OMIA 000944-9913 : Spongiform encephalopathy, susceptibility/resistance to in Bos taurus

In other species: domestic cat , goat , pig , sheep , American mink , golden hamster , blue antelope , white-tufted-ear marmoset , eland , domestic ferret , greater kudu , Arabian oryx , , puma , Eastern wapiti , cheetah , chicken , crab-eating macaque , Rhesus monkey , macaques , black-tailed deer , , rabbit , dog , water buffalo , , Manchurian Wapiti , deer , domestic guinea pig , , Western roe deer , fallow deer , , , horse , white-tailed deer , chital , American bison , Eurasian elk , nyala , gemsbok , scimitar-horned oryx , reindeer , Arabian camel , red deer , Mallard

Possibly relevant human trait(s) and/or gene(s) (MIM number): 176640 (gene)

Mendelian trait/disorder: unknown

Considered a defect: yes

Year key variant first reported: 2008

Cross-species summary: Spongiform encephalopathies are a class of fatal neurological diseases. Clinical signs are characteristic of a progressive degeneration of the central nervous system; they include pruritis, abnormalities of gait and recumbency. Death is inevitable. On post-mortem, brain histopathology shows a characteristic spongy appearance. The infectious agent is a modified form of a protein encoded by a gene in the host. The name given to this infectious particle is prion. The host gene is called the prion protein (PrP) gene, which is a normal part of the genome of mammals and chickens. Its polypeptide product, called cellular PrP(superscript C), is a naturally-occurring protein attached to the outer surface of neurones and some other cells. PrP(superscript C) appears to play a role in maintaining the Purkinje cells of the cerebellum, which are essential for balance and muscular function. The infectious agent, called scrapie PrP(superscript Sc), is a modifed form of PrP(superscript C), where the modifications involve glycosylation and the creation of intra-strand di-sulphide bonds. It is important to realise that these modifications involve no change in amino acid sequence. When PrP(superscript Sc) molecules enter a previously uninfected host, they convert the naturally occurring PrP(superscript C) molecules, produced by the host gene, into infectious PrP(superscript Sc) particles, which ultimately cause clinical signs in that animal, and which can spread to other animals, both horizontally (by infection) and vertically (by maternal transmission).

Species-specific name: Bovine spongiform encephalopathy; Mad Cow Disease

Species-specific symbol: BSE

Molecular basis: Richt and Hall (2008) "identified a novel mutation in the bovine prion protein gene (Prnp), called E211K, of a confirmed BSE positive cow from Alabama, United States of America. This mutation is identical to the E200K pathogenic mutation found in humans with a genetic form of CJD. This finding represents the first report of a confirmed case of BSE with a potential pathogenic mutation within the bovine Prnp gene. We hypothesize that the bovine Prnp E211K mutation most likely has caused BSE in “the approximately 10-year-old cow” carrying the E221K mutation."

Won et al. (2020) "found a high rate of K211 somatic mutations of the bovine PRNP gene in the medulla oblongata of three Holsteins (10% ± 4.4%, 28% ± 2%, and 19.55% ± 3.1%). In addition, in silico programs showed that the K211 somatic mutation was damaging. To the best of our knowledge, this study is the first to investigate K211 somatic mutations of the bovine PRNP gene that are associated with potential BSE progression."

Prevalence: Heaton et al. (2008): "The K211 allele was not detected in 6062 cattle, including those from five commercial beef processing plants (3892 carcasses) and 2170 registered cattle from 42 breeds. Multiple nearby polymorphisms in Prnp coding sequence of 1456 diverse purebred cattle (42 breeds) did not interfere with scoring E211 or K211 alleles. Based on these results, the upper bounds for prevalence of the E211K variant was estimated to be extremely low, less than 1 in 2000 cattle (Bayesian analysis based on 95% quantile of the posterior distribution with a uniform prior)."

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
PRNP prion protein Bos taurus 13 NC_037340.1 (47039937..47060168) PRNP Homologene, Ensembl, NCBI gene


By default, variants are sorted chronologically by year of publication, to provide a historical perspective. Readers can re-sort on any column by clicking on the column header. Click it again to sort in a descending order. To create a multiple-field sort, hold down Shift while clicking on the second, third etc relevant column headers.

WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.

Breed(s) Variant Phenotype Gene Allele Type of Variant Reference Sequence Chr. g. or m. c. or n. p. Verbal Description EVA ID Inferred EVA rsID Year Published PubMed ID(s) Acknowledgements
Numerous breeds Spongiform encephalopathy (mad cow disease) PRNP missense UMD3.1 13 g.47415059G>A c.631G>A p.(E211K) 2008 18787697 Genomic coordinates obtained from EBI's VEP


