OMIA 001249-9615 : Coat colour, brown, TYRP1-related in Canis lupus familiaris
Gerding et al. (2011) showed that the typical "grey" coat colour in Weimaraners is due to homozygosity for a non-functional allele (or heterozygosity for different non-functional alleles) at the TYRP1 locus; and that the "blue" coat colour in the same breed is due to the presence of one or two functional alleles at this locus. Thus, "blue" is dominant to "grey". By studying haplotypes, they were also able to show that the funcational allele is not a "reversion" from within the breed.
Letko and Drögemüller (2017) identified alleles b^c and b^d in Leonberger dogs.
Hrckova Turnova et al. (2017) reported a new allele (c.555T>G; p.Tyr185*) in a single pedigree of Australian Shepherd dogs.
Jancuskova et al. (2018) reported the same c.555T>G allele as being more widespread in the Australian Shepherd breed and "also its close relative Miniature American Shepherd".
Wright et al. (2019) reported a likely causal variant (CFA11:33326719; c.1025T>G; p.Phe342Cys) strongly associated with liver colour in Lancashire Heelers.
Van Buren et al. (2021) reported a 6th variant: "(NM_001194966.1, c.125G>A, p.Cys42Tyr) in exon 1 of the husky and husky‐mixes whose brown phenotype could not be explained by the previously known b‐variants." They named this variant b^h.Prevalence: Van Buren et al. (2021): "All genotyped brown husky and husky‐mixes carrying the b^h allele were compound heterozygotes with either the bs or bc alleles, consistent with two mutant alleles required for a brown coat. No unrelated huskies had the b^h allele." Breeds: Australian Shepherd, German Shepherd Dog, Leonberger, Miniature American Shepherd. Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|TYRP1||tyrosinase-related protein 1||Canis lupus familiaris||11||NC_051815.1 (34222689..34240515)||TYRP1||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
|Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Year Published||PubMed ID(s)||Acknowledgements|
|Numerous breeds||Brown||TYRP1||b^c||missense||CanFam3.1||11||g.33317810T>A||c.121T>A||p.Cys41Ser||2002||12140685||Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool. Correction to genomic details provided by professor Claire Wade August 2018. Correction to g and c. details provided by Professor Tosso Leeb 11 Feb 2020.|
|Siberian Husky||Brown||TYRP1||b^h||missense||CanFam3.1||11||g.33317814G>A||c.125G>A||p.Cys42Tyr||NM_001194966.1, c.125G>A, p.Cys42Tyr (Van Buren et al., 2021)||2021||33421162|
|Australian Shepherd||Brown||TYRP1||nonsense (stop-gain)||CanFam3.1||11||g.33319349T>G||c.555T>G||p.Tyr185*||2017||28497851|
|Numerous breeds||Brown||TYRP1||b^s||nonsense (stop-gain)||CanFam3.1||11||g.33326685C>T||c.991C>T||p.Gln331*||rs850566878||2002||12140685||Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool|
|Numerous breeds||Brown||TYRP1||b^d||deletion, small (<=20)||CanFam3.1||11||g.33326727_33326729del||c.1,033_1,035del||p.Pro345del||rs851422848||2002||12140685|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2021||Van Buren, S.L., Mickelson, J.R., Minor, K.M. :|
|A novel TYRP1 mutation associated with brown coat color in Siberian huskies. Anim Genet :, 2021. Pubmed reference: 33421162. DOI: 10.1111/age.13037.|
|2019||Wright, H.E., Schofield, E., Mellersh, C.S., Burmeister, L.M., Wright, H.E., Schofield, E., Mellersh, C.S., Burmeister, L.M. :|
|A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers. Anim Genet :, 2019. Pubmed reference: 31468558. DOI: 10.1111/age.12839.|
|van Rooy, D., Wade, C.M. :|
|Association between coat colour and the behaviour of Australian Labrador retrievers. Canine Genet Epidemiol 6:10, 2019. Pubmed reference: 31798910. DOI: 10.1186/s40575-019-0078-z.|
|2018||Jancuskova, T., Langevin, M., Pekova, S. :|
|TYRP1:c.555T>G is a recurrent mutation found in Australian Shepherd and Miniature American Shepherd dogs. Anim Genet :, 2018. Pubmed reference: 30109695. DOI: 10.1111/age.12709.|
|2017||Hrckova Turnova, E., Majchrakova, Z., Bielikova, M., Soltys, K., Turna, J., Dudas, A. :|
|A novel mutation in the TYRP1 gene associated with brown coat colour in the Australian Shepherd Dog Breed. Anim Genet 48:626, 2017. Pubmed reference: 28497851. DOI: 10.1111/age.12563.|
|Letko, A., Drögemüller, C. :|
|Two brown coat colour-associated TYRP1 variants (b(c) and b(d) ) occur in Leonberger dogs. Anim Genet 48:732-733, 2017. Pubmed reference: 28983931. DOI: 10.1111/age.12612.|
|2015||Monteagudo, L.V., Tejedor, M.T. :|
|The b(c) allele of TYRP1 is causative for the recessive brown (liver) colour in German Shepherd dogs. Anim Genet 46:588-9, 2015. Pubmed reference: 26370740. DOI: 10.1111/age.12337.|
|2012||Schmutz, S.M., Melekhovets, Y. :|
|Coat color DNA testing in dogs: theory meets practice. Mol Cell Probes 26:238-42, 2012. Pubmed reference: 22507852. DOI: 10.1016/j.mcp.2012.03.009.|
|2011||Gerding, WM., Schreiber, S., Dekomien, G., Epplen, JT. :|
|Tracing the origin of 'blue Weimaraner' dogs by molecular genetics. J Anim Breed Genet 128:153-60, 2011. Pubmed reference: 21385230. DOI: 10.1111/j.1439-0388.2010.00888.x.|
|2005||Cargill, E.J., Famula, T.R., Schnabel, R.D., Strain, G.M., Murphy, K.E. :|
|The color of a Dalmatian's spots: linkage evidence to support the TYRP1 gene. BMC Vet Res 1:1, 2005. Pubmed reference: 16045797. DOI: 10.1186/1746-6148-1-1.|
|2002||Schmutz, S.M., Berryere, T.G., Goldfinch, A.D. :|
|TYRP1 and MC1R genotypes and their effects on coat color in dogs Mammalian Genome 13:380-387, 2002. Pubmed reference: 12140685. DOI: 10.1007/s00335-001-2147-2.|
|1957||Little, C.C. :|
|The Inheritance of Coat Color in Dogs Comstock Publishing Associates, Cornell University Press, Ithaca, NY :, 1957.|
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