OMIA 001089-9544 : Blood group system ABO in Macaca mulatta

In other species: olive baboon , pig , Japanese macaque , chimpanzee , crab-eating macaque , agile gibbon , common gibbon , siamang

Possibly relevant human trait(s) and/or gene(s) (MIM number): 110300

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Co-Dominant

Considered a defect: no

Key variant known: yes

Year key variant first reported: 1998

Cross-species summary: Each blood group system consists of a set of blood types, each of which corresponds to a particular antigen (usually a glycoprotein) on the surface of red blood cells. The different types within a system are the result of the action of different alleles at a locus that usually encodes an enzyme that catalyses the creation of the feature of the glycoprotein unique to that type, e.g. the presence of a particular sugar at the end of a short chain of sugars. The ABO blood group system arises from two alleles at a locus that encodes a glycosyltransferase: the A allele encodes alpha 1-3-N-acetylgalactosaminyltransferase; and the B allele encodes alpha 1-3-galactosyltransferase. The B allele transferase catalyses the addition of galactose to a chain of four sugars attached to a protein known as H antigen. The A allele ltransferase catalyses the addition of a derivative of galactose called N-acetylgalactosamine to the same short chain of sugars. The third allele at this locus (the O allele) results in no sugar being added to the chain.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) Macaca mulatta 15 NC_027907.1 (5176290..5197022) ABO Homologene, Ensembl, NCBI gene

Variants

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Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Year Published PubMed ID(s) Acknowledgements
Blood group system ABO ABO missense 266; 268 1998 9583803

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2011 Premasuthan, A., Kanthaswamy, S., Satkoski, J., Smith, D.G. :
A simple multiplex polymerase chain reaction to determine ABO blood types of rhesus macaques (Macaca mulatta). Tissue Antigens 77:584-8, 2011. Pubmed reference: 21395559. DOI: 10.1111/j.1399-0039.2010.01602.x.
2009 Chen, S., Wei, Q., Li, J., Xiang, Y., Guo, H., Ichim, T.E., Chen, S., Chen, G. :
A simple and reliable method to blood type monkeys using serum samples. Transpl Int 22:999-1004, 2009. Pubmed reference: 19298252. DOI: 10.1111/j.1432-2277.2009.00859.x.
2008 Malaivijitnond, S., Sae-Low, W., Hamada, Y. :
The human-ABO blood groups of free-ranging long-tailed macaques (Macaca fascicularis) and parapatric rhesus macaques (M. mulatta) in Thailand. J Med Primatol 37:31-7, 2008. Pubmed reference: 18199070. DOI: 10.1111/j.1600-0684.2007.00223.x.
1999 Kermarrec, N., Roubinet, F., Apoil, P.A., Blancher, A. :
Comparison of allele O sequences of the human and non-human primate ABO system. Immunogenetics 49:517-26, 1999. Pubmed reference: 10380696.
1998 Doxiadis, G.G., Otting, N., Antunes, S.G., de Groot, N.G., Harvey, M., Doxiadis, I.I., Jonker, M., Bontrop, R.E. :
Characterization of the ABO blood group genes in macaques: evidence for convergent evolution. Tissue Antigens 51:321-6, 1998. Pubmed reference: 9583803.

Edit History


  • Created by Frank Nicholas on 19 Oct 2011
  • Changed by Frank Nicholas on 19 Oct 2011
  • Changed by Frank Nicholas on 12 Dec 2011