OMIA:000683-9031 : Muscular hypertrophy (double muscling) in Gallus gallus (chicken) |
In other species: Japanese flounder , Mallard , rock pigeon , dog , pig , taurine cattle , goat , sheep , rabbit , pacu , water buffalo , Japanese quail , red seabream , yellow catfish
Categories: Muscle phene
Links to possible relevant human trait(s) and/or gene(s) in OMIM: 601788 (gene) , 614160 (trait)
Links to relevant human diseases in MONDO:
Mendelian trait/disorder: unknown
Disease-related: no
Cross-species summary: Abnormal increase in muscular tissue caused entirely by enlargement of existing cells (in contrast to muscular hyperplasia, in which the abnormal increase in muscular tissue is due to the formation and growth of new, normal muscle cells)
Species-specific description: This is a genetically-modified organism; GMO
Genetic engineering:
Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| MSTN | myostatin | Gallus gallus | 7 | NC_052538.1 (305390..312076) | MSTN | Homologene, Ensembl , NCBI gene |
Cite this entry
Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:000683-9031: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2024 | Lee, J., Kim, D.H., Lee, K. : |
| Myostatin gene role in regulating traits of poultry species for potential industrial applications. J Anim Sci Biotechnol 15:82, 2024. Pubmed reference: 38825693. DOI: 10.1186/s40104-024-01040-5. | |
| 2021 | Petry, B., Moreira, G.C.M., Copola, A.G.L., de Souza, M.M., da Veiga, F.C., Jorge, E.C., de Oliveira Peixoto, J., Ledur, M.C., Koltes, J.E., Coutinho, L.L. : |
| SAP30 gene is a probable regulator of muscle hypertrophy in chickens. Front Genet 12:709937, 2021. Pubmed reference: 34646299. DOI: 10.3389/fgene.2021.709937. | |
| 2020 | Kim, G.D., Lee, J.H., Song, S., Kim, S.W., Han, J.S., Shin, S.P., Park, B.C., Park, T.S. : |
| Generation of myostatin-knockout chickens mediated by D10A-Cas9 nickase. FASEB J 34:5688-5696, 2020. Pubmed reference: 32100378. DOI: 10.1096/fj.201903035R. | |
| 2018 | Aiello, D., Patel, K., Lasagna, E. : |
| The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals. Anim Genet 49:505-19, 2018. Pubmed reference: 30125951. DOI: 10.1111/age.12696. | |
| 2017 | Bhattacharya, T.K., Shukla, R., Chatterjee, R.N., Dushyanth, K. : |
| Knock down of the myostatin gene by RNA interference increased body weight in chicken. J Biotechnol 241:S0168-1656(16)31612-1:61-68, 2017. Pubmed reference: 27845166. DOI: 10.1016/j.jbiotec.2016.11.012. | |
| 2002 | Mott, I., Ivarie, R. : |
| Expression of myostatin is not altered in lines of poultry exhibiting myofiber hyper- and hypoplasia. Poult Sci 81:799-804, 2002. Pubmed reference: 12079046. DOI: 10.1093/ps/81.6.799. |
Edit History
- Created by Frank Nicholas on 18 Nov 2016
- Changed by Imke Tammen2 on 30 Aug 2021
- Changed by Imke Tammen2 on 19 Oct 2021
- Changed by Imke Tammen2 on 12 Dec 2023