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Chong, A., Foster, J.D., Goldmann, W., Gonzalez, L., Jeffrey, M., O'Connor, M.J., Bishop, K., Maddison, B.C., Houston, E.F., Gough, K.C., Hunter, N. :
BSE can propagate in sheep co-infected or pre-infected with scrapie. Sci Rep 11:11931, 2021. Pubmed reference: 34099797. DOI: 10.1038/s41598-021-91397-8.
Kim, Y.C., Park, K.J., Hwang, J.Y., Park, H.C., Kang, H.E., Sohn, H.J., Jeong, B.H. :
In-depth examination of PrP^Sc in Holstein cattle carrying the E211K somatic mutation of the bovine prion protein gene (PRNP). Transbound Emerg Dis :, 2021. Pubmed reference: 34470082. DOI: 10.1111/tbed.14309.
Orge, L., Lima, C., Machado, C., Tavares, P., Mendonça, P., Carvalho, P., Silva, J., Pinto, M.L., Bastos, E., Pereira, J.C., Gonçalves-Anjo, N., Gama, A., Esteves, A., Alves, A., Matos, A.C., Seixas, F., Silva, F., Pires, I., Figueira, L., Vieira-Pinto, M., Sargo, R., Pires, M.D.A. :
Neuropathology of animal prion diseases. Biomolecules 11:, 2021. Pubmed reference: 33801117. DOI: 10.3390/biom11030466.
Singh, P., Ali, S.A. :
Impact of CRISPR-Cas9-based genome engineering in farm animals. Vet Sci 8:, 2021. Pubmed reference: 34209174. DOI: 10.3390/vetsci8070122.
2020 Ayers, J.I., Paras, N.A., Prusiner, S.B. :
Expanding spectrum of prion diseases. Emerg Top Life Sci 4:155-167, 2020. Pubmed reference: 32803268. DOI: 10.1042/ETLS20200037.
Kim, Y.C., Kim, S.K., Won, S.Y., Jeong, B.H. :
Polymorphisms of shadow of prion protein gene (SPRN) in Korean native cattle (Hanwoo) and Holstein cattle. Sci Rep 10:15272, 2020. Pubmed reference: 32943703. DOI: 10.1038/s41598-020-72225-x.
Won, S.Y., Kim, Y.C., Jeong, B.H. :
First Report of the Potential Bovine Spongiform Encephalopathy (BSE)-Related Somatic Mutation E211K of the Prion Protein Gene (<i>PRNP</i>) in Cattle. Int J Mol Sci 21:, 2020. Pubmed reference: 32549191. DOI: 10.3390/ijms21124246.
2019 Hagiwara, K., Sato, Y., Yamakawa, Y., Hara, H., Tobiume, M., Okemoto-Nakamura, Y., Sata, T., Horiuchi, M., Shibata, H., Ono, F. :
Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys. PLoS One 14:e0216807, 2019. Pubmed reference: 31095605. DOI: 10.1371/journal.pone.0216807.
Huor, A., Espinosa, J.C., Vidal, E., Cassard, H., Douet, J.Y., Lugan, S., Aron, N., Marín-Moreno, A., Lorenzo, P., Aguilar-Calvo, P., Badiola, J., Bolea, R., Pumarola, M., Benestad, S.L., Orge, L., Thackray, A.M., Bujdoso, R., Torres, J.M., Andreoletti, O. :
The emergence of classical BSE from atypical/Nor98 scrapie. Proc Natl Acad Sci U S A :, 2019. Pubmed reference: 31843908. DOI: 10.1073/pnas.1915737116.
Kumagai, S., Daikai, T., Onodera, T. :
Bovine Spongiform Encephalopathy 
- A Review from the Perspective of Food Safety. Food Saf (Tokyo) 7:21-47, 2019. Pubmed reference: 31998585. DOI: 10.14252/foodsafetyfscj.2018009.
Langeveld, J.P.M., Pirisinu, L., Jacobs, J.G., Mazza, M., Lantier, I., Simon, S., Andréoletti, O., Acin, C., Esposito, E., Fast, C., Groschup, M., Goldmann, W., Spiropoulos, J., Sklaviadis, T., Lantier, F., Ekateriniadou, L., Papasavva-Stylianou, P., van Keulen, L.J.M., Acutis, P.L., Agrimi, U., Bossers, A., Nonno, R. :
Four types of scrapie in goats differentiated from each other and bovine spongiform encephalopathy by biochemical methods. Vet Res 50:97, 2019. Pubmed reference: 31767033. DOI: 10.1186/s13567-019-0718-z.
2018 Gielbert, A., Thorne, J.K., Plater, J.M., Thorne, L., Griffiths, P.C., Simmons, M.M., Cassar, C.A. :
Molecular characterisation of atypical BSE prions by mass spectrometry and changes following transmission to sheep and transgenic mouse models. PLoS One 13:e0206505, 2018. Pubmed reference: 30408075. DOI: 10.1371/journal.pone.0206505.
Houston, F., Andréoletti, O. :
Animal prion diseases: the risks to human health. Brain Pathol 29:248-262, 2018. Pubmed reference: 30588682. DOI: 10.1111/bpa.12696.
2017 Kim, Y.C., Jeong, B.H. :
Lack of germline mutation at codon 211 of the prion protein gene (PRNP) in Korean native cattle - Short communication. Acta Vet Hung 65:147-152, 2017. Pubmed reference: 28244340. DOI: 10.1556/004.2017.015.
Peggion, C., Bertoli, A., Sorgato, M.C. :
Almost a century of prion protein(s): From pathology to physiology, and back to pathology. Biochem Biophys Res Commun 483:1148-1155, 2017. Pubmed reference: 27581199. DOI: 10.1016/j.bbrc.2016.07.118.
Serra, F., Müller, J., Gray, J., Lüthi, R., Dudas, S., Czub, S., Seuberlich, T. :
PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrP(sc). Brain Res 1659:19-28, 2017. Pubmed reference: 28119056. DOI: 10.1016/j.brainres.2017.01.015.
Simmons, M., Ru, G., Casalone, C., Iulini, B., Cassar, C., Seuberlich, T. :
Discontools: Identifying gaps in controlling bovine spongiform encephalopathy. Transbound Emerg Dis :, 2017. Pubmed reference: 28795509. DOI: 10.1111/tbed.12671.
Vázquez-Fernández, E., Young, H.S., Requena, J.R., Wille, H. :
The Structure of Mammalian Prions and Their Aggregates. Int Rev Cell Mol Biol 329:277-301, 2017. Pubmed reference: 28109330. DOI: 10.1016/bs.ircmb.2016.08.013.
Vrentas, C.E., Greenlee, J.J., Foster, G.H., West, J., Jahnke, M.M., Schmidt, M.T., Nicholson, E.M. :
Effects of a naturally occurring amino acid substitution in bovine PrP: a model for inherited prion disease in a natural host species. BMC Res Notes 10:759, 2017. Pubmed reference: 29262866. DOI: 10.1186/s13104-017-3085-8.
2016 Bevacqua, R.J., Fernandez-Martín, R., Savy, V., Canel, N.G., Gismondi, M.I., Kues, W.A., Carlson, D.F., Fahrenkrug, S.C., Niemann, H., Taboga, O.A., Ferraris, S., Salamone, D.F. :
Efficient edition of the bovine PRNP prion gene in somatic cells and IVF embryos using the CRISPR/Cas9 system. Theriogenology 86:1886-1896.e1, 2016. Pubmed reference: 27566851. DOI: 10.1016/j.theriogenology.2016.06.010.
Brunelle, B.W., O'Grady, A.M., Nicholson, E.M., Seabury, C.M. :
Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle. PLoS One 11:e0155924, 2016. Pubmed reference: 27224046. DOI: 10.1371/journal.pone.0155924.
Davenport, K.A., Henderson, D.M., Mathiason, C.K., Hoover, E.A. :
Assessment of the PrPc amino-terminal domain in prion species barriers. J Virol :, 2016. Pubmed reference: 27654299. DOI: 10.1128/JVI.01121-16.
Hedman, C., Bolea, R., Marín, B., Cobrière, F., Filali, H., Vazquez, F., Pitarch, J.L., Vargas, A., Acín, C., Moreno, B., Pumarola, M., Andreoletti, O., Badiola, J.J. :
Transmission of sheep-bovine spongiform encephalopathy to pigs. Vet Res 47:14, 2016. Pubmed reference: 26742788. DOI: 10.1186/s13567-015-0295-8.
Jaumain, E., Quadrio, I., Herzog, L., Reine, F., Rezaei, H., Andréoletti, O., Laude, H., Perret-Liaudet, A., Haïk, S., Béringue, V. :
Absence of evidence for a causal link between L-BSE and known forms of sporadic CJD in human PrP transgenic mice. J Virol :, 2016. Pubmed reference: 27681129. DOI: 10.1128/JVI.01383-16.
Moore, S.J., West Greenlee, M.H., Smith, J.D., Vrentas, C.E., Nicholson, E.M., Greenlee, J.J. :
A Comparison of Classical and H-Type Bovine Spongiform Encephalopathy Associated with E211K Prion Protein Polymorphism in Wild-Type and EK211 Cattle Following Intracranial Inoculation. Front Vet Sci 3:78, 2016. Pubmed reference: 27695695. DOI: 10.3389/fvets.2016.00078.
Xerxa, E., Barbisin, M., Chieppa, M.N., Krmac, H., Vallino Costassa, E., Vatta, P., Simmons, M., Caramelli, M., Casalone, C., Corona, C., Legname, G. :
Whole Blood Gene Expression Profiling in Preclinical and Clinical Cattle Infected with Atypical Bovine Spongiform Encephalopathy. PLoS One 11:e0153425, 2016. Pubmed reference: 27073865. DOI: 10.1371/journal.pone.0153425.
Yang, Q., Zhang, S., Liu, L., Cao, X., Lei, C., Qi, X., Lin, F., Qu, W., Qi, X., Liu, J., Wang, R., Chen, H., Lan, X. :
Application of mathematical expectation (ME) strategy for detecting low frequency mutations: An example for evaluating 14-bp insertion/deletion (indel) within the bovine PRNP gene. Prion :0, 2016. Pubmed reference: 27580010. DOI: 10.1080/19336896.2016.1211593.
2015 Aguilar-Calvo, P., García, C., Espinosa, J.C., Andreoletti, O., Torres, J.M. :
Prion and prion-like diseases in animals. Virus Res 207:82-93, 2015. Pubmed reference: 25444937. DOI: 10.1016/j.virusres.2014.11.026.
Budka, H., Will, R.G. :
The end of the BSE saga: do we still need surveillance for human prion diseases? Swiss Med Wkly 145:w14212, 2015. Pubmed reference: 26715203. DOI: 10.4414/smw.2015.14212.
Choi, W., Kim, E., Yum, S.Y., Lee, C., Lee, J., Moon, J., Ramachandra, S., Malaweera, B.O., Cho, J., Kim, J.S., Kim, S., Jang, G. :
Efficient PRNP deletion in bovine genome using gene-editing technologies in bovine cells. Prion 9:278-91, 2015. Pubmed reference: 26217959. DOI: 10.1080/19336896.2015.1071459.
Dudas, S., James, J., Anderson, R., Czub, S. :
Exploring the cause of initially reactive bovine brains on rapid tests for BSE. Prion 9:429-43, 2015. Pubmed reference: 26689488. DOI: 10.1080/19336896.2015.1115945.
Greenlee, J.J., Greenlee, M.H. :
The transmissible spongiform encephalopathies of livestock. ILAR J 56:7-25, 2015. Pubmed reference: 25991695. DOI: 10.1093/ilar/ilv008.
Quimby, A.E., Shamy, M.C. :
The Canadian Management of Bovine Spongiform Encephalopathy in Historical and Scientific Perspective, 1990-2014. Can J Neurol Sci 42:472-81, 2015. Pubmed reference: 26357946. DOI: 10.1017/cjn.2015.286.
Zhao, H., Du, Y., Chen, S., Qing, L., Wang, X., Huang, J., Wu, D., Zhang, Y. :
The prion protein gene polymorphisms associated with bovine spongiform encephalopathy susceptibility differ significantly between cattle and buffalo. Infect Genet Evol 36:531-8, 2015. Pubmed reference: 26319996. DOI: 10.1016/j.meegid.2015.08.031.
2014 Barria, M.A., Ironside, J.W., Head, M.W. :
Exploring the zoonotic potential of animal prion diseases: In vivo and in vitro approaches. Prion 8:, 2014. Pubmed reference: 24549113.
Vernerova, K., Tothova, L., Mikova, A., Vodrazka, P., Simek, B., Hanusova, L., Citek, J. :
BSE-associated polymorphisms in the prion protein gene: an investigation. J Anim Breed Genet 131:403-8, 2014. Pubmed reference: 24720684. DOI: 10.1111/jbg.12090.
2013 Acquatella-Tran Van Ba, I., Imberdis, T., Perrier, V. :
From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases. Int J Cell Biol 2013:975832, 2013. Pubmed reference: 24222767. DOI: 10.1155/2013/975832.
Hueston, W.D. :
BSE and variant CJD: emerging science, public pressure and the vagaries of policy-making. Prev Vet Med 109:179-84, 2013. Pubmed reference: 23287715. DOI: 10.1016/j.prevetmed.2012.11.023.
Kretzschmar, H., Tatzelt, J. :
Prion disease: a tale of folds and strains. Brain Pathol 23:321-32, 2013. Pubmed reference: 23587138. DOI: 10.1111/bpa.12045.
Lee, J., Kim, S.Y., Hwang, K.J., Ju, Y.R., Woo, H.J. :
Prion Diseases as Transmissible Zoonotic Diseases. Osong Public Health Res Perspect 4:57-66, 2013. Pubmed reference: 24159531. DOI: 10.1016/j.phrp.2012.12.008.
Lloyd, S.E., Mead, S., Collinge, J. :
Genetics of prion diseases. Curr Opin Genet Dev 23:345-51, 2013. Pubmed reference: 23518043. DOI: 10.1016/j.gde.2013.02.012.
Vidal, E., Fernández-Borges, N., Pintado, B., Ordóñez, M., Márquez, M., Fondevila, D., Eraña, H., Torres, J.M., Pumarola, M., Castilla, J. :
Exploring the risks of a putative transmission of BSE to new species. Prion 7:, 2013. Pubmed reference: 24184875.
2012 Choi, S., Woo, H.J., Lee, J. :
Sequence variations of the bovine prion protein gene (PRNP) in native Korean Hanwoo cattle. J Vet Sci 13:127-37, 2012. Pubmed reference: 22705734.
Guldimann, C., Gsponer, M., Drögemüller, C., Oevermann, A., Seuberlich, T. :
Atypical H-type bovine spongiform encephalopathy in a cow born after the reinforced feed ban on meat-and-bone meal in Europe. J Clin Microbiol 50:4171-4, 2012. Pubmed reference: 23035195. DOI: 10.1128/JCM.02178-12.
Gurgul, A., Czarnik, U., Urszula, C., Larska, M., Polak, M.P., Strychalski, J., Słota, E. :
Polymorphism of the prion protein gene (PRNP) in Polish cattle affected by classical bovine spongiform encephalopathy. Mol Biol Rep 39:5211-7, 2012. Pubmed reference: 22170597. DOI: 10.1007/s11033-011-1318-9.
Gurgul, A., Polak, M.P., Larska, M., Słota, E. :
PRNP and SPRN genes polymorphism in atypical bovine spongiform encephalopathy cases diagnosed in Polish cattle. J Appl Genet 53:337-42, 2012. Pubmed reference: 22723200. DOI: 10.1007/s13353-012-0102-4.
Imran, M., Mahmood, S., Babar, M.E., Hussain, R., Yousaf, M.Z., Abid, N.B., Lone, K.P. :
PRNP gene variation in Pakistani cattle and buffaloes. Gene 505:180-5, 2012. Pubmed reference: 22634099. DOI: 10.1016/j.gene.2012.05.038.
Jeong, B.H., Jin, H.T., Carp, R.I., Kim, Y.S. :
