OMIA:001089-9542 : Blood group system ABO in Macaca fuscata
In other species: olive baboon , pig , chimpanzee , Rhesus monkey , crab-eating macaque , agile gibbon , common gibbon , siamang
Categories: Haematopoietic system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 110300 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal co-dominant
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2000
Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars. The ABO blood group system arises from two alleles at a locus that encodes a glycosyltransferase: the A allele encodes alpha 1-3-N-acetylgalactosaminyltransferase; and the B allele encodes alpha 1-3-galactosyltransferase. The B allele transferase catalyses the addition of galactose to a chain of four sugars attached to a protein known as H antigen. The A allele ltransferase catalyses the addition of a derivative of galactose called N-acetylgalactosamine to the same short chain of sugars. The third allele at this locus (the O allele) results in no sugar being added to the chain.
Species-specific description: Only type B exists in this species.
Molecular basis: Noda et al. (2000) showed that the DNA sequence of the definitive region of the ABO gene in Japanese macaques is exactly the same as for allele B in rhesus macaques (OMIA 001089-9544) and crab-eating macaques (OMIA 001089-9541), i.e. allele B reflects the peptide haplotype p.266Met + p.268Ala.
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|ABO||Macaca fuscata||-||no genomic information (-..-)||ABO||Ensembl|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1177||Antigen B||ABO||haplotype||Naturally occurring variant||Allele B reflects the peptide haplotype p.266Met + p.268Ala||2000||10984838|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2023||Sano, R., Fukuda, H., Kubo, R., Oishi, T., Miyabe-Nishiwaki, T., Kaneko, A., Masato, H., Takahashi, Y., Hayakawa, A., Yazawa, S., Kominato, Y. :|
|Emergence of an erythroid cell-specific regulatory region in ABO intron 1 attributable to A- or B-antigen expression on erythrocytes in Hominoidea. Sci Rep 13:4947, 2023. Pubmed reference: 36973299 . DOI: 10.1038/s41598-023-31961-6.|
|2000||Noda, R., Kitano, T., Takenaka, O., Saitou, N. :|
|Evolution of the ABO blood group gene in Japanese macaque. Genes Genet Syst 75:141-7, 2000. Pubmed reference: 10984838 .|
|1968||Moor-Jankowski, J., Wiener, A.S. :|
|Blood groups of non-human primates. Summary of the currently available information. Primates Med 1:49-67, 1968. Pubmed reference: 4135382 .|
|1966||Nakajima, H. :|
|ABO and Lewis blood groups of Macaca fuscata (Japanese apes). Z Immunitatsforsch Allerg Klin Immunol 130:495-505, 1966. Pubmed reference: 4228972 .|
- Created by Frank Nicholas on 19 Oct 2011
- Changed by Frank Nicholas on 12 Dec 2011
- Changed by Frank Nicholas on 21 Mar 2012
- Changed by Frank Nicholas on 27 Nov 2013
- Changed by Frank Nicholas on 01 Apr 2020