OMIA:000201-10053 : Coat colour, agouti in Microtus

In other species: horse , cattle , red fox , pig , sheep , domestic cat , rabbit , dog , gray wolf , coyote , goat , Eurasian water mole , Northern mole vole , North American deer mouse , alpaca , leopard , Asiatic golden cat , leopard cat , ass , impala , Colocolo , Kodkod , Arabian camel , Mongolian gerbil , domestic guinea pig , Western roe deer , llama , oldfield mouse

Categories: Pigmentation phene

Possibly relevant human trait(s) and/or gene(s)s (MIM numbers): 611742 (trait) , 600201 (gene)

Links to MONDO diseases: No links.

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: no

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.

1996 Bazhan, N.M., Yakovleva, T.V., Makarova, E.N. :
Reproduction in the water vole (arvicola terrestris), polymorphic for the agouti locus [Russian] Genetika 32:1125-1130, 1996. Pubmed reference: 8964483 .
1991 Prasolova, L.A., Bazhan, N.M., Vsevolodov, E.B., Latypov, I.F. :
[Verification of the color genotype based on morphological analysis of fur pigmentation of brown and black water voles Arvicola terrestris L]. Genetika 27:1423-30, 1991. Pubmed reference: 1761214 .

Edit History

  • Created by Frank Nicholas on 06 Sep 2005
  • Changed by Frank Nicholas on 23 Oct 2011