Bovine spongiform encephalopathy (BSE)-associated polymorphisms of the prion protein (PRNP) gene in Korean native cattle. Anim Genet :, 2012. Pubmed reference: 23134411. DOI: 10.1111/age.12004.
Seuberlich, T., Gsponer, M., Drögemüller, C., Polak, M.P., McCutcheon, S., Heim, D., Oevermann, A., Zurbriggen, A. :
Novel prion protein in BSE-affected cattle, Switzerland. Emerg Infect Dis 18:158-9, 2012. Pubmed reference: 22261120. DOI: 10.3201/eid1801.111225.
Thomson, J.M., Bowles, V., Choi, J.W., Basu, U., Meng, Y., Stothard, P., Moore, S. :
The identification of candidate genes and SNP markers for classical bovine spongiform encephalopathy susceptibility. Prion 6:461-9, 2012. Pubmed reference: 22918267. DOI: 10.4161/pri.21866.
Windl, O., Dawson, M. :
Animal prion diseases. Subcell Biochem 65:497-516, 2012. Pubmed reference: 23225014. DOI: 10.1007/978-94-007-5416-4_18.
2011 Czarnik, U., Strychalski, J., Zabolewicz, T., Pareek, C.S. :
Populationwide investigation of two indel polymorphisms at the prion protein gene in Polish Holstein-Friesian cattle. Biochem Genet 49:303-12, 2011. Pubmed reference: 21221760. DOI: 10.1007/s10528-010-9408-2.
Hamir, A.N., Kehrli, M.E., Kunkle, R.A., Greenlee, J.J., Nicholson, E.M., Richt, J.A., Miller, J.M., Cutlip, R.C. :
Experimental interspecies transmission studies of the transmissible spongiform encephalopathies to cattle: comparison to bovine spongiform encephalopathy in cattle. J Vet Diagn Invest 23:407-20, 2011. Pubmed reference: 21908269. DOI: 10.1177/1040638711403404.
Lloyd, S., Mead, S., Collinge, J. :
Genetics of prion disease. Top Curr Chem 305:1-22, 2011. Pubmed reference: 21528440. DOI: 10.1007/128_2011_157.
Matthews, D., Adkin, A. :
Bovine spongiform encephalopathy: is it time to relax BSE-related measures in the context of international trade? Rev Sci Tech 30:107-17, 2011. Pubmed reference: 21809757.
Msalya, G., Shimogiri, T., Ohno, S., Okamoto, S., Kawabe, K., Minezawa, M., Maeda, Y. :
Evaluation of PRNP expression based on genotypes and alleles of two indel loci in the medulla oblongata of Japanese Black and Japanese Brown cattle. PLoS One 6:e18787, 2011. Pubmed reference: 21611160. DOI: 10.1371/journal.pone.0018787.
Qin, L.H., Zhao, Y.M., Bao, Y.H., Bai, W.L., Chong, J., Zhang, G.L., Zhang, J.B., Zhao, Z.H. :
Polymorphism of the prion protein gene (PRNP) in two Chinese indigenous cattle breeds. Mol Biol Rep 38:4197-204, 2011. Pubmed reference: 21120616. DOI: 10.1007/s11033-010-0541-0.
Yoshikawa, Y., Horiuchi, M., Ishiguro, N., Kadohira, M., Kai, S., Mizusawa, H., Nagata, C., Onodera, T., Sata, T., Tsutsui, T., Yamada, M., Yamamoto, S. :
Alternative BSE Risk Assessment Methodology of Imported Beef and Beef Offal to Japan. J Vet Med Sci :, 2011. Pubmed reference: 22083084.
2010 Adkin, A., Webster, V., Arnold, ME., Wells, GA., Matthews, D. :
Estimating the impact on the food chain of changing bovine spongiform encephalopathy (BSE) control measures: the BSE control model. Prev Vet Med 93:170-82, 2010. Pubmed reference: 19836847. DOI: 10.1016/j.prevetmed.2009.09.018.
Morina, R., Knorr, C., Haase, B., Leeb, T., Seuberlich, T., Zurbriggen, A., Brem, G., Schutz, E., Brenig, B. :
Molecular analysis of carbohydrate N-acetylgalactosamine 4-O sulfotransferase 8 (CHST8) as a candidate gene for bovine spongiform encephalopathy susceptibility. Anim Genet 41:85-8, 2010. Pubmed reference: 19744145. DOI: 10.1111/j.1365-2052.2009.01951.x.
Msalya, G., Shimogiri, T., Nishitani, K., Okamoto, S., Kawabe, K., Minesawa, M., Maeda, Y. :
Indels within promoter and intron 1 of bovine prion protein gene modulate the gene expression levels in the medulla oblongata of two Japanese cattle breeds. Anim Genet 41:218-21, 2010. Pubmed reference: 19917050. DOI: 10.1111/j.1365-2052.2009.01983.x.
Murdoch, BM., Clawson, ML., Laegreid, WW., Stothard, P., Settles, M., McKay, S., Prasad, A., Wang, Z., Moore, SS., Williams, JL. :
A 2cM genome-wide scan of European Holstein cattle affected by classical BSE. BMC Genet 11:20, 2010. Pubmed reference: 20350325. DOI: 10.1186/1471-2156-11-20.
Shimogiri, T., Msalya, G., Myint, SL., Okamoto, S., Kawabe, K., Tanaka, K., Mannen, H., Minezawa, M., Namikawa, T., Amano, T., Yamamoto, Y., Maeda, Y. :
Allele Distributions and Frequencies of the Six Prion Protein Gene (PRNP) Polymorphisms in Asian Native Cattle, Japanese Breeds, and Mythun (Bos frontalis). Biochem Genet :, 2010. Pubmed reference: 20623331. DOI: 10.1007/s10528-010-9364-x.
Zhao, H., Wang, XY., Zou, W., Zhang, YP. :
Prion protein gene (PRNP) polymorphisms in native Chinese cattle. Genome 53:138-45, 2010. Pubmed reference: 20140032. DOI: 10.1139/g09-087.
2009 Ferguson-Smith, MA., Richt, JA. :
Rare BSE mutation raises concerns over risks to public health. Nature 457:1079, 2009. Pubmed reference: 19242452. DOI: 10.1038/4571079b.
Harman, JL., Silva, CJ. :
Bovine spongiform encephalopathy. J Am Vet Med Assoc 234:59-72, 2009. Pubmed reference: 19119967. DOI: 10.2460/javma.234.1.59.
Lefrère, J.J., Hewitt, P. :
From mad cows to sensible blood transfusion: the risk of prion transmission by labile blood components in the United Kingdom and in France. Transfusion 49:797-812, 2009. Pubmed reference: 19170997. DOI: 10.1111/j.1537-2995.2008.02044.x.
Nau, JY. :
[Remember "la vache folle" (spongiform encephalopathy)] Rev Med Suisse 5:1740, 2009. Pubmed reference: 19803229.
Nomura, S., Miyasho, T., Maeda, N., Doh-Ura, K., Yokota, H. :
Autoantibody to glial fibrillary acidic protein in the sera of cattle with bovine spongiform encephalopathy. Proteomics 9:4029-35, 2009. Pubmed reference: 19658106. DOI: 10.1002/pmic.200900066.
Tang, Y., Xiang, W., Hawkins, SA., Kretzschmar, HA., Windl, O. :
Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity. J Virol 83:9464-73, 2009. Pubmed reference: 19587050. DOI: 10.1128/JVI.00352-09.
Tester, S., Juillerat, V., Doherr, MG., Haase, B., Polak, M., Ehrensperger, F., Leeb, T., Zurbriggen, A., Seuberlich, T. :
Biochemical typing of pathological prion protein in aging cattle with BSE. Virol J 6:64, 2009. Pubmed reference: 19470160. DOI: 10.1186/1743-422X-6-64.
2008 Brunelle, BW., Greenlee, JJ., Seabury, CM., Brown, CE., Nicholson, EM. :
Frequencies of polymorphisms associated with BSE resistance differ significantly between Bos taurus, Bos indicus, and composite cattle. BMC Vet Res 4:36, 2008. Pubmed reference: 18808703. DOI: 10.1186/1746-6148-4-36.
Ducrot, C., Arnold, M., de Koeijer, A., Heim, D., Calavas, D. :
Review on the epidemiology and dynamics of BSE epidemics. Vet Res 39:15, 2008. Pubmed reference: 18187031. DOI: 10.1051/vetres:2007053.
Heaton, M.P., Keele, J.W., Harhay, G.P., Richt, J.A., Koohmaraie, M., Wheeler, T.L., Shackelford, S.D., Casas, E., King, D.A., Sonstegard, T.S., Van Tassell, C.P., Neibergs, H.L., Chase, C.C., Kalbfleisch, T.S., Smith, T.P., Clawson, M.L., Laegreid, W.W. :
Prevalence of the prion protein gene E211K variant in U.S. cattle. BMC Vet Res 4:25, 2008. Pubmed reference: 18625065. DOI: 10.1186/1746-6148-4-25.
Juling, K., Schwarzenbacher, H., Frankenberg, U., Ziegler, U., Groschup, M., Williams, JL., Fries, R. :
Characterization of a 320-kb region containing the HEXA gene on bovine chromosome 10 and analysis of its association with BSE susceptibility. Anim Genet 39:400-6, 2008. Pubmed reference: 18513278. DOI: 10.1111/j.1365-2052.2008.01743.x.
Nicholson, EM., Brunelle, BW., Richt, JA., Kehrli, ME., Greenlee, JJ. :
Identification of a heritable polymorphism in bovine PRNP associated with genetic transmissible spongiform encephalopathy: evidence of heritable BSE. PLoS ONE 3:e2912, 2008. Pubmed reference: 18698343. DOI: 10.1371/journal.pone.0002912.
Panza, G., Stöhr, J., Dumpitak, C., Papathanassiou, D., Weiss, J., Riesner, D., Willbold, D., Birkmann, E. :
Spontaneous and BSE-prion-seeded amyloid formation of full length recombinant bovine prion protein. Biochem Biophys Res Commun 373:493-7, 2008. Pubmed reference: 18585368. DOI: 10.1016/j.bbrc.2008.06.059.
Richt, JA., Hall, SM. :
BSE case associated with prion protein gene mutation. PLoS Pathog 4:e1000156, 2008. Pubmed reference: 18787697. DOI: 10.1371/journal.ppat.1000156.
Sejvar, JJ., Schonberger, LB., Belay, ED. :
Transmissible spongiform encephalopathies. J Am Vet Med Assoc 233:1705-12, 2008. Pubmed reference: 19046027. DOI: 10.2460/javma.233.11.1705.
Simmons, MM., Spiropoulos, J., Hawkins, SA., Bellworthy, SJ., Tongue, SC. :
Approaches to investigating transmission of spongiform encephalopathies in domestic animals using BSE as an example. Vet Res 39:34, 2008. Pubmed reference: 18284911. DOI: 10.1051/vetres:2008011.
van Keulen, LJ., Bossers, A., van Zijderveld, F. :
TSE pathogenesis in cattle and sheep. Vet Res 39:24, 2008. Pubmed reference: 18258167. DOI: 10.1051/vetres:2007061.
Vidal, E., Marquez, M., Raeber, AJ., Meissner, K., Oesch, B., Pumarola, M. :
Applicability of a rapid chromatographic immunoassay for analysis of the distribution of PrPBSE in confirmed BSE cases. Vet J 177:448-51, 2008. Pubmed reference: 17689993. DOI: 10.1016/j.tvjl.2007.05.026.
Yoshikawa, Y. :
Epidemiological study on BSE outbreak in Japan. J Vet Med Sci 70:325-36, 2008. Pubmed reference: 18460825.
2007 Crozet, C., Lehmann, S. :
[Prions: where do we stand 20 years after the appearance of bovine spongiform encephalopathy?] Med Sci (Paris) 23:1148-57, 2007. Pubmed reference: 18154718. DOI: 10.1051/medsci/200723121148.
Czarnik, U., Zabolewicz, T., Strychalski, J., Grzybowski, G., Bogusz, M., Walawski, K. :
Deletion/insertion polymorphism of the prion protein gene (PRNP) in Polish Holstein-Friesian cattle. J Appl Genet 48:67-9, 2007. Pubmed reference: 17272863. DOI: 10.1007/BF03194659.
Gurgul, A., Słota, E. :
Effect of bovine PRNP gene polymorphisms on BSE susceptibility in cattle. Folia Biol (Krakow) 55:81-6, 2007. Pubmed reference: 18274249.
Haase, B., Doherr, M.G., Seuberlich, T., Drögemüller, C., Dolf, G., Nicken, P., Schiebel, K., Ziegler, U., Groschup, M.H., Zurbriggen, A., Leeb, T. :
PRNP promoter polymorphisms are associated with BSE susceptibility in Swiss and German cattle. BMC Genet 8:15, 2007. Pubmed reference: 17437640. DOI: 10.1186/1471-2156-8-15.
Morris, C.A. :
A review of genetic resistance to disease in Bos taurus cattle. Vet J 174:481-91, 2007. Pubmed reference: 17095270. DOI: 10.1016/j.tvjl.2006.09.006.
Saunders, G.C., Griffiths, P.C., Cawthraw, S., Tout, A.C., Wiener, P., Woolliams, J.A., Williams, J.L., Windl, O. :
Polymorphisms of the prion protein gene coding region in born-after-the-reinforced-ban (BARB) bovine spongiform encephalopathy cattle in Great Britain. J Gen Virol 88:1374-8, 2007. Pubmed reference: 17374784. DOI: 10.1099/vir.0.82507-0.
2006 Doherr, MG. :
Brief review on the epidemiology of transmissible spongiform encephalopathies (TSE). Vaccine :, 2006. Pubmed reference: 17126962. DOI: 10.1016/j.vaccine.2006.10.059.
Juling, K., Schwarzenbacher, H., Williams, JL., Fries, R. :
A major genetic component of BSE susceptibility. BMC Biol 4:33, 2006. Pubmed reference: 17014722. DOI: 10.1186/1741-7007-4-33.
Pennington, H. :
Origin of bovine spongiform encephalopathy. Lancet 367:298; author reply 298-9, 2006. Pubmed reference: 16139661. DOI: 10.1016/S0140-6736(05)67218-2.
2005 Abrial, D., Calavas, D., Jarrige, N., Ducrot, C. :
Spatial heterogeneity of the risk of BSE in France following the ban of meat and bone meal in cattle feed. Prev Vet Med 67:69-82, 2005.
Abrial, D., Calavas, D., Jarrige, N., Ducrot, C. :
Spatial heterogeneity of the risk of BSE in France following the ban of meat and bone meal in cattle feed. Prev Vet Med 67:69-82, 2005. Pubmed reference: 15698909. DOI: 10.1016/j.prevetmed.2004.10.004.
Abrial, D., Calavas, D., Jarrige, N., Ducrot, C. :
Poultry, pig and the risk of BSE following the feed ban in France--a spatial analysis. Vet Res 36:615-28, 2005. Pubmed reference: 15955285. DOI: 10.1051/vetres:2005020.
Balbus, N., Humeny, A., Kashkevich, K., Henz, I., Fischer, C., Becker, CM., Schiebel, K. :
DNA polymorphisms of the prion doppel gene region in four different German cattle breeds and cows tested positive for bovine spongiform encephalopathy. Mamm Genome 16:884-92, 2005. Pubmed reference: 16284804. DOI: 10.1007/s00335-005-0052-9.
Baron, T., Calavas, D. :
[Bovine spongiform encephalopathy] Pathol Biol (Paris) 53:229-36, 2005. Pubmed reference: 15850957. DOI: 10.1016/j.patbio.2004.09.009.
Buschmann, A., Groschup, MH. :
Highly bovine spongiform encephalopathy-sensitive transgenic mice confirm the essential restriction of infectivity to the nervous system in clinically diseased cattle. J Infect Dis 192:934-42, 2005. Pubmed reference: 16088845. DOI: 10.1086/431602.
Campbell, PN. :
Bovine spongiform encephalopathy--some surprises for biochemists. IUBMB Life 57:273-6, 2005. Pubmed reference: 16036610. DOI: 10.1080/15216540500097152.
Castilla, J., Brun, A., Diaz-San Segundo, F., Salguero, FJ., Gutierrez-Adan, A., Pintado, B., Ramirez, MA., del Riego, L., Torres, JM. :
Vertical transmission of bovine spongiform encephalopathy prions evaluated in a transgenic mouse model. J Virol 79:8665-8, 2005. Pubmed reference: 15956610. DOI: 10.1128/JVI.79.13.8665-8668.2005.
Castilla, J., Gutiérrez-Adán, A., Brun, A., Pintado, B., Salguero, F.J., Parra, B., Segundo, F.D., Ramírez, M.A., Rábano, A., Cano, M.J., Torres, J.M. :
Transgenic mice expressing bovine PrP with a four extra repeat octapeptide insert mutation show a spontaneous, non-transmissible, neurodegenerative disease and an expedited course of BSE infection. FEBS Lett 579:6237-46, 2005. Pubmed reference: 16253245. DOI: 10.1016/j.febslet.2005.09.099.
Colchester, AC., Colchester, NT. :
The origin of bovine spongiform encephalopathy: the human prion disease hypothesis. Lancet 366:856-61, 2005. Pubmed reference: 16139641. DOI: 10.1016/S0140-6736(05)67193-0.
Ducrot, C., Abrial, D., Calavas, D., Carpenter, T. :
A spatio-temporal analysis of BSE cases born before and after the reinforced feed ban in France. Vet Res 36:839-53, 2005. Pubmed reference: 16120257. DOI: 10.1051/vetres:2005037.
Ebringer, A., Rashid, T., Wilson, C. :
Bovine spongiform encephalopathy, multiple sclerosis, and creutzfeldt-jakob disease are probably autoimmune diseases evoked by Acinetobacter bacteria. Ann N Y Acad Sci 1050:417-28, 2005. Pubmed reference: 16014559. DOI: 10.1196/annals.1313.093.
Gibbens, N. :
Surveillance for BSE. Vet Rec 156:718, 2005. Pubmed reference: 15923559.
Gibbens, N. :
Link between feed bins and BSE cases born after July 1996. Vet Rec 157:782-3, 2005. Pubmed reference: 16339984.
Grobben, AH., Steele, PJ., Somerville, RA., Taylor, DM., Schreuder, BE. :
Inactivation of the BSE agent by the heat and pressure process for manufacturing gelatine. Vet Rec 157:277-81, 2005. Pubmed reference: 16157568.
Head, M.W., Ironside, J.W. :
Mad cows and monkey business: the end of vCJD? Lancet 365:730-1, 2005. Pubmed reference: 15733699. DOI: 10.1016/S0140-6736(05)17997-5.
Hejazi, R., Danyluk, AJ. :
Brainstem removal using compressed air for subsequent bovine spongiform encephalopathy testing. Can Vet J 46:436-7, 2005. Pubmed reference: 16018564.
Jeong, BH., Sohn, HJ., Lee, JO., Kim, NH., Kim, JI., Lee, SY., Cho, IS., Joo, YS., Carp, RI., Kim, YS. :
Polymorphisms of the prion protein gene (PRNP) in Hanwoo (Bos taurus coreanae) and Holstein cattle. Genes Genet Syst 80:303-8, 2005. Pubmed reference: 16284424.
Kim, TY., Kim, YS., Kim, JK., Shon, HJ., Lee, YH., Kang, CB., Park, JS., Kang, KS., Lee, YS. :
Risk analysis of Bovine Spongiform Encephalopathy in Korea. J Vet Med Sci 67:743-52, 2005. Pubmed reference: 16141660.
O'Rourke, K. :
The Canada debate. USDA sends team to Canada to investigate BSE situation. J Am Vet Med Assoc 226:504-5, 2005. Pubmed reference: 15742683.
Paisley, LG., Hostrup-Pedersen, J. :
A quantitative assessment of the BSE risk associated with fly ash and slag from the incineration of meat-and-bone meal in a gas-fired power plant in Denmark. Prev Vet Med 68:263-75, 2005. Pubmed reference: 15820119. DOI: 10.1016/j.prevetmed.2005.01.010.
Polak, MP., Zmudzinski, JF. :
Bovine spongiform encephalopathy in Poland. Vet Rec 157:56-8, 2005. Pubmed reference: 16006643.
Roma, AA., Prayson, RA. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: how safe is eating beef? Cleve Clin J Med 72:185-6, 189-90, 192-4, 2005. Pubmed reference: 15825799.
Sander, P., Hamann, H., Drögemüller, C., Kashkevich, K., Schiebel, K., Leeb, T. :
Bovine prion protein gene (PRNP) promoter polymorphisms modulate PRNP expression and may be responsible for differences in bovine spongiform encephalopathy susceptibility. J Biol Chem 280:37408-14, 2005. Pubmed reference: 16141216. DOI: 10.1074/jbc.M506361200.
Scheier, LM. :
The safety of beef in the United States. J Am Diet Assoc 105:339-40, 2005. Pubmed reference: 15746815. DOI: 10.1016/j.jada.2005.01.014.
Schutz, E., Urnovitz, HB., Lakoubov, L., Schulz-Schaeffer, W., Wemheuer, W., Brenig, B. :
Bov-tA short interspersed nucleotide element sequences in circulating nucleic acids from sera of cattle with bovine spongiform encephalopathy (BSE) and sera of cattle exposed to BSE. Clin Diagn Lab Immunol 12:814-20, 2005. Pubmed reference: 16002628. DOI: 10.1128/CDLI.12.7.814-820.2005.
Scicchitano, L. :
Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: background and implications for nursing practice. Insight 29:17, 19-21, 2005. Pubmed reference: 15693468.
Setbon, M., Raude, J., Fischler, C., Flahault, A. :
Risk perception of the "mad cow disease" in france: determinants and consequences. Risk Anal 25:813-26, 2005. Pubmed reference: 16268931. DOI: 10.1111/j.1539-6924.2005.00634.x.
Sheridan, HA., Mcgrath, G., White, P., Fallon, R., Shoukri, MM., Martin, SW. :
A temporal-spatial analysis of bovine spongiform encephalopathy in Irish cattle herds, from 1996 to 2000. Can J Vet Res 69:19-25, 2005. Pubmed reference: 15745218.
Sniehotta, FF., Luszczynska, A., Scholz, U., Hoffmann, KP., Lippke, S., Epplen, JT. :
Discontinuity patterns in stages of the precaution adoption process model: meat consumption during a livestock epidemic. Br J Health Psychol 10:221-35, 2005. Pubmed reference: 15969851. DOI: 10.1348/135910705X26137.
Stevenson, MA., Morris, RS., Lawson, AB., Wilesmith, JW., Ryan, JB., Jackson, R. :
Area-level risks for BSE in British cattle before and after the July 1988 meat and bone meal feed ban. Prev Vet Med 69:129-44, 2005. Pubmed reference: 15899301. DOI: 10.1016/j.prevetmed.2005.01.016.
Sun, G., Guo, M., Shen, A., Mei, F., Peng, X., Gong, R., Guo, D., Wu, J., Tien, P., Xiao, G. :
Bovine PrPC directly interacts with alphaB-crystalline. FEBS Lett 579:5419-24, 2005. Pubmed reference: 16198347. DOI: 10.1016/j.febslet.2005.08.065.
Taylor, JD. :
What practitioners should know about bovine spongiform encephalopathy to serve clients and the cattle industry. J Am Vet Med Assoc 227:1070-8, 2005. Pubmed reference: 16220665.
Wear, A., Henderson, K., Webster, K., Patel, I. :
A comparison of rapid bovine spongiform encephalopathy testing methods on autolyzed bovine brain tissue. J Vet Diagn Invest 17:99-102, 2005. Pubmed reference: 15825488.
2004 Arnold, ME., Wilesmith, JW. :
Estimation of the age-dependent risk of infection to BSE of dairy cattle in Great Britain. Prev Vet Med 66:35-47, 2004. Pubmed reference: 15579333. DOI: 10.1016/j.prevetmed.2004.07.007.
Bailly, Y., Haeberlé, A.M., Blanquet-Grossard, F., Chasserot-Golaz, S., Grant, N., Schulze, T., Bombarde, G., Grassi, J., Cesbron, J.Y., Lemaire-Vieille, C. :
Prion protein (PrPc) immunocytochemistry and expression of the green fluorescent protein reporter gene under control of the bovine PrP gene promoter in the mouse brain. J Comp Neurol 473:244-69, 2004. Pubmed reference: 15101092. DOI: 10.1002/cne.20117.
Biacabe, AG., Laplanche, JL., Ryder, S., Baron, T. :
Distinct molecular phenotypes in bovine prion diseases. EMBO Rep 5:110-5, 2004. Pubmed reference: 14710195. DOI: 10.1038/sj.embor.7400054.
Biverståhl, H., Andersson, A., Gräslund, A., Mäler, L. :
NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein. Biochemistry 43:14940-7, 2004. Pubmed reference: 15554701. DOI: 10.1021/bi0485070.
Braun, U., Gerspach, C., Ryhner, T., Hauri, S. :
Pacing as a clinical sign in cattle with bovine spongiform encephalopathy. Vet Rec 155:420-2, 2004. Pubmed reference: 15508842.
Brink, S., Shute, N. :
Is it safe? New beef rules aim to stop mad cow disease. But they may not be enough--and there's too much we don't know. US News World Rep 136:16-21, 2004. Pubmed reference: 16116714.
Cohen-Sabas, C.H., Heim, D., Zurbriggen, A., Stärk, K.D. :
Age-period-cohort analysis of the Bovine Spongiform Encephalopathy (BSE) epidemic in Switzerland. Prev Vet Med 66:19-33, 2004. Pubmed reference: 15579332. DOI: 10.1016/j.prevetmed.2004.07.009.
Green, R., Horrocks, C., Wilkinson, A., Hawkins, SA., Ryder, SJ. :
Primary isolation of the bovine spongiform encephalopathy agent in mice: agent definition based on a review of 150 transmissions. J Comp Pathol 132:117-31, 2004. Pubmed reference: 15737338. DOI: 10.1016/j.jcpa.2004.08.002.
Grobben, AH., Steele, PJ., Somerville, RA., Taylor, DM. :
Inactivation of the bovine-spongiform-encephalopathy (BSE) agent by the acid and alkaline processes used in the manufacture of bone gelatine. Biotechnol Appl Biochem 39:329-38, 2004. Pubmed reference: 15154846. DOI: 10.1042/BA20030149.
Hornemann, S., Schorn, C., Wüthrich, K. :
NMR structure of the bovine prion protein isolated from healthy calf brains. EMBO Rep 5:1159-64, 2004. Pubmed reference: 15568016. DOI: 10.1038/sj.embor.7400297.
Kaneko, K. :
[Bovine spongiform encephalopathy/ prion diseases] Nippon Naika Gakkai Zasshi 93:2363-8, 2004. Pubmed reference: 15624473.
Konold, T., Bone, G., Ryder, S., Hawkins, SA., Courtin, F., Berthelin-Baker, C. :
Clinical findings in 78 suspected cases of bovine spongiform encephalopathy in Great Britain. Vet Rec 155:659-66, 2004. Pubmed reference: 15581140.
Ledoux, JM. :
Hypothesis of interference to superinfection between bovine spastic paresis and bovine spongiform encephalopathy; suggestions for experimentation, theoretical and practical interest. Med Hypotheses 62:346-53, 2004. Pubmed reference: 14975501. DOI: 10.1016/j.mehy.2003.11.019.
Martin, TC., Moecks, J., Belooussov, A., Cawthraw, S., Dolenko, B., Eiden, M., Von Frese, J., Kohler, W., Schmitt, J., Somorjai, R., Udelhoven, T., Verzakov, S., Petrich, W. :
Classification of signatures of Bovine Spongiform Encephalopathy in serum using infrared spectroscopy. Analyst 129:897-901, 2004. Pubmed reference: 15457319. DOI: 10.1039/b408950m.
Morignat, E., Ducrot, C., Roy, P., Cohen, C., Calavas, D. :
Prevalence of BSE in cattle found dead, euthanased or emergency slaughtered on farms in western France in 2000, 2001 and 2002. Vet Rec 155:481-5, 2004. Pubmed reference: 15537142.
O'Rourke, K. :
O.I.E. takes action at annual meeting. Agency acts on measures involving BSE, zoonoses, animal welfare, and the disease notification system. J Am Vet Med Assoc 225:486-7, 2004. Pubmed reference: 15344347.
O'Rourke, K. :
O.I.E. takes action at annual meeting. Agency acts on measures involving BSE, zoonoses, animal welfare, and the disease notification system. J Am Vet Med Assoc 225:486-7, 2004.
Oliver, SP. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease. Foodborne Pathog Dis 1:65-72, 2004. Pubmed reference: 15992264. DOI: 10.1089/153531404772914482.
Sander, P., Hamann, H., Pfeiffer, I., Wemheuer, W., Brenig, B., Groschup, MH., Ziegler, U., Distl, O., Leeb, T. :
Analysis of sequence variability of the bovine prion protein gene (PRNP) in German cattle breeds. Neurogenetics 5:19-25, 2004. Pubmed reference: 14727152. DOI: 10.1007/s10048-003-0171-y.
Seabury, CM., Honeycutt, RL., Rooney, AP., Halbert, ND., Derr, JN. :
Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3. Proc Natl Acad Sci U S A 101:15142-7, 2004.
Seabury, CM., Honeycutt, RL., Rooney, AP., Halbert, ND., Derr, JN. :
Prion protein gene (PRNP) variants and evidence for strong purifying selection in functionally important regions of bovine exon 3. Proc Natl Acad Sci U S A 101:15142-7, 2004. Pubmed reference: 15477588. DOI: 10.1073/pnas.0406403101.
Seabury, CM., Womack, JE., Piedrahita, J., Derr, JN. :
Comparative PRNP genotyping of U.S. cattle sires for potential association with BSE. Mamm Genome 15:828-33, 2004. Pubmed reference: 15520885. DOI: 10.1007/s00335-004-2400-6.
Sisó, S., Ordóñez, M., Cordón, I., Vidal, E., Pumarola, M. :
Distribution of PrP(res) in the brains of BSE-affected cows detected by active surveillance in Catalonia, Spain. Vet Rec 155:524-5, 2004. Pubmed reference: 15551927.
Stack, MJ., Balachandran, A., Chaplin, M., Davis, L., Czub, S., Miller, B. :
The first Canadian indigenous case of bovine spongiform encephalopathy (BSE) has molecular characteristics for prion protein that are similar to those of BSE in the United Kingdom but differ from those of chronic wasting disease in captive elk and deer. Can Vet J 45:825-30, 2004. Pubmed reference: 15532881.
Wang, C., Geng, X., Wang, D., Tian, B. :
Purification of recombinant bovine normal prion protein PrP(104-242) by HPHIC. J Chromatogr B Analyt Technol Biomed Life Sci 806:185-90, 2004. Pubmed reference: 15171928. DOI: 10.1016/j.jchromb.2004.03.062.
2003 Anon. :
Federal funding intensifies prion disease research Journal of the American Veterinary Medical Association 222:12, 2003.
Bosch, X. :
