OMIA 001199-494514 : Coat colour, extension in Vulpes lagopus
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|MC1R||Vulpes lagopus||-||no genomic information (-..-)||MC1R||Ensembl|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|262||Blue coat colour||MC1R||Ed||missense||Naturally occurring variant||p.[(G5C);(F280C)]||The blue (Ed) allele is a haplotype comprising two missense variants (p.Gly5Cys and p.Phe280Cys) (Våge et al., 2005)||2005||15982782|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Tietgen, L., Hagen, I.J., Kleven, O., Bernardi, C.D., Kvalnes, T., Norén, K., Hasselgren, M., Wallén, J.F., Angerbjörn, A., Landa, A., Eide, N.E., Flagstad, Ø., Jensen, H. :|
|Fur colour in the Arctic fox: genetic architecture and consequences for fitness. Proc Biol Sci 288:20211452, 2021. Pubmed reference: 34583587. DOI: 10.1098/rspb.2021.1452.|
|2016||Liu, Z., Gong, Y., Feng, M., Duan, L., Li, Y., Li, X. :|
|Genetic variations of the coding region of the melanocortin receptor 1 (MC1R) gene in the fox. Vet Dermatol 27:135-e36, 2016. Pubmed reference: 27072328. DOI: 10.1111/vde.12303.|
|2013||Nowacka-Woszuk, J., Salamon, S., Gorna, A., Switonski, M. :|
|Missense polymorphisms in the MC1R gene of the dog, red fox, arctic fox and Chinese raccoon dog. J Anim Breed Genet 130:136-41, 2013. Pubmed reference: 23496014. DOI: 10.1111/jbg.12005.|
|Switonski, M., Mankowska, M., Salamon, S. :|
|Family of melanocortin receptor (MCR) genes in mammals-mutations, polymorphisms and phenotypic effects. J Appl Genet 54:461-72, 2013. Pubmed reference: 23996627. DOI: 10.1007/s13353-013-0163-z.|
|2005||Vage, DI., Fuglei, E., Snipstad, K., Beheim, J., Landsem, VM., Klungland, H. :|
|Two cysteine substitutions in the MC1R generate the blue variant of the Arctic fox (Alopex lagopus) and prevent expression of the white winter coat. Peptides 26:1814-7, 2005. Pubmed reference: 15982782. DOI: 10.1016/j.peptides.2004.11.040.|
|1987||Adalsteinsson, S., Hersteinsson, P., Gunnarsson, E. :|
|Fox colors in relation to colors in mice and sheep Journal of Heredity 78:235-237, 1987. Pubmed reference: 3624844.|
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