OMIA:001728-34903 : Sex determination in Trachemys scripta (red-eared slider turtle)

In other species: goldfish , northern pike , rainbow trout , Atlantic salmon , guppy , Nile tilapia , Japanese flounder , Atlantic halibut , Gila monster , monocled cobra , Mallard , swan goose , Canada goose , chicken , common quail , turkey , tammar wallaby , ass (donkey) , horse , taurine cattle , sheep , Chinese soft-shelled turtle , jackdaw , petrels , torafugu , whitespotted clarias , ayu , Japanese quail , green-eyed treefrog , derbio , twoband anemonefish , Java barb , clearhead icefish , silver trevally

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 261550 (trait) , 600956 (gene)

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: Shen et al. (2023): "To determine the functional role of Cyp19a1 in turtle ovarian determination, we established loss- and gain-of function models through in ovo lentivirus-mediated genetic manipulation. ... our results suggest that Cyp19a1 is both necessary and sufficient for ovarian determination in the red-eared slider turtle, establishing causality and a direct genetic link between aromatase and reptilian sex determination and differentiation." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2023). OMIA:001728-34903: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2023 Shen, J., Sun, W., Wu, K., Zhuang, T., Lei, J., Ma, Q., Xiao, L., Ge, C. :
Loss- and gain-of-function analyses reveal the essential role of Cyp19a1 in ovarian determination of the red-eared slider turtle. Genetics , 2023. Pubmed reference: 36947451. DOI: 10.1093/genetics/iyad041.

Edit History

  • Created by Imke Tammen2 on 25 Mar 2023
  • Changed by Imke Tammen2 on 25 Mar 2023
  • Changed by Imke Tammen2 on 18 Dec 2023