Tracking spongiform encephalopathies in North America The Lancet Infectious Diseases 3:463, 2003. Pubmed reference: 12906010.
Brown, D.A., Bruce, M.E., Fraser, J.R. :
Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) in mice Neuropathology & Applied Neurobiology 29:262-72, 2003.
Cuenot, M., Calavas, D., Abrial, D., Gasqui, P., Cazeau, G., Ducrot, C. :
Temporal and spatial patterns of the clinical surveillance of BSE in France, analysed from January 1991 to May 2002 through a vigilance index Veterinary Research 34:261-72, 2003. Pubmed reference: 12791236. DOI: 10.1051/vetres:2003002.
Ducrot, C., Roy, P., Morignat, E., Baron, T., Calavas, D. :
How the surveillance system may bias the results of analytical epidemiological studies on BSE: prevalence among dairy versus beef suckler cattle breeds in France Veterinary Research 34:185-92, 2003. Pubmed reference: 12657210. DOI: 10.1051/vetres:2002065.
Ferguson, N.M., Donnelly, C.A. :
Assessment of the risk posed by bovine spongiform encephalopathy in cattle in Great Britain and the impact of potential changes to current control measures Proceedings of the Royal Society of London - Series B: Biological Sciences 270:1579-84, 2003. Pubmed reference: 12908978. DOI: 10.1098/rspb.2003.2484.
Ghani, A.C., Ferguson, N.M., Donnelly, C.A., Anderson, R.M. :
Factors determining the pattern of the variant Creutzfeldt-Jakob disease (vCJD) epidemic in the UK Proceedings of the Royal Society of London - Series B: Biological Sciences 270:689-98, 2003. Pubmed reference: 12713742. DOI: 10.1098/rspb.2002.2313.
Gizzi, G., van, Raamsdonk, L.W., Baeten, V., Murray, I., Berben, G., Brambilla, G., von, Holst, C. :
An overview of tests for animal tissues in feeds applied in response to public health concerns regarding bovine spongiform encephalopathy Revue Scientifique et Technique 22:311-31, 2003. Pubmed reference: 12793788.
Gravenor, M.B., Kao, R.R. :
Risk assessments on BSE Veterinary Record 152:816, 2003. Pubmed reference: 12862175.
Hoag, H. :
BSE case rattles Canadian officials Nature 423:467, 2003. Pubmed reference: 12774079. DOI: 10.1038/423467b.
Lasmezas, C.I. :
The transmissible spongiform encephalopathies Revue Scientifique et Technique 22:23-36, 2003. Pubmed reference: 12793772.
Matthews, D., Cooke, B.C. :
The potential for transmissible spongiform encephalopathies in non-ruminant livestock and fish Revue Scientifique et Technique 22:283-96, 2003. Pubmed reference: 12793786.
Morley, R.S., Chen, S., Rheault, N. :
Assessment of the risk factors related to bovine spongiform encephalopathy Revue Scientifique et Technique 22:157-78, 2003. Pubmed reference: 12793778.
Mostl, K. :
Bovine spongiform encephalopathy (BSE): the importance of the food and feed chain. Forum Nutr 56:394-6, 2003. Pubmed reference: 15806951.
Ozawa, Y. :
Risk management of transmissible spongiform encephalopathies in Asia Revue Scientifique et Technique 22:237-49, 2003. Pubmed reference: 12793782.
Prince, M.J., Bailey, J.A., Barrowman, P.R., Bishop, K.J., Campbell, G.R., Wood, J.M. :
Bovine spongiform encephalopathy Revue Scientifique et Technique 22:37-60, 2003. Pubmed reference: 12793773.
Roels, S., Walravens, K., Saegerman, C., Thelissen, M., Vanopdenbosch, E., Godfroid, J. :
Mycobacterium bovis meningitis in a cow with clinical signs of BSE Veterinary Record 152:807-8, 2003. Pubmed reference: 12862170.
Schreuder, B.E., Somerville, R.A. :
Bovine spongiform encephalopathy in sheep? Revue Scientifique et Technique 22:103-20, 2003. Pubmed reference: 12793775.
Sellier, P. :
Protein nutrition for ruminants in European countries, in the light of animal feeding regulations linked to bovine spongiform encephalopathy Revue Scientifique et Technique 22:259-69, 2003. Pubmed reference: 12793784.
Tahiri-Alaoui, A., Bouchard, M., Zurdo, J., James, W. :
Competing intrachain interactions regulate the formation of beta-sheet fibrils in bovine PrP peptides Protein Science 12:600-8, 2003. Pubmed reference: 12592030. DOI: 10.1110/ps.0236703.
Taylor, D.M., Woodgate, S.L. :
Rendering practices and inactivation of transmissible spongiform encephalopathy agents Revue Scientifique et Technique 22:297-310, 2003. Pubmed reference: 12793787.
van Gelderen, C., Gimeno, E.J., Schudel, A.A. :
Bovine spongiform encephalopathy in South America: a regional preventive approach Revue Scientifique et Technique 22:227-36, 2003. Pubmed reference: 12793781.
van't Hooft, A.J. :
[BSE: an additional explanation].[comment] Tijdschrift voor Diergeneeskunde 128:124, 2003. Pubmed reference: 12625162.
van't Hooft, A.J. :
[BSE-decision of minister Veerman a step in the right direction] Tijdschrift voor Diergeneeskunde 128:461, 2003. Pubmed reference: 12920930.
Walawski, K., Czarnik, U., Wojciechowski, R., Pareek, C.S. :
Abnormal segregation of prion protein octapeptide-repeat alleles in cattle Journal of Applied Genetics 44:375-8, 2003. Pubmed reference: 12923312.
Williams, E.S., Miller, M.W. :
Transmissible spongiform encephalopathies in non-domestic animals: origin, transmission and risk factors Revue Scientifique et Technique 22:145-56, 2003. Pubmed reference: 12793777.
2002 Agerholm, J.S., Tegtmeier, C.L., Nielsen, T.K. :
Survey of laboratory findings in suspected cases of bovine spongiform encephalopathy in Denmark from 1990 to 2000 APMIS 110:54-60, 2002. Pubmed reference: 12064256.
Aguzzi, A.A. :
The prion hypothesis and the human prion diseases Berliner und Munchener Tierarztliche Wochenschrift 115:91-98, 2002. Pubmed reference: 11938572.
Anon. :
Harvard study finds BSE poses little threat to US consumers, agriculture Journal of the American Veterinary Medical Association 220:279-280, 2002. Pubmed reference: 11829250.
Anon. :
LGC wins contract to screen cattle for BSE prion TRAC-Trends in Analytical Chemistry 21:V-VI, 2002.
Anon. :
Modelling the possibility of BSE in sheep Veterinary Record 150:91-92, 2002.
Anon. :
German scientists study BSE Australian Veterinary Journal 80:16, 2002.
Anon. :
Europe closes gaps for BSE Australian Veterinary Journal 80:16, 2002.
Anon. :
Finland has BSE: only Sweden 'safe' Australian Veterinary Journal 80:16, 2002. Pubmed reference: 12180864.
Anon. :
More cases of BSE in cows born after August 1, 1996 Veterinary Record 150:194, 2002.
Anon. :
BSE offspring cull to be tightened up Veterinary Record 150:227, 2002.
Anon. :
Embryo transfer and BSE Veterinary Record 150:357, 2002.
Anon. :
BAS cattle enter the food chain without being tested for BSE Veterinary Record 150:360, 2002.
Anon. :
Transmissible spongiform encephalopathy - Foreword Comptes Rendus Biologies 325:1, 2002.
Anon. :
New legislation on TSEs Veterinary Record 150:526, 2002.
Anon. :
BSE in sheep: new risk reduction measures published Veterinary Record 150:676, 2002.
Anon. :
Prions - Breeding BSE-immune cattle Chemistry & Industry :4, 2002.
Anon. :
French decide to lift ban on British beef Veterinary Record 151:430, 2002.
Anon. :
Study suggests under-reporting of BSE cases Veterinary Record 151:430, 2002.
Anon. :
BSE experimentally induced in a scrapie-resistant sheep Veterinary Record 151:619-620, 2002.
Aupperle, H., Schoon, H.A., Overhoff, M., Lucker, E. :
Procedures for the unwanted ingredients in meat products with regard to BSE - Immunohistochemical procedures for the detection of central and periphere nervous tissue in meat products Fleischwirtschaft 82:100-104, 2002.
Badiola, J.J., Monleon, E., Monzon, M., Acin, C., Lujan, L., Fernandez, D., Simmons, M., Vargas, A. :
Description of the first cases of BSE in Spain Veterinary Record 151:509-510, 2002. Pubmed reference: 12431000.
Baylis, M. :
The BSE-susceptible proportion of UK sheep Veterinary Record 151:481-482, 2002. Pubmed reference: 12418532.
Belay, E.D., Schonberger, L.B. :
Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy Clinics in Laboratory Medicine 22:849-62, v-vi, 2002. Pubmed reference: 12489284.
Bhakdi, S., Bohl, J. :
BSE - Prions and mad cows Fleischwirtschaft 82:16-+, 2002.
Blumberg-Mokri, M. :
The embargo on British beef Biofutur :50-51, 2002.
Bodemer, W., Kaup, F.J. :
Basic research on BSE transmission Deutsche Tierarztliche Wochenschrift 109:338-341, 2002. Pubmed reference: 12224460.
Bons, N., Lehmann, S., Mestre-Frances, N., Dormont, D., Brown, P. :
Brain and buffy coat transmission of bovine spongiform encephalopathy to the primate Microcebus murinus Transfusion 42:513-516, 2002. Pubmed reference: 12084158.
Borchers, K. :
Transmissible spongiform encephalopathies (TSE): Old diseases with new importance Berliner und Munchener Tierarztliche Wochenschrift 115:81-90, 2002. Pubmed reference: 11938571.
Borchers, K. :
Transmissible spongiform encephalopathies (TSE) - The agent and his characteristics Fleischwirtschaft 82:110-112, 2002.
Botteron, C. :
Diagnosis of transmissible spongiform encephalopathies in animals Schweizer Archiv fur Tierheilkunde 144:639-644, 2002. Pubmed reference: 12585204.
Bounias, M., Purdey, M. :
Transmissible spongiform encephalopathies: a family of etiologically complex diseases - a review Science of the Total Environment 297:1-19, 2002. Pubmed reference: 12389776.
Boyle, C. :
Review of the Spongiform Encephalopathy Advisory Committee Lancet 360:2075, 2002. Pubmed reference: 12504427. DOI: 10.1016/S0140-6736(02)11957-X.
Bradley, R. :
Bovine spongiform encephalopathy update Acta Neurobiologiae Experimentalis 62:183-195, 2002. Pubmed reference: 12416396.
Braun, U. :
Clinical signs and diagnosis of BSE Schweizer Archiv fur Tierheilkunde 144:645-652, 2002. Pubmed reference: 12585205.
Bruce, M.E., Boyle, A., Cousens, S., McConnell, I., Foster, J., Goldmann, W., Fraser, H. :
Strain characterization of natural sheep scrapie and comparison with BSE Journal of General Virology 83:695-704, 2002. Pubmed reference: 11842264.
Butler, D. :
Prion data suggest BSE link to sporadic CJD Nature 420:450, 2002. Pubmed reference: 12466801. DOI: 10.1038/420450a.
Chaplin, M.J., Barlow, N., Ryder, S., Simmons, M.M., Spencer, Y., Hughes, R., Stack, M.J. :
Evaluation of the effects of controlled autolysis on the immunodetection of PrPSc by immunoblotting and immunohistochemistry from natural cases of scrapie and BSE Research in Veterinary Science 72:37-43, 2002. Pubmed reference: 12002636. DOI: 10.1053/rvsc.2001.0518.
Cuadrado, A.I., Trevino, L.J., Lauffer, J.C., Ruiz, J.S. :
Mental disorders related to media influence: phobia and delusional disorder focused on the bovine spongiform encephalopathy mad cow disease Medicina Clinica 118:677-678, 2002.
Delgado-Hachmeister, J.E., Rangel-Frausto, M.S., de Leon, S.P. :
Transmissible spongiform encephalopathies. Salud Publica de Mexico 44:69-75, 2002. Pubmed reference: 11910722.
Doherr, M.G. :
Etiology, transmission and epidemiological situation of BSE in Europe Praktische Tierarzt 83:156-+, 2002.
Doherr, M.G., Hett, A.R., Cohen, C.H., Fatzer, R., Rufenacht, J., Zurbriggen, A., Heim, D. :
Trends in prevalence of BSE in Switzerland based on fallen stock and slaughter surveillance Veterinary Record 150:347-348, 2002. Pubmed reference: 11936885.
Doherr, M.G., Hett, A.R., Rufenacht, J., Zurbriggen, A., Heim, D. :
Geographical clustering of cases of bovine spongiform encephalopathy (BSE) born in Switzerland after the feed ban Veterinary Record 151:467-472, 2002. Pubmed reference: 12418529.
Farrugia, A. :
Laboratory practice and studies of bovine spongiform encephalopathy Lancet 359:1067-1068, 2002. Pubmed reference: 11937212. DOI: 10.1016/S0140-6736(02)08076-5.
Fatzer, R., Vandevelde, M., Gottstein, B. :
Cerebral taeniid oncospheral lesions in two BSE suspects Veterinary Record 150:46-47, 2002. Pubmed reference: 11829068.
Federspil, P., Federspil, P.A. :
Transmissible spongiform encephalopathies (prion diseases) HNO 50:316-326, 2002. Pubmed reference: 12063689.
Ferguson, N.M., Ghani, A.C., Donnelly, C.A., Hagenaars, T.J., Anderson, R.M. :
Estimating the human health risk from possible BSE infection of the British sheep flock Nature 415:420-424, 2002. Pubmed reference: 11786878. DOI: 10.1038/nature709.
Fleetwood, A. :
BSE in cattle born after July 31, 1996, in Great Britain Veterinary Record 151:551, 2002. Pubmed reference: 12448497.
Fraser, H. :
Origin of BSE Veterinary Record 151:616, 2002. Pubmed reference: 12463543.
Frey, J. :
Bovine spongiform encephalopathy: Are the cows mad or full of carbohydrates? Clinical Chemistry & Laboratory Medicine 40:101-103, 2002.
Ganter, M. :
Consequences of BSE/TSE for the clinical diagnostic in cattle and sheep Deutsche Tierarztliche Wochenschrift 109:342-344, 2002. Pubmed reference: 12224461.
Gareis, M. :
Meat and potential risks Deutsche Tierarztliche Wochenschrift 109:345-348, 2002. Pubmed reference: 12224462.
