The fate of human platelets exposed to porcine renal endothelium: a single-pass model of platelet uptake in domestic and genetically modified porcine organs. J Surg Res 200:698-706, 2016. Pubmed reference: 26375504. DOI: 10.1016/j.jss.2015.08.034.
Cheng, W., Zhao, H., Yu, H., Xin, J., Wang, J., Zeng, L., Yuan, Z., Qing, Y., Li, H., Jia, B., Yang, C., Shen, Y., Zhao, L., Pan, W., Zhao, H.Y., Wang, W., Wei, H.J. :
Efficient generation of GGTA1-null Diannan miniature pigs using TALENs combined with somatic cell nuclear transfer. Reprod Biol Endocrinol 14:77, 2016. Pubmed reference: 27821126. DOI: 10.1186/s12958-016-0212-7.
Choi, K., Shim, J., Ko, N., Eom, H., Kim, J., Lee, J.W., Jin, D.I., Kim, H. :
Production of heterozygous alpha 1,3-galactosyltransferase (GGTA1) knock-out transgenic miniature pigs expressing human CD39. Transgenic Res , 2016. Pubmed reference: 27830476. DOI: 10.1007/s11248-016-9996-7.
Commins, S.P., Jerath, M.R., Cox, K., Erickson, L.D., Platts-Mills, T. :
Delayed anaphylaxis to alpha-gal, an oligosaccharide in mammalian meat. Allergol Int 65:16-20, 2016. Pubmed reference: 26666477. DOI: 10.1016/j.alit.2015.10.001.
Kang, J.T., Kwon, D.K., Park, A.R., Lee, E.J., Yun, Y.J., Ji, D.Y., Lee, K., Park, K.W. :
Production of α1,3-galactosyltransferase targeted pigs using transcription activator-like effector nuclease-mediated genome editing technology. J Vet Sci 17:89-96, 2016. Pubmed reference: 27051344. DOI: 10.4142/jvs.2016.17.1.89.
Petersen, B., Frenzel, A., Lucas-Hahn, A., Herrmann, D., Hassel, P., Klein, S., Ziegler, M., Hadeler, K.G., Niemann, H. :
Efficient production of biallelic GGTA1 knockout pigs by cytoplasmic microinjection of CRISPR/Cas9 into zygotes. Xenotransplantation 23:338-46, 2016. Pubmed reference: 27610605. DOI: 10.1111/xen.12258.
Priori, D., Colombo, M., Koopmans, S.J., Jansman, A.J., van der Meulen, J., Trevisi, P., Bosi, P. :
The A0 blood group genotype modifies the jejunal glycomic binding pattern profile of piglets early associated with a simple or complex microbiota. J Anim Sci 94:592-601, 2016. Pubmed reference: 27065129. DOI: 10.2527/jas.2015-9948.
2015 Estrada, J.L., Martens, G., Li, P., Adams, A., Newell, K.A., Ford, M.L., Butler, J.R., Sidner, R., Tector, M., Tector, J. :
Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes. Xenotransplantation 22:194-202, 2015. Pubmed reference: 25728481. DOI: 10.1111/xen.12161.
2013 Bradstreet, R.W., Toledo-Pereyra, L.H. :
Mechanisms of Gal-knockout pig cell selection for somatic cell nuclear transfer. J Surg Res , 2013. Pubmed reference: 23499396. DOI: 10.1016/j.jss.2013.02.007.
Li, P., Estrada, J.L., Burlak, C., Tector, A.J. :
Biallelic knockout of the α-1,3 galactosyltransferase gene in porcine liver-derived cells using zinc finger nucleases. J Surg Res 181:e39-45, 2013. Pubmed reference: 22795272. DOI: 10.1016/j.jss.2012.06.035.
