OMIA:000683-8839 : Muscular hypertrophy (double muscling) in Anas platyrhynchos (Mallard) |
In other species: Japanese flounder , rock pigeon , chicken , dog , pig , taurine cattle , goat , sheep , rabbit , water buffalo , Japanese quail , red seabream , yellow catfish
Categories: Muscle phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: yes
Disease-related: unknown
Key variant known: yes
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: Lee et al. (2022) "injected the adenovirus containing the CRISPR-Cas9 system with the guide RNA (gRNA) targeting ... the myostatin (MSTN) gene, termed Adeno-MSTN, into ... duck blastoderms, ... and confirmed genome editing in their offspring." This study involves gene edited or genetically modified organisms (GMO).
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000683-8839: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2024 | Lee, J., Kim, D.H., Lee, K. : |
Myostatin gene role in regulating traits of poultry species for potential industrial applications. J Anim Sci Biotechnol 15:82, 2024. Pubmed reference: 38825693. DOI: 10.1186/s40104-024-01040-5. | |
2022 | Lee, J., Kim, D.H., Karolak, M.C., Shin, S., Lee, K. : |
Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing. Proc Natl Acad Sci U S A 119:e2214344119, 2022. Pubmed reference: 36322747. DOI: 10.1073/pnas.2214344119. |
Edit History
- Created by Imke Tammen2 on 07 Sep 2024
- Changed by Imke Tammen2 on 07 Sep 2024