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OMIA:000683-8839 : Muscular hypertrophy (double muscling) in Anas platyrhynchos (Mallard)

In other species: Japanese flounder , rock pigeon , chicken , dog , pig , taurine cattle , goat , sheep , rabbit , water buffalo , Japanese quail , red seabream , yellow catfish

Categories: Muscle phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)

Links to relevant human diseases in MONDO:

Mendelian trait/disorder: yes

Disease-related: unknown

Key variant known: yes

Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)

Species-specific description: Lee et al. (2022) "injected the adenovirus containing the CRISPR-Cas9 system with the guide RNA (gRNA) targeting ... the myostatin (MSTN) gene, termed Adeno-MSTN, into ... duck blastoderms, ... and confirmed genome editing in their offspring." This study involves gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000683-8839: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2024 Lee, J., Kim, D.H., Lee, K. :
Myostatin gene role in regulating traits of poultry species for potential industrial applications. J Anim Sci Biotechnol 15:82, 2024. Pubmed reference: 38825693. DOI: 10.1186/s40104-024-01040-5.
2022 Lee, J., Kim, D.H., Karolak, M.C., Shin, S., Lee, K. :
Generation of genome-edited chicken and duck lines by adenovirus-mediated in vivo genome editing. Proc Natl Acad Sci U S A 119:e2214344119, 2022. Pubmed reference: 36322747. DOI: 10.1073/pnas.2214344119.

Edit History


  • Created by Imke Tammen2 on 07 Sep 2024
  • Changed by Imke Tammen2 on 07 Sep 2024