OMIA 000201-329620 : Coat colour, agouti in Ellobius talpinus |
In other species:
horse
,
cattle
,
meadow voles
,
red fox
,
pig
,
sheep
,
domestic cat
,
rabbit
,
dog
,
gray wolf
,
coyote
,
goat
,
Eurasian water mole
,
North American deer mouse
,
alpaca
,
leopard
,
Asiatic golden cat
,
leopard cat
,
ass
,
impala
,
Colocolo
,
Kodkod
,
Arabian camel
,
Mongolian gerbil
,
domestic guinea pig
,
Western roe deer
,
llama
Possibly relevant human trait(s) and/or gene(s)s (MIM numbers):
611742 (trait)
,
600201 (gene)
Mendelian trait/disorder:
yes
Mode of inheritance:
Autosomal
Considered a defect:
no
Key variant known:
no
Cross-species summary:
This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus.
As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".
Reference
2005 | Cheprakov, M.I., Evdokimov, N.G., Glotov, N.V. : | |
[Inheritance of coat color in the mole vole (Ellobius talpinus Pallas)]. Genetika 41:1552-8, 2005. Pubmed reference: 16358722. |
Edit History
- Created by Frank Nicholas on 23 Oct 2011