Glatzel, M., Gottwein, J., Aguzzi, A. :
The role of prions in transmissible spongiform encephalopathies Schweizer Archiv fur Tierheilkunde 144:633-638, 2002. Pubmed reference: 12585203.
Groschup, M.H., Stolze, A. :
The diagnostic system for BSE and scrapie in Germany Berliner und Munchener Tierarztliche Wochenschrift 115:106-110, 2002. Pubmed reference: 11938564.
Gunn, H.M., Lynch, D., Sheridan, H., Costelloe, A., Weavers, E., McElroy, M., Cooney, J., Sammin, D., Good, M., O'Sullivan, M., Caulfield, L., Kennedy, S., Smyth, K., Carr, M., Sheridan, J., Casey, V., Curley, L., Lynch, M., Gleeson, B. :
Alteration in age profile of BSE cases in Ireland Irish Veterinary Journal 55:84-85, 2002.
Gunn, M., Sheridan, H. :
BSE and scrapie - an update Irish Veterinary Journal 55:216-+, 2002.
Hanlon, J., Monks, E., Hughes, C., Weavers, E., Rogers, M. :
Metallothionein in bovine spongiform encephalopathy Journal of Comparative Pathology 127:280-289, 2002. Pubmed reference: 12443736.
Heeschen, W.H. :
BSE: Milk and potential risks? Deutsche Tierarztliche Wochenschrift 109:350-353, 2002. Pubmed reference: 12224463.
Heilemann, M. :
Disposal of animal byproducts, perished and slaughtered animals Deutsche Tierarztliche Wochenschrift 109:354-357, 2002. Pubmed reference: 12224464.
Heim, D., Kreysa, J. :
Risk assessment as an indicator for the distribution of BSE in the world Schweizer Archiv fur Tierheilkunde 144:710-715, 2002. Pubmed reference: 12585212.
Henson, S., Mazzocchi, M. :
Impact of bovine spongiform encephalopathy on agribusiness in the United Kingdom: Results of an event study of equity prices American Journal of Agricultural Economics 84:370-386, 2002.
Hernandez-Sanchez, J., Waddington, D., Wiener, P., Haley, C.S., Williams, J.L. :
Genome-wide search for markers associated with bovine spongiform encephalopathy Mammalian Genome 13:164-168, 2002. Pubmed reference: 11919688. DOI: 10.1007/s00335-001-3068-9.
Herrmann, R. :
Economic consequences of BSE in Germany Deutsche Tierarztliche Wochenschrift 109:358-361, 2002. Pubmed reference: 12224465.
Hett, A.R., Rufenacht, J., Perler, L., Heim, D. :
A method to identify BSE suspects in emergency slaughtered cattle during ante mortem examination Schweizer Archiv fur Tierheilkunde 144:654-662, 2002. Pubmed reference: 12585206.
Jasiorowski, H.A. :
BSE cases in Poland from the perspective of a cattle breeder Medycyna Weterynaryjna 58:849-851, 2002.
Kamphues, J. :
Feeding and feed legislation after the detection of the first indigenous BSE cases in Germany Deutsche Tierarztliche Wochenschrift 109:362-367, 2002. Pubmed reference: 12224466.
Kao, R.R., Gravenor, M.B., Baylis, M., Bostock, C.J., Chihota, C.M., Evans, J.C., Goldmann, W., Smith, A.J.A., McLean, A.R. :
The potential size and duration of an epidemic of bovine spongiform encephalopathy in British sheep Science 295:332-335, 2002. Pubmed reference: 11719694. DOI: 10.1126/science.1067475.
Kimura, K.M., Yokoyama, T., Haritani, M., Narita, M., Belleby, P., Smith, J., Spencer, Y.I. :
In situ detection of cellular and abnormal isoforms of prion protein in brains of cattle with bovine spongiform encephalopathy and sheep with scrapie by use of a histoblot technique Journal of Veterinary Diagnostic Investigation 14:255-257, 2002. Pubmed reference: 12033685.
Kretzschmar, H.A., Lederer, R.M. :
Prion diseases Ernahrungs-Umschau 49:216-+, 2002.
Liebman, S.W. :
Progress toward an ultimate proof of the prion hypothesis Proceedings of the National Academy of Sciences of the United States of America 99:9098-9100, 2002. Pubmed reference: 12093925. DOI: 10.1073/pnas.152318899.
Lucker, E., Schlottermuller, B., Martin, A. :
Studies on contamination of beef with tissues of the central nervous system (CNS) as pertaining to slaughtering technology and human BSE-exposure risk Berliner und Munchener Tierarztliche Wochenschrift 115:118-121, 2002. Pubmed reference: 11938566.
Lucker, E., Hardt, M., Groschup, M.H. :
Detection of CNS and PrPSc in meat products Berliner und Munchener Tierarztliche Wochenschrift 115:111-117, 2002. Pubmed reference: 11938565.
MacDiarmid, S.C. :
Bovine Spongiform Encephalopathy (BSE) in sheep? Australian Veterinary Journal 80:148-149, 2002. Pubmed reference: 12019700.
Moorby, J.M., Begley, P., Nash, R.J., Theodorou, M.K., Austin, A.R. :
Plasma metabolites indicate energy metabolism disruption during the preclinical phase of bovine spongiform encephalopathy infection Research in Veterinary Science 73:191-193, 2002. Pubmed reference: 12204641.
Narang, H. :
A critical review of the nature of the spongiform encephalopathy agent: Protein theory versus virus theory Experimental Biology & Medicine 227:4-19, 2002.
Paisley, L.G. :
Monitoring and analysis of bovine spongiform encephalopathy (BSE) testing in Denmark using statistical models APMIS 110:61-70, 2002. Pubmed reference: 12064257.
Perler, L., Guidon, D., Schmidt, J. :
The eradication of BSE: A touchstone for the Veterinary Services Schweizer Archiv fur Tierheilkunde 144:692-699, 2002. Pubmed reference: 12585210.
Polak, M.P., Rozek, W., Zmudzinski, J.F. :
BSE monitoring Medycyna Weterynaryjna 58:265-266, 2002.
Polak, M.P., Rozek, W., Rola, J., Larska, M., Zmudzinski, J.F., Kozaczynski, W., Reichert, M., Wijaszka, T., Ankiewicz, K., Pirog-Komorowska, A., Roels, S. :
First cases of BSE in Poland Medycyna Weterynaryjna 58:852-856, 2002.
Porta, M. :
Bovine spongiform encephalopathy, persistent organic pollutants, and the achievable utopias Journal of Epidemiology & Community Health 56:806-807, 2002.
Race, R.E., Raines, A., Baron, T.G.M., Miller, M.W., Jenny, A., Williams, E.S. :
Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle Journal of Virology 76:12365-12368, 2002. Pubmed reference: 12414979.
Roels, S., De, Meyer, G., Vanopdenbosch, E. :
Choroid plexus hyperplasia in an adult cow with clinical suspicion of bovine spongiform encephalopathy (BSE) Vlaams Diergeneeskundig Tijdschrift 71:359-361, 2002.
Safar, J.G., Scott, M., Monaghan, J., Deering, C., Didorenko, S., Vergara, J., Ball, H., Legname, G., Leclerc, E., Solforosi, L., Serban, H., Groth, D., Burton, D.R., Prusiner, S.B., Williamson, R.A. :
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice Nature Biotechnology 20:1147-1150, 2002. Pubmed reference: 12389035. DOI: 10.1038/nbt748.
Schaller, P., Schwermer, H., Heim, D. :
Twelve years experience in Switzerland: Quo vadis BSE? Schweizer Archiv fur Tierheilkunde 144:716-727, 2002. Pubmed reference: 12585213.
Schreuder, B.E.C., Wever, C.J.G. :
The possible origin of BSE in the Netherlands Tijdschrift voor Diergeneeskunde 127:40-49, 2002. Pubmed reference: 11831185.
Schutt-Abraham, I. :
Measures preventing BSE-contamination during the slaughter of cattle Berliner und Munchener Tierarztliche Wochenschrift 115:125-130, 2002. Pubmed reference: 11938568.
Schutt-Abraham, I. :
BSE prevention in live cattle Fleischwirtschaft 82:105-108, 2002.
Schwermer, H., Rufenacht, J., Doherr, M.G., Heim, D. :
Geographic distribution of BSE in Switzerland Schweizer Archiv fur Tierheilkunde 144:701-708, 2002. Pubmed reference: 12585211.
Soto, C. :
Altering prion replication for therapy and diagnosis of transmissible spongiform encephalopathies Biochemical Society Transactions 30:569-574, 2002. Pubmed reference: 12196139. DOI: 10.1042/.
Staufenbiel, R., Hamalainen, M. :
Aspects of clinical diagnosis of BSE Berliner und Munchener Tierarztliche Wochenschrift 115:99-105, 2002. Pubmed reference: 11938573.
Stoltenburg-Didinger, G. :
Prion diseases Fleischwirtschaft 82:107-110, 2002.
Taylor, D.M. :
Current perspectives on bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease Clinical Microbiology & Infection 8:332-339, 2002.
Troeger, K. :
BSE-consequences for slaughtering, cutting and employer's protection Deutsche Tierarztliche Wochenschrift 109:368-371, 2002. Pubmed reference: 12224467.
Van Everbroeck, B., Pals, P., Martin, J.J., Cras, P. :
Transmissible spongiform encephalopathies: the story of a pathogenic protein Peptides 23:1351-1359, 2002. Pubmed reference: 12128092.
van't Hooft, A.J.G. :
Mad cow disease and species-specific barriers Tijdschrift voor Diergeneeskunde 127:175, 2002. Pubmed reference: 11905243.
von Alvensleben, R. :
Effects of BSE on consumer attitudes and behaviour Deutsche Tierarztliche Wochenschrift 109:335-337, 2002. Pubmed reference: 12224459.
Wahlstrom, H., Elvander, M., Engvall, A., Vagsholm, I. :
Risk of introduction of BSE into Sweden by import of cattle from the United Kingdom Preventive Veterinary Medicine 54:131-139, 2002. Pubmed reference: 12069776.
Weissmann, C., Enari, M., Klohn, P.C., Rossi, D., Flechsig, E. :
Transmission of prions Proceedings of the National Academy of Sciences of the United States of America 99:16378-16383, 2002. Pubmed reference: 12181490. DOI: 10.1073/pnas.172403799.
Westaway, D., Carlson, G.A. :
Mammalian prion proteins: enigma, variation and vaccination Trends in Biochemical Sciences 27:301-307, 2002. Pubmed reference: 12069790.
Wiemer, U. :
Measures taken with regard to BSE under veterinary law Berliner und Munchener Tierarztliche Wochenschrift 115:134-139, 2002. Pubmed reference: 11938570.
Wiemer, U. :
BSE - present and future legal requirements Deutsche Tierarztliche Wochenschrift 109:372-374, 2002. Pubmed reference: 12224468.
Wilesmith, J.W. :
Preliminary epidemiological analyses of the first 16 cases of BSE born after July 31, 1996, in Great Britain Veterinary Record 151:451-452, 2002. Pubmed reference: 12408330.
Wilesmith, J.W. :
BSE in cattle born after July 31, 1996, in Great Britain - Professor John Wilesmith comments Veterinary Record 151:552, 2002.
Wilks, C.R. :
European surveillance for BSE and transmission with blood Australian Veterinary Journal 80:553, 2002. Pubmed reference: 12398318.
Williams, E.S. :
The transmissible spongiform encephalopathies: disease risks for North America Veterinary Clinics of North America - Food Animal Practice 18:461-+, 2002.
Wood, H. :
Are sheep safe? Nature Reviews Neuroscience 3:82, 2002.
Wood, H. :
Prion diseases - Behavioural clues to TSEs Nature Reviews Neuroscience 3:673, 2002.
Wrathall, A.E., Brown, K.F.D., Sayers, A.R., Wells, G.A.H., Simmons, M.M., Farrelly, S.S.J., Bellerby, P., Squirrell, J., Spencer, Y.I., Wells, M., Stack, M.J., Bastiman, B., Pullar, D., Scatcherd, J., Heasman, L., Parker, J., Hannam, D.A.R., Helliwell, D.W., Chree, A., Fraser, H. :
Studies of embryo transfer from cattle clinically affected by bovine spongiform encephalopathy (BSE) Veterinary Record 150:365-378, 2002. Pubmed reference: 11936410.
Yam, P. :
Keeping the mad cows at bay - Veterinarian Linda A. Detwiler helps to ensure that a fatal brain disease that can afflict humans doesn't appear in US cattle. It can be a thankless task Scientific American 287:38-39, 2002.
Zentek, J., Oberthur, R.C., Kamphues, J., Kreienbrock, L., Flachowsky, G., Coenen, M. :
Risk assessment for animal derived feedstuffs as vectors for bovine spongiform encephalopathy (BSE) in Germany. Part 2: Compounded feed as vector for bovine spongiform encephalopathy (BSE) in Germany. Deutsche Tierarztliche Wochenschrift 109:43-51, 2002. Pubmed reference: 11889841.
2001 Abbott, A. :
Mad-cow outbreak spurs German drive to combat prion diseases Nature 412:571-572, 2001. Pubmed reference: 11493878. DOI: 10.1038/35088183.
Adam, D. :
Review blames BSE outbreak on calf feed Nature 412:467, 2001. Pubmed reference: 11484009. DOI: 10.1038/35087720.
Anon :
DEFRA extends surveillance for BSE and scrapie Veterinary Record 149:758, 2001.
Anon. :
BSE confirmed in Japan Veterinary Record 149:371-372, 2001.
Anon. :
BSE inspection checklist available online Journal of the American Veterinary Medical Association 219:1193, 2001.
Anon. :
Dutch BSE cases merit research into genetic etiology Tijdschrift voor Diergeneeskunde 126:565, 2001.
Anon. :
Government expands its BSE testing programme Veterinary Record 149:635-636, 2001.
Anon. :
Bovine spongiform encephalopathy (BSE) Australian Veterinary Journal 79:16, 2001. Pubmed reference: 11221559.
Anon. :
BSE has made 'stars' of European veterinarians Australian Veterinary Journal 79:92, 2001.
Anon. :
Iceland nearly closed by neighbours and BSE Australian Veterinary Journal 79:92, 2001.
Anon. :
Response to BSE inquiry 'light on future action' Veterinary Record 148:226, 2001.
Anon. :
Transparency and openness: The Government's response to the BSE Inquiry Veterinary Record 148:190-193, 2001. Pubmed reference: 11265994.
Anon. :
The Audit and the way to a BSE-free national herd Irish Veterinary Journal 54:97, 2001.
Anon. :
More than just mad cow disease Nature Structural Biology 8:281, 2001. Pubmed reference: 11276238. DOI: 10.1038/86132.
