OMIA:001089-9590 : Blood group system ABO in Symphalangus syndactylus (siamang)
Categories: Haematopoietic system phene
Possibly relevant human trait(s) and/or gene(s) (MIM number): 110300 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal co-dominant
Considered a defect: no
Key variant known: yes
Year key variant first reported: 2009
Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars. The ABO blood group system arises from two alleles at a locus that encodes a glycosyltransferase: the A allele encodes alpha 1-3-N-acetylgalactosaminyltransferase; and the B allele encodes alpha 1-3-galactosyltransferase. The B allele transferase catalyses the addition of galactose to a chain of four sugars attached to a protein known as H antigen. The A allele ltransferase catalyses the addition of a derivative of galactose called N-acetylgalactosamine to the same short chain of sugars. The third allele at this locus (the O allele) results in no sugar being added to the chain.
Have human generated variants been created, e.g. through genetic engineering and gene editing
|OMIA gene details page
|Homologene, Ensembl , NCBI gene
Cite this entry
|Kitano, T., Noda, R., Takenaka, O., Saitou, N. :
|Relic of ancient recombinations in gibbon ABO blood group genes deciphered through phylogenetic network analysis. Mol Phylogenet Evol 51:465-71, 2009. Pubmed reference: 19298858. DOI: 10.1016/j.ympev.2009.02.023.
- Created by Frank Nicholas on 19 Oct 2011
- Changed by Frank Nicholas on 12 Dec 2011
- Changed by Frank Nicholas on 21 Mar 2012