OMIA 000944-9685 : Spongiform encephalopathy in Felis catus

In other species: chicken , white-tufted-ear marmoset , macaques , crab-eating macaque , Rhesus monkey , dog , domestic ferret , puma , horse , pig , Arabian camel , deer , Eurasian elk , Western roe deer , Eastern wapiti , Manchurian Wapiti , reindeer , black-tailed deer , white-tailed deer , , American bison , cattle , goat , , sheep , eland , greater kudu , gemsbok , rabbit , golden hamster , domestic guinea pig , chital , fallow deer , cheetah , blue antelope , Arabian oryx , , scimitar-horned oryx , nyala , water buffalo , , , American mink ,

Possibly relevant human trait(s) and/or gene(s) (MIM number): 176640 (gene)

Mendelian trait/disorder: unknown

Considered a defect: unknown

Cross-species summary: Spongiform encephalopathies are a class of fatal neurological diseases. Clinical signs are characteristic of a progressive degeneration of the central nervous system; they include pruritis, abnormalities of gait and recumbency. Death is inevitable. On post-mortem, brain histopathology shows a characteristic spongy appearance. The infectious agent is a modified form of a protein encoded by a gene in the host. The name given to this infectious particle is prion. The host gene is called the prion protein (PrP) gene, which is a normal part of the genome of mammals and chickens. Its polypeptide product, called cellular PrP(superscript C), is a naturally-occurring protein attached to the outer surface of neurones and some other cells. PrP(superscript C) appears to play a role in maintaining the Purkinje cells of the cerebellum, which are essential for balance and muscular function. The infectious agent, called scrapie PrP(superscript Sc), is a modifed form of PrP(superscript C), where the modifications involve glycosylation and the creation of intra-strand di-sulphide bonds. It is important to realise that these modifications involve no change in amino acid sequence. When PrP(superscript Sc) molecules enter a previously uninfected host, they convert the naturally occurring PrP(superscript C) molecules, produced by the host gene, into infectious PrP(superscript Sc) particles, which ultimately cause clinical signs in that animal, and which can spread to other animals, both horizontally (by infection) and vertically (by maternal transmission).


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Orge, L., Lima, C., Machado, C., Tavares, P., Mendonça, P., Carvalho, P., Silva, J., Pinto, M.L., Bastos, E., Pereira, J.C., Gonçalves-Anjo, N., Gama, A., Esteves, A., Alves, A., Matos, A.C., Seixas, F., Silva, F., Pires, I., Figueira, L., Vieira-Pinto, M., Sargo, R., Pires, M.D.A. :
Neuropathology of animal prion diseases. Biomolecules 11:, 2021. Pubmed reference: 33801117. DOI: 10.3390/biom11030466.
2020 Kim, H.H., Kim, Y.C., Kim, K., Kim, A.D., Jeong, B.H. :
Novel Polymorphisms and Genetic Features of the Prion Protein Gene (<i>PRNP</i>) in Cats, Hosts of Feline Spongiform Encephalopathy. Genes (Basel) 12:, 2020. Pubmed reference: 33374431. DOI: 10.3390/genes12010013.
2015 Aguilar-Calvo, P., García, C., Espinosa, J.C., Andreoletti, O., Torres, J.M. :
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2012 Stewart, P., Campbell, L., Skogtvedt, S., Griffin, K.A., Arnemo, J.M., Tryland, M., Girling, S., Miller, M.W., Tranulis, M.A., Goldmann, W. :
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2005 Kelly, DF., Wells, GA., Haritani, M., Higgins, RJ., Jeffrey, M. :
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2002 Demierre, S., Botteron, C., Cizinauskas, S., Doherr, M.G., Fatzer, R., Jaggy, A. :
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2001 Ryder, S.J., Wells, G.A.H., Bradshaw, J.M., Pearson, G.R. :
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1998 Zanusso, G., Nardelli, E., Rosati, A., Fabrizi, G.M., Ferrari, S., Carteri, A., Desimone, F., Rizutto, N., Monaco, S. :
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1996 Anon. :
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1995 Bratberg, B., Ueland, K., Wells, G.A.H. :
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1994 Fraser, H., Pearson, G.R., McConnell, I., Bruce, M.E., Wyatt, J.M., Gruffydd-Jones, T.J. :
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Hewickertrautwein, M. :
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1993 Wyatt, J.M., Pearson, G.R., Gruffydd-Jones, T.J. :
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1992 Gruffydd-Jones, T.J., Galloway, P.E., Pearson, G.R. :
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Wells, G.A.H., Mcgill, I.S. :
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1991 Pearson, G.R., Gruffydd-Jones, T.J., Wyatt, J.M., Hope, J., Chong, A., Scott, A.C., Dawson, M., Wells, G.A.H. :
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Synge, B.A., Waters, J.W. :
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Wyatt, J.M. :
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1990 Aldhous, P. :
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Leggett, M.M., Dukes, J., Pirie, H.M. :
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Meldrum, K.C. :
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Wyatt, J.M., Pearson, G.R., Smerdon, T., Gruffydd-Jones, T.J., Wells, G.A.H. :
Spongiform Encephalopathy in a Cat Veterinary Record 126:513, 1990.

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  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 15 May 2020