OMIA 000944-9685 : Spongiform encephalopathy in Felis catus

In other species: chicken , white-tufted-ear marmoset , macaques , crab-eating macaque , Rhesus monkey , dog , domestic ferret , puma , horse , pig , deer , Western roe deer , Eastern wapiti , Manchurian Wapiti , black-tailed deer , , cattle , goat , , sheep , eland , greater kudu , rabbit , golden hamster , domestic guinea pig , fallow deer , cheetah , blue antelope , Arabian oryx , , water buffalo , , , American mink ,

Possibly relevant human trait(s) and/or gene(s) (MIM number): 176640

Mendelian trait/disorder: unknown

Considered a defect: yes

Cross-species summary: Spongiform encephalopathies are a class of fatal neurological diseases. Clinical signs are characteristic of a progressive degeneration of the central nervous system; they include pruritis, abnormalities of gait and recumbency. Death is inevitable. On post-mortem, brain histopathology shows a characteristic spongy appearance. The infectious agent is a modified form of a protein encoded by a gene in the host. The name given to this infectious particle is prion. The host gene is called the prion protein (PrP) gene, which is a normal part of the genome of mammals and chickens. Its polypeptide product, called cellular PrP(superscript C), is a naturally-occurring protein attached to the outer surface of neurones and some other cells. PrP(superscript C) appears to play a role in maintaining the Purkinje cells of the cerebellum, which are essential for balance and muscular function. The infectious agent, called scrapie PrP(superscript Sc), is a modifed form of PrP(superscript C), where the modifications involve glycosylation and the creation of intra-strand di-sulphide bonds. It is important to realise that these modifications involve no change in amino acid sequence. When PrP(superscript Sc) molecules enter a previously uninfected host, they convert the naturally occurring PrP(superscript C) molecules, produced by the host gene, into infectious PrP(superscript Sc) particles, which ultimately cause clinical signs in that animal, and which can spread to other animals, both horizontally (by infection) and vertically (by maternal transmission).

