OMIA 000201-9793 : Coat colour, agouti in Equus asinus
From a survey of 283 donkeys, Yu et al. (2020) reported "Donkeys homozygous for the ASIP [c.349]T‐allele all have light points, which are missing in all homozygous C‐allele genotype at c.349T>C (CC) animals . . . However, 27.8% of the NLP [no light points] donkeys are heterozygous, which has not been found previously. . . . The variable phenotypes of ASIP heterozygotes and of ASIP TT homozygotes indicate the involvement of one or more other genes that so far have not been identified."Associated gene:
|Symbol||Description||Species||Chr||Location||OMIA gene details page||Other Links|
|ASIP||agouti signaling protein||Equus asinus||15||NC_052191.1 (25292944..25410462)||ASIP||Homologene, Ensembl, NCBI gene|
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WARNING! Inclusion of a variant in this table does not automatically mean that it should be used for DNA testing. Anyone contemplating the use of any of these variants for DNA testing should examine critically the relevant evidence (especially in breeds other than the breed in which the variant was first described). If it is decided to proceed, the location and orientation of the variant sequence should be checked very carefully.
Since October 2021, OMIA includes a semiautomated lift-over pipeline to facilitate updates of genomic positions to a recent reference genome position. These changes to genomic positions are not always reflected in the ‘acknowledgements’ or ‘verbal description’ fields in this table.
|OMIA Variant ID||Breed(s)||Variant Phenotype||Gene||Allele||Type of Variant||Source of Genetic Variant||Reference Sequence||Chr.||g. or m.||c. or n.||p.||Verbal Description||EVA ID||Inferred EVA rsID||Year Published||PubMed ID(s)||Acknowledgements|
|149||No light points||ASIP||NLP||missense||Naturally occurring variant||c.349T>C||p.(C117R)||2015||25887951|
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
|2020||Yu, Y., Shang, S., Zhang, X., Wang, Z., Dang, W., Zhang, J., Zhu, Y., Dang, R., Irwin, D.M., Zhang, S. :|
|A missense mutation in ASIP is associated with light point variation in donkeys. Anim Genet :, 2020. Pubmed reference: 32311147. DOI: 10.1111/age.12940.|
|2017||Sun, T., Li, S., Xia, X., Ji, C., Shen, S., Zhang, G., Yu, J., Jiang, G., Dang, R., Lei, C. :|
|ASIP gene variation in Chinese donkeys. Anim Genet 48:372-373, 2017. Pubmed reference: 28198029. DOI: 10.1111/age.12530.|
|2015||Abitbol, M., Legrand, R., Tiret, L. :|
|A missense mutation in the agouti signaling protein gene (ASIP) is associated with the no light points coat phenotype in donkeys. Genet Sel Evol 47:28, 2015. Pubmed reference: 25887951. DOI: 10.1186/s12711-015-0112-x.|
- Created by Frank Nicholas on 16 Apr 2015
- Changed by Frank Nicholas on 16 Apr 2015
- Changed by Frank Nicholas on 02 Sep 2017
- Changed by Frank Nicholas on 24 Apr 2020