Liu, Y., Yang, J.Y., Lu, Y., Yu, P., Dove, C.R., Hutcheson, J.M., Mumaw, J.L., Stice, S.L., West, F.D. :
α-1,3-Galactosyltransferase Knockout Pig Induced Pluripotent Stem Cells: A Cell Source for the Production of Xenotransplant Pigs. Cell Reprogram 15:107-16, 2013. Pubmed reference: 23402576. DOI: 10.1089/cell.2012.0062.
Miyagawa, S., Maeda, A., Takeishi, S., Ueno, T., Usui, N., Matsumoto, S., Okitsu, T., Goto, M., Nagashima, H. :
A lectin array analysis for wild-type and α-Gal-knockout pig islets versus healthy human islets. Surg Today , 2013. Pubmed reference: 23549931. DOI: 10.1007/s00595-013-0569-6.
Shimatsu, Y., Yamada, K., Horii, W., Hirakata, A., Sakamoto, Y., Waki, S., Sano, J., Saitoh, T., Sahara, H., Shimizu, A., Yazawa, H., Sachs, D.H., Nunoya, T. :
Production of cloned NIBS (Nippon Institute for Biological Science) and α-1, 3-galactosyltransferase knockout MGH miniature pigs by somatic cell nuclear transfer using the NIBS breed as surrogates. Xenotransplantation , 2013. Pubmed reference: 23581451. DOI: 10.1111/xen.12031.
Xin, J., Yang, H., Fan, N., Zhao, B., Ouyang, Z., Liu, Z., Zhao, Y., Li, X., Song, J., Yang, Y., Zou, Q., Yan, Q., Zeng, Y., Lai, L. :
Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs. PLoS One 8:e84250, 2013. Pubmed reference: 24358349. DOI: 10.1371/journal.pone.0084250.
2012 Burlak, C., Wang, Z.Y., Chihara, R.K., Lutz, A.J., Wang, Y., Estrada, J.L., Tector, A.J. :
Identification of human preformed antibody targets in GTKO pigs. Xenotransplantation 19:92-101, 2012. Pubmed reference: 22497511. DOI: 10.1111/j.1399-3089.2012.00695.x.
Ekser, B., Bianchi, J., Ball, S., Iwase, H., Walters, A., Ezzelarab, M., Veroux, M., Gridelli, B., Wagner, R., Ayares, D., Cooper, D.K. :
Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species. Xenotransplantation 19:342-54, 2012. Pubmed reference: 23145497. DOI: 10.1111/xen.12007.
Fang, J., Walters, A., Hara, H., Long, C., Yeh, P., Ayares, D., Cooper, D.K., Bianchi, J. :
Anti-gal antibodies in α1,3-galactosyltransferase gene-knockout pigs. Xenotransplantation 19:305-10, 2012. Pubmed reference: 22970769. DOI: 10.1111/j.1399-3089.2012.00710.x.
2011 Ekser, B., Gridelli, B., Veroux, M., Cooper, D.K. :
Clinical pig liver xenotransplantation: how far do we have to go? Xenotransplantation 18:158-67, 2011. Pubmed reference: 21696445. DOI: 10.1111/j.1399-3089.2011.00642.x.
Hara, H., Koike, N., Long, C., Piluek, J., Roh, D.S., SundarRaj, N., Funderburgh, J.L., Mizuguchi, Y., Isse, K., Phelps, C.J., Ball, S.F., Ayares, D.L., Cooper, D.K. :
Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs. Invest Ophthalmol Vis Sci 52:5278-86, 2011. Pubmed reference: 21596821. DOI: 10.1167/iovs.10-6947.
Nguyen, D.T., Choi, H., Jo, H., Kim, J.H., Dirisala, V.R., Lee, K.T., Kim, T.H., Park, K.K., Seo, K., Park, C. :
Molecular characterization of the human ABO blood group orthologus system in pigs. Anim Genet 42:325-8, 2011. Pubmed reference: 21554350. DOI: 10.1111/j.1365-2052.2010.02152.x.
Thompson, P., Badell, I.R., Lowe, M., Cano, J., Song, M., Leopardi, F., Avila, J., Ruhil, R., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Iwakoshi, N., Larsen, C.P., Kirk, A.D. :
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function. Am J Transplant 11:2593-602, 2011. Pubmed reference: 21883917. DOI: 10.1111/j.1600-6143.2011.03720.x.
2010 Martínez-Alarcón, L., Ramis, G., Majado, M.J., Quereda, J.J., Herrero-Medrano, J.M., Ríos, A., Ramírez, P., Muñoz, A. :
ABO and RH1 blood group phenotyping in pigs (Sus scrofa) using microtyping cards. Transplant Proc 42:2146-8, 2010. Pubmed reference: 20692429. DOI: 10.1016/j.transproceed.2010.05.105.
2009 Yeom, SC., Oh, BC., Cho, SY., Park, CG., Lee, BC., Lee, WJ. :
Investigation of blood typing method for seoul National University miniature pig. Transplant Proc 41:1921-6, 2009. Pubmed reference: 19545757. DOI: 10.1016/j.transproceed.2009.01.096.
2008 Fujimura, T., Murakami, H., Kurome, M., Takahagi, Y., Shigehisa, T., Nagashima, H. :
Effects of recloning on the efficiency of production of alpha 1,3-galactosyltransferase knockout pigs. J Reprod Dev 54:58-62, 2008. Pubmed reference: 18094530.
2003 Phelps, C.J., Koike, C., Vaught, T.D., Boone, J., Wells, K.D., Chen, S.H., Ball, S., Specht, S.M., Polejaeva, I.A., Monahan, J.A., Jobst, P.M., Sharma, S.B., Lamborn, A.E., Garst, A.S., Moore, M., Demetris, A.J., Rudert, W.A., Bottino, R., Bertera, S., Trucco, M., Starzl, T.E., Dai, Y., Ayares, D.L. :
Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 299:411-4, 2003. Pubmed reference: 12493821. DOI: 10.1126/science.1078942.
2002 Lai, L., Kolber-Simonds, D., Park, K.W., Cheong, H.T., Greenstein, J.L., Im, G.S., Samuel, M., Bonk, A., Rieke, A., Day, B.N., Murphy, C.N., Carter, D.B., Hawley, R.J., Prather, R.S. :
Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295:1089-92, 2002. Pubmed reference: 11778012. DOI: 10.1126/science.1068228.
2001 Yamamoto, F., Yamamoto, M. :
Molecular genetic basis of porcine histo-blood group AO system Blood 97:3308-3310, 2001. Pubmed reference: 11342465.
2000 Kobayashi, T., Yokoyama, I., Nagasaka, T., Namii, Y., Hayashi, S., Liu, D., Oikawa, T., Usami, T., Morozumi, K., Yamada, K., Haba, T., Tominaga, Y., Uchida, K., Takagi, H. :
Efficacy of double filtration plasmapheresis pretreatment in clinical ABO-incompatible transplantation and experimental pig-to-baboon xenotransplantation. Transplant Proc 32:57, 2000. Pubmed reference: 10700967.
1964 Rasmusen, B.A. :
Gene interaction and the A-O blood group system in pigs Genetics 50:191-198, 1964. Pubmed reference: 14191350.
1962 Andresen, E. :
Blood groups in pigs Annals of the New York Academy of Sciences 97:207-225, 1962. Pubmed reference: 13861461.
Saison, R., Ingham, D.G. :
A report on blood groups in pigs Annals of the New York Academy of Sciences 97:226-232, 1962. Pubmed reference: 14496091.
1958 Sprague, L.M. :
On the Recognition and Inheritance of the Soluble Blood Group Property "Oc" of Cattle. Genetics 43:906-12, 1958. Pubmed reference: 17247803.
1949 Chadwick, D.W., Smith, H. :
Serological characters of hog gastric mucin. Nature 164:61, 1949. Pubmed reference: 18133537.

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