OMIA 000201-10053 : Coat colour, agouti in Microtus |
In other species:
horse
,
cattle
,
red fox
,
pig
,
sheep
,
domestic cat
,
rabbit
,
dog
,
gray wolf
,
coyote
,
goat
,
Eurasian water mole
,
Northern mole vole
,
North American deer mouse
,
alpaca
,
leopard
,
Asiatic golden cat
,
leopard cat
,
ass
,
impala
,
Colocolo
,
Kodkod
,
Arabian camel
,
Mongolian gerbil
,
domestic guinea pig
,
Western roe deer
,
llama
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
611742 (trait)
,
600201 (gene)
Mendelian trait/disorder:
yes
Considered a defect:
no
Key variant known:
no
Cross-species summary:
This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus.
As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
1996 | Bazhan, N.M., Yakovleva, T.V., Makarova, E.N. : | |
Reproduction in the water vole (arvicola terrestris), polymorphic for the agouti locus [Russian] Genetika 32:1125-1130, 1996. Pubmed reference: 8964483. | ||
1991 | Prasolova, L.A., Bazhan, N.M., Vsevolodov, E.B., Latypov, I.F. : | |
[Verification of the color genotype based on morphological analysis of fur pigmentation of brown and black water voles Arvicola terrestris L]. Genetika 27:1423-30, 1991. Pubmed reference: 1761214. |
Edit History
- Created by Frank Nicholas on 06 Sep 2005
- Changed by Frank Nicholas on 23 Oct 2011