OMIA 001249-9685 : Coat colour, brown, TYRP1-related in Felis catus
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|TYRP1||tyrosinase-related protein 1||Felis catus||D4||NC_018735.3 (40068827..40087673)||TYRP1||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
|Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Year Published||PubMed ID(s)||Acknowledgements|
|Chocolate||TYRP1||b||splicing||p.Ala420_Asp421ins17/18||Lyons et al. (2005): "An intron 6 mutation that potentially disrupts the exon 6 downstream splice-donor recognition site" Li et al. (2018; Pigment Cell Melanoma Res., 1–10): "donor splice site mutation. p.Ala420_Asp421ins17/18"||2005||16104383|
|Cinnamon (light brown)||TYRP1||b1||nonsense (stop-gain)||c.298C>T||p.R100*||2005||16104383|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2005||Lyons, LA., Foe, IT., Rah, HC., Grahn, RA. :|
|Chocolate coated cats: TYRP1 mutations for brown color in domestic cats. Mamm Genome 16:356-66, 2005. Pubmed reference: 16104383.|
|Schmidt-Küntzel, A., Eizirik, E., O'Brien, S.J., Menotti-Raymond, M. :|
|Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. J Hered 96:289-301, 2005. Pubmed reference: 15858157. DOI: 10.1093/jhered/esi066.|
|1963||Todd, N.B. :|
|Independent assortment of Manx and three coat colour mutants in the domestic cat Journal of Heredity 54:266-272, 1963. Pubmed reference: 14098315.|
- Created by Frank Nicholas on 26 Nov 2007
- Changed by Frank Nicholas on 09 Dec 2011
- Changed by Frank Nicholas on 26 Nov 2012