Anon. :
BSE testing results Veterinary Record 148:615, 2001.
Anon. :
BSE monitoring: MAFF announces testing of fallen stock Veterinary Record 148:64, 2001.
Anon. :
Results of targeted surveillance for BSE in French cattle Veterinary Record 149:35, 2001.
Anon. :
Second case of BSE in a cow born after August 1, 1996 Veterinary Record 149:4, 2001.
Anon. :
'Encouraging' results of BSE testing in Europe Veterinary Record 148:794-795, 2001.
Anon. :
Health authorities find BSE in Czech Republic, vCJD in Hong Kong Journal of the American Veterinary Medical Association 219:294, 2001.
Anon. :
The French reflect on BSE Australian Veterinary Journal 79:452, 2001. Pubmed reference: 11549039.
Anon. :
Further case of BSE in a cow born after August 1, 1996 Veterinary Record 149:66, 2001.
Anon. :
Ole, inspite of BSE - Spain's toreros protest against regulations forbidding the marketing of meat from animals used in bullfights Fleischwirtschaft 81:54, 2001.
Anon. :
Review of the origin of BSE: scrapie agent cannot be excluded Veterinary Record 149:98-99, 2001. Pubmed reference: 11504215.
Anon. :
Summary and conclusions of the review of the origin of BSE Veterinary Record 149:98-99, 2001.
Anon. :
Fifteen years of bovine spongiform encephalopathy - the facts, the figures, the hopes and the fears Irish Veterinary Journal 54:448-452, 2001.
Axelsson, S. :
The basic reality of mind and spongiform diseases Medical Hypotheses 57:549-554, 2001. Pubmed reference: 11735309. DOI: 10.1054/mehy.2001.1387.
Balter, M. :
Origins of BSE - Intriguing clues to a scrapie-mad cow link Science 292:827-+, 2001. Pubmed reference: 11341262.
Barnard, G. :
The measurement of prion protein in bovine brain tissue using differential extraction and DELFIA (R) as a diagnostic test for BSE (vol 15, pg 357, 2000) Luminescence 16:211, 2001.
Beutgen, M. :
Natural casings - A sign of German eating habits - Regulations for natural casings after the BSE crisis Fleischwirtschaft 81:51-52, 2001.
Bonetta, L. :
More sensitive tests for BSE needed Nature Medicine 7:261, 2001. Pubmed reference: 11231599. DOI: 10.1038/85359.
Bosch, X. :
BSE panic spreads to Spain Nature Medicine 7:138, 2001. Pubmed reference: 11175828. DOI: 10.1038/84553.
Bradley, R. :
Bovine spongiform encephalopathy and its relationship to the new variant form of Creutzfeldt Jakob disease PRIONS : A CHALLENGE FOR SCIENCE, MEDICINE AND PUBLIC HEALTH SYSTEM 7:105-144, 2001.
Brown, P., Will, R.G., Bradley, R., Asher, D.M., Detwiler, L. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: Background, evolution, and current concerns Emerging Infectious Diseases 7:6-16, 2001. Pubmed reference: 11266289.
Brown, P. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease British Medical Journal 322:841-844, 2001. Pubmed reference: 11290640.
Brown, P. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease (vol 322, pg 841, 2001) BMJ 322:1166, 2001.
Brown, P. :
Afterthoughts about bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease Emerging Infectious Diseases 7:598-600, 2001. Pubmed reference: 11485682.
Brugere-Picoux, J., Brugere, H. :
Bovine spongiform encephalopathy: A turning point in the evolution of the epidemic? Revue de Medecine Interne 22:693-698, 2001. Pubmed reference: 11534354.
Butler, D. :
Poor practices led to BSE brains mix-up, say auditors Nature 414:569, 2001. Pubmed reference: 11740512. DOI: 10.1038/414569b.
Butler, D. :
Brain mix-up leaves BSE research in turmoil Nature 413:760, 2001. Pubmed reference: 11677560. DOI: 10.1038/35101729.
Calavas, D., Ducrot, C., Baron, T., Morignat, E., Vinard, J.L., Biacabe, A.G., Madec, J.Y., Bencsik, A., Debeer, S., Eliazsewicz, M. :
Prevalence of BSE in western France by screening cattle at risk: preliminary results of a pilot study Veterinary Record 149:55-56, 2001. Pubmed reference: 11488343.
Carson, C., McKay, J.S., Brooks, H.W., Kelly, D.F., Stidworthy, M.F., Wibbelt, G., Morgan, K.L. :
Establishment and maintenance of a longitudinal study of bovine spongiform encephalopathy (the ULiSES scheme) Preventive Veterinary Medicine 51:245-257, 2001. Pubmed reference: 11535283.
Caughey, B., Chesebro, B. :
Transmissible spongiform encephalopathies and prion protein interconversions Advances in Virus Research 56:277-311, 2001.
Charatan, F. :
US takes precautions against bovine spongiform encephalopathy BMJ 322:128, 2001.
Cooley, W.A., Clark, J.K., Ryder, S.J., Davis, L.A., Farrelly, S.S.J., Stack, M.J. :
Evaluation of a rapid western immunoblotting procedure for the diagnosis of bovine spongiform encephalopathy (BSE) in the UK Journal of Comparative Pathology 125:64-70, 2001. Pubmed reference: 11437518. DOI: 10.1053/jcpa.2001.0478.
Cooper, J.D., Bird, S.M. :
Analysis of the bovine spongiform encephalopathy maternal cohort study, revisited JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C-APPLIED STATISTICS 50:313-324, 2001.
Cyranoski, D. :
Japan's first BSE case fuels fears elsewhere Nature 413:337, 2001. Pubmed reference: 11574838. DOI: 10.1038/35096710.
Dack, M. :
BSE update - quick response to European beef ban Food Australia 53:124, 2001.
Debeer, S.O.S., Baron, T.G.M., Bencsik, A.A. :
Immunohistochemistry of PrPsc within bovine spongiform encephalopathy brain samples with graded autolysis Journal of Histochemistry & Cytochemistry 49:1519-1524, 2001. Pubmed reference: 11724899.
Deslys, J.P., Lasmezas, C.I., Comoy, E., Domont, D. :
Diagnosis of bovine spongiform encephalopathy Veterinary Journal 161:1-3, 2001.
Edel, W. :
Animal meal and BSE Tijdschrift voor Diergeneeskunde 126:38, 2001.
Enserink, M. :
Prion diseases - US gets tough against chronic wasting disease Science 294:978-979, 2001. Pubmed reference: 11691964. DOI: 10.1126/science.294.5544.978.
Enserink, M. :
Infectious diseases - Is the US doing enough to prevent mad cow disease? Science 292:1639-1641, 2001. Pubmed reference: 11387458. DOI: 10.1126/science.292.5522.1639.
Entel, S.A. :
The defaming of a line of business or the BSE scandal and its impact Fleischwirtschaft 81:79-82, 2001.
Eskens, U. :
Bovine spongiform encephalopathy (BSE) Transmissible spongiform encephalopathy Mad cow disease Environmental Science & Pollution Research 8:79-83, 2001.
Fankanel, S. :
Efficacy of BSE tests Ernahrungs-Umschau 48:B5-B6, 2001.
Fankhanel, S. :
Impact of mad cow disease in Germany Ernahrungs-Umschau 48:45, 2001.
Ferguson-Smith, M.A. :
BSE and variant CJD - Assumption that BSE originated from scrapie in sheep led to misjudgment British Medical Journal 322:1544-1545, 2001. Pubmed reference: 11439995.
Freiberg, B., Unglaub, W. :
BSE-test (Bio-Rad ELISA) with autolytic brain material - An orientating investigation Fleischwirtschaft 81:111-113, 2001.
Giles, J. :
Mad cow disease comes to Japan Nature 413:240, 2001. Pubmed reference: 11564996. DOI: 10.1038/35095180.
Gill, D.S., Tredwin, C.J., Gill, S.K., Ironside, J.W. :
The transmissible spongiform encephalopathies (prion diseases): A review for dental surgeons International Dental Journal 51:439-446, 2001. Pubmed reference: 11789711.
Grassi, J., Comoy, E., Simon, S., Creminon, C., Frobert, Y., Trapmann, S., Schimmel, H., Hawkins, S.A.C., Moynagh, J., Deslys, J.R., Wells, G.A.H. :
Rapid test for the preclinical postmortem diagnosis of BSE in central nervous system tissue Veterinary Record 149:577-582, 2001. Pubmed reference: 11730165.
Gunn, M. :
Observations on disposal of BSE-infected carcasses Irish Veterinary Journal 54:192-193, 2001.
Hateley, G. :
EU requirement to survey for BSE in fallen stock: consequences for postmortem examination Veterinary Record 149:660, 2001. Pubmed reference: 11764335.
Haunhorst, E. :
BSE regulations - Measures taken by countries should guarantee consumer protection Fleischwirtschaft 81:20-22, 2001.
Hills, D., Comincini, S., Schlaepfer, J., Dolf, G., Ferretti, L., Williams, J.L. :
Complete genomic sequence of the bovine prion gene (PRNP) and polymorphism in its promoter region Animal Genetics 32:231-232, 2001. Pubmed reference: 11531705.
Hinchliffe, S. :
Indeterminacy in-decisions - science, policy and politics in the BSE (Bovine Spongiform Encephalopathy) crisis Transactions of the Institute of British Geographers 26:182-204, 2001.
Jeffcott, L.B., Jeffries, A., Mueller, K. :
EU requirement to survey for BSE in fallen stock: consequences for postmortem examination Veterinary Record 149:631, 2001. Pubmed reference: 11761298.
Jeffrey, M., Martin, S., Gonzalez, L., Ryder, S.J., Bellworthy, S.J., Jackman, R. :
Differential diagnosis of infections with the bovine spongiform encephalopathy (BSE) and scrapie agents in sheep Journal of Comparative Pathology 125:271-284, 2001. Pubmed reference: 11798244. DOI: 10.1053/jcpa.2001.0499.
Jones, T.O. :
vCJD in Leicestershire Veterinary Record 149:64, 2001. Pubmed reference: 11488351.
Kamphues, J., Zentek, J., Oberthur, R.C., Flachowsky, G., Coenen, M. :
Risk assessment for animal derived feedstuffs as vectors for bovine spongiform encephalopathy (BSE) in Germany. Part I: Comparative risk assessment for animal derived feedstuffs. Deutsche Tierarztliche Wochenschrift 108:283-290, 2001. Pubmed reference: 11505845.
Kingombe, C.I.B., Luthi, E., Schlosser, H., Howald, D., Kuhn, M., Jemmi, T. :
A PCR-based test for species-specific determination of heat treatment conditions of animal meals as an effective prophylactic method for bovine spongiform encephalopathy Meat Science 57:35-41, 2001.
Kolb, E. :
Are there inter-relationships between the BSE and transmissible mink encephalopathy? Did BSE exist before 1985? Tierarztliche Umschau 56:507-511, 2001.
Kolb, E. :
Recent studies on the properties of the infectious molecules of BSE and sheep scrapie and means of infection Tierarztliche Umschau 56:175-+, 2001.
Kramer, R. :
BSE crisis sinks German public biotech programme (vol 409, pg 549, 2001) Nature 410:9, 2001. Pubmed reference: 11242009. DOI: 10.1038/35065244.
Krammer, R. :
BSE crisis sinks German public biotech programme Nature 409:549, 2001. Pubmed reference: 11214287. DOI: 10.1038/35054693.
Kuzma, C.D. :
BSE: Could it happen here? Experts say probably not Journal of the American Veterinary Medical Association 218:646-+, 2001. Pubmed reference: 11280387.
Laffling, A.J., Baird, A., Birkett, C.R., John, H.A. :
A monoclonal antibody that enables specific immunohistological detection of prion protein in bovine spongiform encephalopathy cases Neuroscience Letters 300:99-102, 2001. Pubmed reference: 11207384.
Lam, T.J.G.M., Urlings, H.A.P. :
Is it a good strategy to destroy all the animals of a farm if only one animal has BSE? Response Tijdschrift voor Diergeneeskunde 126:114-115, 2001.
Lasmezas, C.I., Fournier, J.G., Nouvel, V., Boe, H., Marce, D., Lamoury, F., Kopp, N., Hauw, J.J., Ironside, J., Bruce, M., Dormont, D., Deslys, J.P. :
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: Implications for human health Proceedings of the National Academy of Sciences of the United States of America 98:4142-4147, 2001. Pubmed reference: 11259641. DOI: 10.1073/pnas.041490898.
Lorenzen, S. :
BSE is not a natural disaster but man made - How can the BSE-crisis be solved in dignity? Fleischwirtschaft 81:127-133, 2001.
Lucker, E., Schlottermuller, B. :
Procedures for the detection of unwanted ingredients in meat products with regard to BSE - 5. Detection of central nervous tissue in heat-treated meat products Fleischwirtschaft 81:102-107, 2001.
MacKnight, C. :
Clinical implications of bovine spongiform encephalopathy Clinical Infectious Diseases 32:1726-1731, 2001. Pubmed reference: 11360215. DOI: 10.1086/320760.
Manning, R. :
BSE/FMD - time for serious bans Australian Veterinary Journal 79:320, 2001.
McElroy, M.C., Weavers, E.D. :
Clinical presentation of bovine spongiform encephalopathy in the Republic of Ireland Veterinary Record 149:747-748, 2001. Pubmed reference: 11808659.
McGill, I. :
Phillips report and the origin of BSE Veterinary Record 148:60, 2001. Pubmed reference: 11202558.
Murphy, C., Breen, C., Rogers, M., Giese, M. :
Interferon gamma and prostaglandin in BSE-infected cattle Cytokine 13:169-173, 2001. Pubmed reference: 11161460. DOI: 10.1006/cyto.2000.0805.
Negro, A., Ballarin, C., Bertoli, A., Massimino, M.L., Sorgato, M.C. :
The metabolism and imaging in live cells of the bovine prion protein in its native form or carrying single amino acid substitutions Molecular & Cellular Neuroscience 17:521-538, 2001.
O'Farrell, K. :
Strategy for restocking of Moorepark after depopulation following bovine spongiforum encepalopathy (vol 54, pg 74, 2001) Irish Veterinary Journal 54:102, 2001.
Overgaauw, P.A.M. :
