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OMIA:001728-8128 : Sex determination in Oreochromis niloticus (Nile tilapia)

In other species: goldfish , northern pike , rainbow trout , Atlantic salmon , guppy , Japanese flounder , Atlantic halibut , Gila monster , monocled cobra , Mallard , swan goose , Canada goose , chicken , common quail , turkey , tammar wallaby , ass (donkey) , horse , taurine cattle , sheep , Chinese soft-shelled turtle , jackdaw , petrels , torafugu , whitespotted clarias , red-eared slider turtle , ayu , Wuchang bream , water buffalo , Japanese quail , silver arawana , Greenland flounder , green-eyed treefrog , barred knifejaw , derbio , northern snakehead , twoband anemonefish , Java barb , clearhead icefish , Okinawa island spiny rat , Guenther's mouthbrooder , short-snouted icefish , silver trevally

Categories: Reproductive system phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 261550 (trait) , 600956 (gene)

Single-gene trait/disorder: yes

Disease-related: no

Key variant known: no

Year key variant first reported: 2016

Molecular basis: Li et al. (2015): "amhy, a Y-specific duplicate of the anti-Müllerian hormone (amh) gene, induces male sex determination in Nile tilapia. . . . the duplicated amhy with a missense SNP is the candidate sex determining gene and amhy/amhrII signal is essential for male sex determination in Nile tilapia" Cáceres et al. (2019) confirmed the importance of the amh gene, but did not report any definitive likely causal variants.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
amh anti-Mullerian hormone Oreochromis niloticus LG23 NC_031986.2 (34502800..34498945) amh Homologene, Ensembl , NCBI gene

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2019). OMIA:001728-8128: Online Mendelian Inheritance in Animals (OMIA) [dataset]. https://omia.org/. https://doi.org/10.25910/2AMR-PV70

References

Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

2025 Etherington, G., Ciezarek, A., Mehta, T., Barker, T., Durrant, A., Fraser, F., Henderson, S., Irish, N., Kaithakottil, G., Knitlhoffer, V., Ali, S., Trong, T., Watkins, C., Swarbreck, D., Gharbi, K., Benzie, J., Haerty, W. :
Reconstruction of the X and Y haplotypes in the genetically improved Abbassa nile tilapia genome assembly. Sci Rep 15:16057, 2025. Pubmed reference: 40341759. DOI: 10.1038/s41598-025-01300-y.
2024 Qi, S., Dai, S., Zhou, X., Wei, X., Chen, P., He, Y., Kocher, T.D., Wang, D., Li, M. :
Dmrt1 is the only male pathway gene tested indispensable for sex determination and functional testis development in tilapia. PLoS Genet 20:e1011210, 2024. Pubmed reference: 38536778. DOI: 10.1371/journal.pgen.1011210.
2019 Cáceres, G., López, M.E., Cádiz, M.I., Yoshida, G.M., Jedlicki, A.M., Palma-Véjares, R., Travisany, D., Díaz-Domínguez, D., Maass, A., Lhorente, J.P., Soto, J., Salas, D., Yáñez, J.M. :
Fine mapping using whole-genome sequencing confirms Anti-Müllerian hormone as a major gene for sex determination in farmed Nile tilapia (Oreochromis niloticus L.). G3 (Bethesda) 9:3213-3223, 2019. Pubmed reference: 31416805. DOI: 10.1534/g3.119.400297.
2015 Li, M., Sun, Y., Zhao, J., Shi, H., Zeng, S., Ye, K., Jiang, D., Zhou, L., Sun, L., Tao, W., Nagahama, Y., Kocher, T.D., Wang, D. :
A tandem duplicate of anti-Müllerian hormone with a missense SNP on the Y chromosome is essential for male sex determination in nile tilapia, Oreochromis niloticus. PLoS Genet 11:e1005678, 2015. Pubmed reference: 26588702. DOI: 10.1371/journal.pgen.1005678.

Edit History


  • Created by Frank Nicholas on 31 Oct 2016
  • Changed by Frank Nicholas on 05 Sep 2019