OMIA 000201-9612 : Coat colour, agouti in Canis lupus |
In other species:
horse
,
cattle
,
meadow voles
,
red fox
,
pig
,
sheep
,
domestic cat
,
rabbit
,
dog
,
coyote
,
goat
,
Eurasian water mole
,
Northern mole vole
,
North American deer mouse
,
alpaca
,
leopard
,
Asiatic golden cat
,
leopard cat
,
ass
,
impala
,
Colocolo
,
Kodkod
,
Arabian camel
,
Mongolian gerbil
,
domestic guinea pig
,
Western roe deer
,
llama
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
611742 (trait)
,
600201 (gene)
Mendelian trait/disorder:
yes
Considered a defect:
no
Key variant known:
no
Cross-species summary:
This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus.
As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".
Molecular basis:
Schmutz et al. (2007) documented polymorphisms in the ASIP gene of wolves and coyotes, some of which are shared by dogs.
Reference
2007 | Schmutz, SM., Berryere, TG., Barta, JL., Reddick, KD., Schmutz, JK. : | |
Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization. J Hered 98:351-5, 2007. Pubmed reference: 17630272. DOI: 10.1093/jhered/esm036. |
Edit History
- Created by Frank Nicholas on 20 Nov 2010
- Changed by Frank Nicholas on 12 Sep 2011
- Changed by Frank Nicholas on 12 Oct 2011
- Changed by Frank Nicholas on 12 Dec 2011
- Changed by Frank Nicholas on 21 Mar 2012
- Changed by Frank Nicholas on 21 Jun 2013