Mad cow disease and food for animals: Is pet food still safe? Tijdschrift voor Diergeneeskunde 126:292, 2001. Pubmed reference: 11338622.
Pepys, H.B., Collinge, J., Barron, L.D., Masel, J., Tahari-Alaoui, A., Lansbury, P., Exley, C., Feizi, T. :
The molecular biology of prion propagation - Discussion Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences 356:194-195, 2001.
Polak, M.P., Zmudzinski, J.F. :
BSE in Europe - epizootiological data Medycyna Weterynaryjna 57:228-232, 2001.
Prange, H. :
Assessment of BSE risks and the related social crisis - Editorial Tierarztliche Umschau 56:171-175, 2001.
Reilly, J. :
AQIS fails Aust on BSE Australian Veterinary Journal 79:320, 2001.
Riemann, H. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease Emerging Infectious Diseases 7:605, 2001. Pubmed reference: 11485685.
Roels, S., De, Meyer, G., Vanopdenbosch, E. :
Bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease: some information concerning the origin, diagnosis, epidemiology, risk analysis and future. Annales de Medecine Veterinaire 145:333-341, 2001.
Rossides, S. :
Meat and bone meal still used in animal feed Nature 414:147, 2001. Pubmed reference: 11700522. DOI: 10.1038/35102729.
Saegerman, C., Dechamps, P., Roels, S., Petroff, K., Geeroms, R., Torck, G., Dufey, J., Fourez, R., Hamelryckx, M., Cormann, A., Viatour, P., De, Coninck, V., Lomba, F., Vermeersch, J.P., Hallet, L., Lhost, O., Leemans, M., Vandersanden, A., Peharpre, D., Brochier, B., Costy, E., Pastoret, P.P., Thiry. :
Epidemiosurveillance of bovine spongiform encephalopathy in Belgium in 1999 Annales de Medecine Veterinaire 145:47-+, 2001.
Schiermeier, Q. :
Testing times for BSE Nature 409:658-659, 2001. Pubmed reference: 11217833. DOI: 10.1038/35055703.
Schwagele, F. :
Information about BSE - Possibilities and limits of analysis Fleischwirtschaft 81:143-145, 2001.
Schwartz, D.A. :
First funding for US research into bovine spongiform encephalopathy (BSE) expected for 2002 Chemical Innovation 31:5, 2001.
Scudamore, J.M. :
EU requirement to survey for BSE in fallen stock: consequences for postmortem examination Veterinary Record 149:778, 2001. Pubmed reference: 11808669.
Spurgeon, D. :
Canada's BSE fears 'groundless' Nature 409:968, 2001. Pubmed reference: 11234032. DOI: 10.1038/35059273.
Stockdale, T. :
A biochemical theory to explain the cause of bovine spongiform encephalopathy and other encephalopathies Medical Hypotheses 56:608-616, 2001. Pubmed reference: 11399107. DOI: 10.1054/mehy.2000.1282.
Tagaya, M. :
BSE fostered by cosinesss and lack of independent advice Nature 414:147, 2001. Pubmed reference: 11700521. DOI: 10.1038/35102727.
Taylor, D.M., Fernie, K., Steele, P.J., Somerville, R.A. :
Relative efficiency of transmitting bovine spongiform encephalopathy to RIII mice by the oral route Veterinary Record 148:345-346, 2001. Pubmed reference: 11316294.
Tegtmeier, C., Agerholm, J.S., Bille-Hansen, V., Schaap, P.K., Ryder, S. :
First confirmed native case of bovine spongiform encephalopathy in Denmark Veterinary Record 148:51-52, 2001. Pubmed reference: 11202554.
Tranulis, M.A., Espenes, A., Comincini, S., Skretting, G., Harbitz, I. :
The PrP-like protein Doppel gene in sheep and cattle: cDNA sequence and expression Mammalian Genome 12:376-379, 2001. Pubmed reference: 11331946. DOI: 10.1007/s003350010285.
Urlings, B., Bianchi, A. :
BSE testing in the Netherlands Tijdschrift voor Diergeneeskunde 126:46-49, 2001. Pubmed reference: 11204929.
Urlings, H.A.P., van, Zijderveld, F.G. :
Active surveillance of BSE in cattle in the Netherlands Veterinary Quarterly 23:134-138, 2001. Pubmed reference: 11513256.
van't Hooft, A.J.G. :
Making genetic factors of BSE visible by cloning cattle Tijdschrift voor Diergeneeskunde 126:664-665, 2001. Pubmed reference: 11699437.
van, Wuijckhuise, L., Vellema, P., Terbijhe, R.J. :
BSE: Clinical diagnosis and field experiences Tijdschrift voor Diergeneeskunde 126:279-281, 2001. Pubmed reference: 11338617.
Volpina, O.M., Zhmak, M.N., Oboznaya, M.B., Titova, M.A., Koroev, D.O., Volkova, T.D., Egorov, A.A., Rybakov, S.S., Ivanov, V.T. :
Antibodies against synthetic fragments of the prion protein for diagnostics of bovine spongiform encephalopathy Russian Journal of Bioorganic Chemistry 27:311-317, 2001.
Watts, J. :
Bovine spongiform encephalopathy case found in Japan Lancet 358:991, 2001. Pubmed reference: 11583764.
Wenz, B., Oesch, B., Horst, M. :
Analysis of the risk of transmitting bovine spongiform encephalopathy through bone grafts derived from bovine bone Biomaterials 22:1599-1606, 2001. Pubmed reference: 11374460.
Worswick, R. :
BSE record set straight Nature 414:249, 2001. Pubmed reference: 11713498. DOI: 10.1038/35104785.
Ziebolz, B. :
Greater safety with beef - The Prionics (R)-Check LIA for fully automated BSE testing Fleischwirtschaft 81:20-21, 2001.
2000 Aldhous, P. :
CJD survey offers Britain a glimmer of hope Nature 405:7, 2000. Pubmed reference: 10811187. DOI: 10.1038/35011219.
Anon. :
Lab test for prions may yield diagnostic tool for TSE diseases Large Animal Practice 21:7, 2000.
Anon. :
Study links BSE and deadly human brain disease Journal of the American Veterinary Medical Association 216:473, 2000.
Anon. :
The BSE inquiry: chairman's closing statement Veterinary Record 146:2-3, 2000. Pubmed reference: 10661451.
Anon. :
UK and France still at 'war' over BSE Australian Veterinary Journal 78:130, 2000.
Anon. :
BSE inquiry: report delayed until September Veterinary Record 146:203, 2000.
Anon. :
CJD and the spongiform encephalopathies British Journal of Ophthalmology 84:346, 2000.
Anon. :
vCJD statistics to include 'probable' cases Veterinary Record 146:359, 2000.
Anon. :
Germany lifts ban on British beef Veterinary Record 146:359, 2000.
Anon. :
BSE: new guidelines from MAFF Veterinary Record 146:743-744, 2000.
Anon. :
BSE still a big problem - EU had 3000 cases in 1999 Australian Veterinary Journal 78:230, 2000.
Anon. :
BSE confirmed in a cow born after August 1, 1996 Veterinary Record 147:30, 2000.
Anon. :
Variant CJD: initial findings from human tissue survey Veterinary Record 146:538, 2000.
Anon. :
SEAC comments on rise in vCJD cases Veterinary Record 147:86, 2000.
Anon. :
But what do normal prions do? Nature Medicine 6:1107, 2000. Pubmed reference: 11017140. DOI: 10.1038/80439.
Anon. :
Mad cows cast long shadows Nature 407:929, 2000.
Anon. :
BSE and vCJD: causes, controls and concerns Veterinary Record 147:405-406, 2000. Pubmed reference: 11072983.
Anon. :
Acting on the lessons of BSE Veterinary Record 147:525, 2000.
Anon. :
Report says low risk of BSE occurring in US Journal of the American Veterinary Medical Association 217:1781-1782, 2000.
Anon. :
FSA welcomes European decision on BSE controls Veterinary Record 147:699, 2000.
Anon. :
BSE: assessing the risks from French imports Veterinary Record 147:727, 2000.
Anon. :
Of BSE, surveillance, and the veterinary surgeon's privilege to dispense Veterinary Record 147:403-404, 2000. Pubmed reference: 11072982.
Anon. :
Global infection - It's official: even in countries that deny it, some cattle are likely to be harbouring BSE New Scientist 166:4, 2000.
Balter, M. :
Tracking the human fallout from 'mad cow disease' Science 289:1452-1454, 2000. Pubmed reference: 10991726.
Balter, M. :
Spongiform disease - Experts downplay new vCJD fears Science 289:1663-+, 2000. Pubmed reference: 11001722.
Barnard, G., Helmick, B., Madden, S., Gilbourne, C., Patel, R. :
The measurement of prion protein in bovine brain tissue using differential extraction and DELFIA (R) as a diagnostic test for BSE Luminescence 15:357-362, 2000. Pubmed reference: 11114111. DOI: 10.1002/1522-7243(200011/12)15:6<357::AID-BIO621>3.0.CO;2-V.
Baron, T.G.M., Madec, J.Y., Calavas, D., Richard, Y., Barillet, F. :
Comparison of French natural scrapie isolates with bovine spongiform encephalopathy and experimental scrapie infected sheep Neuroscience Letters 284:175-178, 2000. Pubmed reference: 10773427.
Birchard, K. :
BSE-testing time for European cattle Lancet 355:1252, 2000. Pubmed reference: 11657898. DOI: 10.1016/S0140-6736(05)74697-3.
Bruce, M.E. :
'New variant' Creutzfeldt-Jakob disease and bovine spongiform encephalopathy Nature Medicine 6:258-259, 2000. Pubmed reference: 10700223. DOI: 10.1038/73098.
Butler, D. :
French target research money at allaying BSE fears Nature 408:392, 2000. Pubmed reference: 11100691. DOI: 10.1038/35044229.
Casassus, B. :
Mad cow disease - New recruits for French prion research Science 290:1671, 2000. Pubmed reference: 11186383.
Chapron, Y., Peyrin, J.M., Crouzy, S., Jaegly, A., Dormont, D. :
Theoretical analysis of the implication of PrP in neuronal death during transmissible subacute spongiform encephalopathies: Hypothesis of a PrP oligomeric channel Journal of Theoretical Biology 204:103-111, 2000. Pubmed reference: 10772851. DOI: 10.1006/jtbi.2000.1091.
Chen, S.G., Parchi, P., Gambetti, P. :
Prion diseases including bovine spongiform encephalopathy (mad cow disease) SCIENCE OF GERIATRICS VOL 1 AND 2 1-2:491-502, 2000.
Cockcroft, P.D. :
Clinical sign profile likelihood ratios for bovine spongiform encephalopathy suspects Research in Veterinary Science 68:285-290, 2000. Pubmed reference: 10877977. DOI: 10.1053/rvsc.2000.0379.
Coghlan, A. :
Reservoir sheep - Did BSE start in sheep, and could it still be lurking there? New Scientist 167:20, 2000.
Cooper, J.H. :
Did cannibalisin and spongiform encephalopathy contribute to the demise of the Neanderthals? Mankind Quarterly 41:175-180, 2000.
Deptula, W., Pawlikowska, M. :
Pathogenesis of prion diseases [Review] [Polish] Medycyna Weterynaryjna 56:11-14, 2000.
Detwiler, L.A., Rubenstein, R. :
Bovine spongiform encephalopathy: An overview ASAIO Journal 46:S73-S79, 2000. Pubmed reference: 11110298.
Dickson, D. :
UK ministry under fire over handling of BSE research Nature 407:932, 2000. Pubmed reference: 11069147. DOI: 10.1038/35039687.
Donnelly, C.A. :
Likely size of the French BSE epidemic - Epidemiological analysis helps in evaluating the potential risks of eating French beef. Nature 408:787-788, 2000. Pubmed reference: 11130705. DOI: 10.1038/35048666.
Fraser, H. :
Phillips report and the origin of BSE Veterinary Record 147:724, 2000. Pubmed reference: 11140936.
Ganter, M., Rehage, J., Kaske, M. :
Consequences of the new "decree about the surveilance of transmissible spongiform encephalopathies" for the veterinarian [German] Praktische Tierarzt 81:44-+, 2000.
Ganter, M., Rehage, J., Kaske, M. :
Consequences for the veterinarians of the new regulation concerning the control of transmissible spongiform encephalopathies [Hungarian] Magyar Allatorvosok Lapja 122:346-351, 2000.
Garcia, F.L., Zahn, R., Riek, R., Wuthrich, K. :
NMR structure of the bovine prion protein Proceedings of the National Academy of Sciences of the United States of America 97:8334-8339, 2000. Pubmed reference: 10899999.
Gavaghan, H. :
UK mad cow disease - Report flags hazards of risk assessment Science 290:911-+, 2000. Pubmed reference: 11184726.
Ghani, A.C., Ferguson, N.M., Donnelly, C.A., Anderson, R.M. :
Predicted vCJD mortality in Great Britain - Modelling the latest data puts a ceiling on the likely number of vCJD cases Nature 406:583-584, 2000. Pubmed reference: 10949288. DOI: 10.1038/35020688.
Glavits, R., Tekes, L., Ratz, F. :
Consequences for the veterinarians of the new regulation concerning the control of transmissible spongiform encephalopathies - Addition - Remark [Hungarian] Magyar Allatorvosok Lapja 122:352-353, 2000.
Gravenor, M.B., Cox, D.R., Hoinville, L.J., Hoek, A., McLean, A.R. :
Encephalopathies - Scrapie in Britain during the BSE years Nature 406:584-585, 2000. Pubmed reference: 10949289. DOI: 10.1038/35020692.
Griffin, J. :
Epidemiology of bovine spongiform encephalopathy in Ireland Irish Veterinary Journal 53:529-532, 2000.
Groschup, M.H., Kuczius, T., Junghans, F., Sweeney, T., Bodemer, W., Buschmann, A. :
Characterization of BSE and scrapie strains/isolates Archives of Virology :217-226, 2000.
Hagenaars, T.J., Ferguson, N.M., Donnelly, C.A., Ghani, A.C., Anderson, R.M. :
Feed-borne transmission and case clustering of BSE Proceedings of the Royal Society of London - Series B: Biological Sciences 267:205-215, 2000. Pubmed reference: 10714874. DOI: 10.1098/rspb.2000.0989.
Honig, J.F., Merten, H.A. :
Risk of transmission of agents associated with Creutzfeldt-Jakob disease and bovine spongiform encephalopathy - Reply Plastic & Reconstructive Surgery 105:2274-2275, 2000.
Hope, J. :
Prions and neurodegenerative diseases Current Opinion in Genetics & Development 10:568-574, 2000. Pubmed reference: 10980437.
Jackson, G.S., Clarke, A.R. :