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2015 Aguilar-Calvo, P., GarcĂ­a, C., Espinosa, J.C., Andreoletti, O., Torres, J.M. :
Prion and prion-like diseases in animals. Virus Res 207:82-93, 2015. Pubmed reference: 25444937. DOI: 10.1016/j.virusres.2014.11.026.
2012 Stewart, P., Campbell, L., Skogtvedt, S., Griffin, K.A., Arnemo, J.M., Tryland, M., Girling, S., Miller, M.W., Tranulis, M.A., Goldmann, W. :
Genetic predictions of prion disease susceptibility in carnivore species based on variability of the prion gene coding region. PLoS One 7:e50623, 2012. Pubmed reference: 23236380. DOI: 10.1371/journal.pone.0050623.
2005 Kelly, DF., Wells, GA., Haritani, M., Higgins, RJ., Jeffrey, M. :
Neuropathological findings in cats with clinically suspect but histologically unconfirmed feline spongiform encephalopathy. Vet Rec 156:472-7, 2005. Pubmed reference: 15828743.
2002 Demierre, S., Botteron, C., Cizinauskas, S., Doherr, M.G., Fatzer, R., Jaggy, A. :
Feline spongiform encephalopathy: first clinical case in Switzerland Schweizer Archiv fur Tierheilkunde 144:550-557, 2002. Pubmed reference: 12442705.
Heim, D., Geiser, F., Perler, L., Wyss, R. :
Beyond BSE: Transmissible spongiform encephalopathies in other species Schweizer Archiv fur Tierheilkunde 144:664-673, 2002. Pubmed reference: 12585207.
2001 Ryder, S.J., Wells, G.A.H., Bradshaw, J.M., Pearson, G.R. :
Inconsistent detection of PrP in extraneural tissues of cats with feline spongiform encephalopathy Veterinary Record 148:437-441, 2001. Pubmed reference: 11338713.
1998 Zanusso, G., Nardelli, E., Rosati, A., Fabrizi, G.M., Ferrari, S., Carteri, A., Desimone, F., Rizutto, N., Monaco, S. :
Simultaneous occurrence of spongiform encephalopathy in a man and his cat in italy Lancet 352:1116-1117, 1998. Pubmed reference: 9798590. DOI: 10.1016/S0140-6736(05)79756-7.
1996 Anon. :
Feline spongiform encephalopathy Journal of Small Animal Practice 37:198-199, 1996. Pubmed reference: 8731410.
Collinge, J., Sidle, K.C.L., Meads, J., Ironside, J., Hill, A.F. :
Molecular analysis of prion strain variation and the aetiology of new variant CJD Nature 383:685-690, 1996. Pubmed reference: 8878476. DOI: 10.1038/383685a0.
Glavits, R., Ratz, F. :
Studies on the spongiform encephalopathies of cattle, sheep and cats (BSE, scrapie, FSE) in the Hungarian diagnostic institutes [Hungarian] Magyar Allatorvosok Lapja 51:529-531, 1996.
1995 Bratberg, B., Ueland, K., Wells, G.A.H. :
Feline spongiform encephalopathy in a cat in Norway Veterinary Record 136:444, 1995. Pubmed reference: 7631481.
1994 Fraser, H., Pearson, G.R., McConnell, I., Bruce, M.E., Wyatt, J.M., Gruffydd-Jones, T.J. :
Transmission of Feline Spongiform Encephalopathy to Mice Veterinary Record 134:449, 1994. Pubmed reference: 8048218.
Groschup, M.H., Langeveld, J., Pfaff, E. :
The major species specific epitope in prion proteins of ruminants Archives of Virology 136:423-431, 1994. Pubmed reference: 7518226.
Hewickertrautwein, M. :
Feline Spongiform Encephalopathy Kleintierpraxis 39:855, 1994.
1993 Wyatt, J.M., Pearson, G.R., Gruffydd-Jones, T.J. :
Feline Spongiform Encephalopathy Feline Practice 21:7-9, 1993.
1992 Gruffydd-Jones, T.J., Galloway, P.E., Pearson, G.R. :
Feline Spongiform Encephalopathy Journal of Small Animal Practice 33:471-476, 1992.
Moennig, V. :
Mad Cow Disease in Cats Tijdschrift Voor Diergeneeskunde 117:412-413, 1992. Pubmed reference: 1641835.
Pearson, G.R., Wyatt, J.M., Gruffydd-Jones, T.J., Hope, J., Chong, A., Higgins, R.J., Scott, A.C., Wells, G.A.H. :
Feline Spongiform Encephalopathy - Fibril and PrP Studies Veterinary Record 131:307-310, 1992. Pubmed reference: 1279883.
Wells, G.A.H., Mcgill, I.S. :
Recently Described Scrapie-Like Encephalopathies of Animals - Case Definitions - Review Article Research in Veterinary Science 53:1-10, 1992. Pubmed reference: 1410804.
1991 Pearson, G.R., Gruffydd-Jones, T.J., Wyatt, J.M., Hope, J., Chong, A., Scott, A.C., Dawson, M., Wells, G.A.H. :
Feline Spongiform Encephalopathy Veterinary Record 128:532, 1991. Pubmed reference: 1866888.
Synge, B.A., Waters, J.W. :
Spongiform Encephalopathy in a Scottish Cat Veterinary Record 129:320, 1991. Pubmed reference: 1801815.
Wyatt, J.M. :
Naturally Occurring Spongiform Encephalopathy in Cats in the UK Australian Veterinary Practitioner 21:174-176, 1991.
Wyatt, J.M., Pearson, G.R., Smerdon, T.N., Gruffydd-Jones, T.J., Wells, G.A.H., Wilesmith, J.W. :
Naturally Occurring Scrapie-Like Spongiform Encephalopathy in 5 Domestic Cats Veterinary Record 129:233-236, 1991. Pubmed reference: 1957458.
1990 Aldhous, P. :
BSE - Spongiform Encephalopathy Found in Cat Nature 345:194, 1990. Pubmed reference: 2333092. DOI: 10.1038/345194c0.
Leggett, M.M., Dukes, J., Pirie, H.M. :
A Spongiform Encephalopathy in a Cat Veterinary Record 127:586-588, 1990. Pubmed reference: 2075687.
Meldrum, K.C. :
Spongiform Encephalopathy in a Cat Veterinary Record 126:513, 1990. Pubmed reference: 2336781.
Parrysmith, P.W., Isserlin, J.A.M., Auerbach, M., Bellois, E., Loosevelt, R. :
Spongiform Encephalopathy in a Cat Veterinary Record 126:513, 1990.
Wyatt, J.M., Pearson, G.R., Smerdon, T., Gruffydd-Jones, T.J., Wells, G.A.H. :
Spongiform Encephalopathy in a Cat Veterinary Record 126:513, 1990.

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  • Created by Frank Nicholas on 06 Sep 2005