OMIA 001199-10047 : Coat colour, extension in Meriones unguiculatus

In other species: , coyote , dog , red fox , American black bear , domestic cat , jaguar , ass , horse , pig , Arabian camel , reindeer , cattle , goat , sheep , rabbit , domestic guinea pig , domestic yak , alpaca , gray squirrel , woolly mammoth , rock pocket mouse , oldfield mouse , lesser earless lizard , Geoffroy's cat , Kodkod , jaguarundi , Colocolo , little striped whiptail , water buffalo , Arctic fox

Possibly relevant human trait(s) and/or gene(s) (MIM number): 266300

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Key variant known: no

Cross-species summary: The extension locus encodes the melanocyte-stimulating hormone receptor (MSHR; also known as MC1R). This receptor controls the level of tyrosinase within melanocytes. Tyrosinase is the limiting enzyme involved in synthesis of melanins: high levels of tyrosinase result in the production of eumelanin (dark colour, e.g. brown or black), while low levels result in the production of phaeomelanin (light colour, e.g. red or yellow). When melanocyte-stimulating hormone (MSH) binds to its receptor, the level of tyrosinase is increased, leading to production of eumelanin. The wild-type allele at the extension locus corresponds to a functional MSHR, and hence to dark pigmentation in the presence of MSH.

Reference


2007 Petrij, F., Mettler, M., Brückmann, V., van Veen, K. :
Recessive yellow in the Mongolian gerbil (Meriones unguiculatus) Journal of Experimental Animal Science 43:319-327, 2007. DOI: 10.1016/j.jeas.2006.09.006.

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  • Created by Frank Nicholas on 06 May 2019