OMIA 001728-8128 : Sex determination in Oreochromis niloticus

In other species: torafugu , sheep , northern pike

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Year key variant first reported: 2016

Molecular basis: Li et al. (2015): "amhy, a Y-specific duplicate of the anti-Müllerian hormone (amh) gene, induces male sex determination in Nile tilapia. . . . the duplicated amhy with a missense SNP is the candidate sex determining gene and amhy/amhrII signal is essential for male sex determination in Nile tilapia"

Cáceres et al. (2019) confirmed the importance of the amh gene, but did not report any definitive likely causal variants.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
amh anti-Mullerian hormone Oreochromis niloticus LG23 NC_031986.2 (34502800..34498945) amh Homologene, Ensembl, NCBI gene

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2019 Cáceres, G., López, M.E., Cádiz, M.I., Yoshida, G.M., Jedlicki, A.M., Palma-Véjares, R., Travisany, D., Díaz-Domínguez, D., Maass, A., Lhorente, J.P., Soto, J., Salas, D., Yáñez, J.M. :
Fine Mapping Using Whole-Genome Sequencing Confirms Anti-Müllerian Hormone as a Major Gene for Sex Determination in Farmed Nile Tilapia (<i>Oreochromis niloticus</i> L.). G3 (Bethesda) :, 2019. Pubmed reference: 31416805. DOI: 10.1534/g3.119.400297.
2015 Li, M., Sun, Y., Zhao, J., Shi, H., Zeng, S., Ye, K., Jiang, D., Zhou, L., Sun, L., Tao, W., Nagahama, Y., Kocher, T.D., Wang, D. :
A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus. PLoS Genet 11:e1005678, 2015. Pubmed reference: 26588702. DOI: 10.1371/journal.pgen.1005678.

Edit History


  • Created by Frank Nicholas on 31 Oct 2016
  • Changed by Frank Nicholas on 05 Sep 2019