OMIA 001249-9925 : Coat colour, brown, TYRP1-related in Capra hircus
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|TYRP1||tyrosinase-related protein 1||Capra hircus||-||no genomic information (-..-)||TYRP1||Ensembl|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|1059||Toggenburg Valais Copperneck||Brown||TYRP1||missense||Naturally occurring variant||ARS1||8||g.31503165C>T||c.1487G>A||p.(G496D)||2015||25392961||The genomic location on ARS1 was determined by Katie Eager, EMAI, NSW Department of Primary Industries|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Henkel, J., Dubacher, A., Bangerter, E., Herren, U., Ammann, P., Drögemüller, C., Flury, C., Leeb, T. :|
|Introgression of ASIP and TYRP1 alleles explains coat color variation in Valais goats. J Hered 112:452-457, 2021. Pubmed reference: 34050662. DOI: 10.1093/jhered/esab024.|
|2015||Becker, D., Otto, M., Ammann, P., Keller, I., Drögemüller, C., Leeb, T. :|
|Corrigendum. Anim Genet 46:470, 2015. Pubmed reference: 26207940. DOI: 10.1111/age.12308.|
|Becker, D., Otto, M., Ammann, P., Keller, I., Drögemüller, C., Leeb, T. :|
|The brown coat colour of Coppernecked goats is associated with a non-synonymous variant at the TYRP1 locus on chromosome 8. Anim Genet 46:50-4, 2015. Pubmed reference: 25392961. DOI: 10.1111/age.12240.|
|Dietrich, J., Menzi, F., Ammann, P., Drögemüller, C., Leeb, T. :|
|A breeding experiment confirms the dominant mode of inheritance of the brown coat colour associated with the (496) Asp TYRP1 allele in goats. Anim Genet 46:587-8, 2015. Pubmed reference: 26153465. DOI: 10.1111/age.12320.|
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