OMIA 000439-9615 : Hair, long in Canis lupus familiaris
By conducting a GWAS on "903 dogs from 80 breeds with eight to 12 dogs unrelated at the grandparent level chosen to represent each breed", each dog genotyped with an Affymetrix Version 2 Canine SNP chip (yielding 40,812 informative SNPs for analysis), Cadieu et al. (2009) highlighted the region on chromosome CFA32 that contains the FGF5 gene, a mutation in which had been shown to be causal of hair length by Housley and Venta (2006) (see Molecular Basis section).Molecular basis: Using the candidate-gene approach, Housley and Venta (2006) sequenced the FGF5 gene in short- and long-haired dogs, and revealed the causative mutation to be "a missense mutation, resulting in the substitution of Phe for Cys, in a highly conserved region. Genotyping of 218 dogs from three breeds fixed for long hair, eight breeds fixed for short hair and five breeds in which long hair is segregating provided evidence that the missense mutation is associated with the hair-length differences among these breeds." Cadieu et al. (2009) confirmed this causal mutation.
Dierks et al. (2013) "detected three novel mutations in the coding sequence and one novel non-coding splice-site mutation in FGF5 associated with the long-hair phenotype".Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|FGF5||fibroblast growth factor 5||Canis lupus familiaris||32||NC_006614.3 (4508810..4529449)||FGF5||Homologene, Ensembl, NCBI gene|
By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.
WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
|Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Year Published||PubMed ID(s)||Acknowledgements|
|Afghan Hound Eurasier||Long hair||FGF5||duplication||CanFam 3.1||32||c.559_560dupGG||p.R188Afs*73||2013||23384345|
|Eurasier||Long hair||FGF5||deletion, small (<=20)||CanFam3.1||32||c.556_571del16||p.A186Tfs*69||2013||23384345|
|Afghan Hound Border Collie Cocker Spaniel Collie Corgi Dachshund German Shepherd Dog Golden Retriever Pomeranian Samoyed||Long hair||FGF5||missense||CanFam3.1||32||g.4509367G>T||c.284G>T||p.C95F||2006||16879338||Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool|
|Akita Samoyed Siberian Huskie||Long hair||FGF5||missense||CanFam3.1||32||g.4528639C>T||c.578C>T||p.A193V||2013||23384345||Variant coordinates obtained from or confirmed by EBI's Some Effect Predictor (VEP) tool|
|Afghan Hound||Long hair||FGF5||splicing||CanFam3.1||32||g.8193T>A||2013||23384345|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2017||Parker, H.G., Harris, A., Dreger, D.L., Davis, B.W., Ostrander, E.A. :|
|The bald and the beautiful: hairlessness in domestic dog breeds. Philos Trans R Soc Lond B Biol Sci 372:, 2017. Pubmed reference: 27994129. DOI: 10.1098/rstb.2015.0488.|
|2013||Dierks, C., Mömke, S., Philipp, U., Distl, O. :|
|Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs. Anim Genet 44:425-31, 2013. Pubmed reference: 23384345. DOI: 10.1111/age.12010.|
|2009||Cadieu, E., Neff, M.W., Quignon, P., Walsh, K., Chase, K., Parker, H.G., Vonholdt, B.M., Rhue, A., Boyko, A., Byers, A., Wong, A., Mosher, D.S., Elkahloun, A.G., Spady, T.C., André, C., Lark, K.G., Cargill, M., Bustamante, C.D., Wayne, R.K., Ostrander, E.A. :|
|Coat variation in the domestic dog is governed by variants in three genes. Science 326:150-3, 2009. Pubmed reference: 19713490. DOI: 10.1126/science.1177808.|
|2008||Jones, P., Chase, K., Martin, A., Davern, P., Ostrander, EA., Lark, KG. :|
|Single-nucleotide-polymorphism-based association mapping of dog stereotypes. Genetics 179:1033-44, 2008. Pubmed reference: 18505865. DOI: 10.1534/genetics.108.087866.|
|2006||Housley, DJ., Venta, PJ. :|
|The long and the short of it: evidence that FGF5 is a major determinant of canine 'hair'-itability. Anim Genet 37:309-15, 2006. Pubmed reference: 16879338. DOI: 10.1111/j.1365-2052.2006.01448.x.|
|2005||Schrameyer, T., Dekomien, G., Pasternack, S.M., Reinartz, B.S., Santos, E.J., Epplen, J.T. :|
|Long- and short-haired Weimaraner dogs represent two populations of one breed. Electrophoresis 26:1668-72, 2005. Pubmed reference: 15812847. DOI: 10.1002/elps.200410204.|
|1978||Crawford, R.D., Loomis, G. :|
|Inheritance of short coat and long coat in St. Bernard dogs Journal of Heredity 69:266-267, 1978. Pubmed reference: 731015.|
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