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OMIA:000683-143350 : Muscular hypertrophy (double muscling) in Pagrus major (red seabream)

In other species: Japanese flounder , Mallard , rock pigeon , chicken , dog , pig , taurine cattle , goat , sheep , rabbit , water buffalo , Japanese quail , yellow catfish

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: yes

Disease-related: no

Key variant known: yes

Year key variant first reported: 2018

Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)

Species-specific description: Kishimoto et al. (2018) used CRISPR/Cas9 technology to create myostatin (Pm-mstn) complete knockout red sea bream. This study involves gene edited or genetically modified organisms (GMO).  

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
MSTN Pagrus major - no genomic information (-..-) MSTN Ensembl

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000683-143350: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Murakami, Y., Ando, M., Kishimoto, K., Ohama, M., Uemura, Y., Tani, R., Akazawa, A., Matsumiya, K., Sato, K., Kinoshita, M. :
Alterations in the fillet quality of myostatin-knockout red sea bream Pagrus major: Preliminary insights into nutritional, compositional, and textural properties. Heliyon 10:e32242, 2024. Pubmed reference: 38873675. DOI: 10.1016/j.heliyon.2024.e32242.
2018 Kishimoto, K., Washio, Y., Yoshiura, Y., Toyoda, A., Ueno, T., Fukuyama, H., Kato, K., Kinoshita, M. :
Production of a breed of red sea bream Pagrus major with an increase of skeletal muscle mass and reduced body length by genome editing with CRISPR/Cas9. Aquaculture 495:415-427, 2018. DOI: 10.1016/j.aquaculture.2018.05.055.

Edit History


  • Created by Imke Tammen2 on 11 Sep 2024
  • Changed by Imke Tammen2 on 11 Sep 2024