In other species: Rhesus monkey , dog , American black bear , domestic cat , leopard , horse , pig , taurine cattle , goat , sheep , rabbit , golden hamster , North American deer mouse , Mongolian gerbil

Categories: Pigmentation phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 612271 (trait) , 203290 (trait) , 115501 (gene)

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal recessive

Disease-related: no

Key variant known: yes

Year key variant first reported: 2016

Species-specific description: The following summary has been provide by Cirera et al. (2016): "In American mink (Neovison vison), a total of 12 phenotypes display a brown appearance in a wide range (Nes et al., 1988). . . . The various brown coat colours in American mink have a brownish appearance that can vary within the phenotype but also during the animal life. However, for commercial purposes the colours are recorded at the pelting time, which is when the fur colour has reached its “maturity”. One important colour in the brown spectrum of mink is American Palomino (AP) . . . symbolized as kk in the Scandinavian nomenclature and b^p b^p in the American nomenclature (Nes et al. 1988). The AP mutant appeared first in a farm in Canada in the middle of the twentieth century (King 1951). The coat colour appears as a clear pale tan, and on a prime pelt it easily turns slightly red while the eyes are pink or red (Nes et al. 1988).

Inheritance: "All brown phenotypes are inherited as a simple recessive trait, thus only homozygous individuals display the phenotype." (Cirera et al., 2016)

Mapping: Based on mink sequence homology to human and dog (Graphodatsky et al. 2000; Hameister et al. 1997), the gene and sequences were located by Cirera et al. (2016) to mink chromosome 2, close to the centromere.

Molecular basis: Sequencing of the positional/functional candidate gene TRYP1 revealed the likely causal variant of the Palomino coat colour to be an insert of approximately 8kb at the beginning of intron 2, which is likely to disrupt slicing (Cicera et al., 2016)

Associated gene: