In other species: goldfish , northern pike , rainbow trout , Atlantic salmon , guppy , Nile tilapia , Japanese flounder , Atlantic halibut , Gila monster , monocled cobra , Mallard , swan goose , Canada goose , chicken , common quail , turkey , tammar wallaby , ass (donkey) , horse , taurine cattle , sheep , Chinese soft-shelled turtle , jackdaw , petrels , torafugu , whitespotted clarias , ayu , Japanese quail , green-eyed treefrog , derbio , twoband anemonefish , Java barb , clearhead icefish , silver trevally

Categories: Reproductive system phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 261550 (trait) , 600956 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: unknown

Considered a defect: no

Species-specific description: Shen et al. (2023): "To determine the functional role of Cyp19a1 in turtle ovarian determination, we established loss- and gain-of function models through in ovo lentivirus-mediated genetic manipulation. ... our results suggest that Cyp19a1 is both necessary and sufficient for ovarian determination in the red-eared slider turtle, establishing causality and a direct genetic link between aromatase and reptilian sex determination and differentiation." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).

Genetic engineering: Yes - variants have been created artificially, e.g. by genetic engineering or gene editing
Have human generated variants been created, e.g. through genetic engineering and gene editing