OMIA:001728-8128 : Sex determination in Oreochromis niloticus |
In other species: torafugu , sheep , northern pike , horse , ass , clearhead icefish , goldfish , ayu , Japanese quail , silver trevally , chicken , Mallard , common quail , turkey , swan goose , Canada goose , , red-eared slider turtle , cattle , Gila monster , Chinese soft-shelled turtle , Atlantic salmon
Categories: Reproductive system phene
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 261550 (trait) , 600956 (gene)
Links to MONDO diseases: No links.
Mendelian trait/disorder: yes
Considered a defect: no
Key variant known: no
Year key variant first reported: 2016
Molecular basis: Li et al. (2015): "amhy, a Y-specific duplicate of the anti-Müllerian hormone (amh) gene, induces male sex determination in Nile tilapia. . . . the duplicated amhy with a missense SNP is the candidate sex determining gene and amhy/amhrII signal is essential for male sex determination in Nile tilapia"
Cáceres et al. (2019) confirmed the importance of the amh gene, but did not report any definitive likely causal variants.
Associated gene:
| Symbol | Description | Species | Chr | Location | OMIA gene details page | Other Links |
|---|---|---|---|---|---|---|
| amh | anti-Mullerian hormone | Oreochromis niloticus | LG23 | NC_031986.2 (34502800..34498945) | amh | Homologene, Ensembl , NCBI gene |
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
| 2019 | Cáceres, G., López, M.E., Cádiz, M.I., Yoshida, G.M., Jedlicki, A.M., Palma-Véjares, R., Travisany, D., Díaz-Domínguez, D., Maass, A., Lhorente, J.P., Soto, J., Salas, D., Yáñez, J.M. : |
| Fine mapping using whole-genome sequencing confirms Anti-Müllerian hormone as a major gene for sex determination in farmed Nile tilapia (Oreochromis niloticus L.). G3 (Bethesda) :, 2019. Pubmed reference: 31416805 . DOI: 10.1534/g3.119.400297. | |
| 2015 | Li, M., Sun, Y., Zhao, J., Shi, H., Zeng, S., Ye, K., Jiang, D., Zhou, L., Sun, L., Tao, W., Nagahama, Y., Kocher, T.D., Wang, D. : |
| A Tandem Duplicate of Anti-Müllerian Hormone with a Missense SNP on the Y Chromosome Is Essential for Male Sex Determination in Nile Tilapia, Oreochromis niloticus. PLoS Genet 11:e1005678, 2015. Pubmed reference: 26588702 . DOI: 10.1371/journal.pgen.1005678. |
Edit History
- Created by Frank Nicholas on 31 Oct 2016
- Changed by Frank Nicholas on 05 Sep 2019