OMIA 000201-9925 : Coat colour, agouti in Capra hircus

In other species: horse , cattle , meadow voles , red fox , pig , sheep , domestic cat , rabbit , dog , gray wolf , coyote , Eurasian water mole , Northern mole vole , North American deer mouse , alpaca , leopard , Asiatic golden cat , leopard cat , ass , impala , Colocolo , Kodkod , Geoffroy's cat , Arabian camel , Mongolian gerbil

Possibly relevant human trait(s) and/or gene(s) (MIM number): 611742

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: no

Key variant known: no

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus.

Molecular basis: Despite many investigations of association between nucleotide polymorphism at the ASIP locus and coat colour in goats, we do not yet have any concrete evidence of a particular coat colour in goats being due to a particular mutation in the ASIP gene in this species.

References


Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2017 Martin, P.M., Palhière, I., Ricard, A., Tosser-Klopp, G., Rupp, R. :
Correction: Genome Wide Association Study Identifies New Loci Associated with Undesired Coat Color Phenotypes in Saanen Goats. PLoS One 12:e0186029, 2017. Pubmed reference: 28982168. DOI: 10.1371/journal.pone.0186029.
2016 Martin, P.M., Palhière, I., Ricard, A., Tosser-Klopp, G., Rupp, R. :
Genome Wide Association Study Identifies New Loci Associated with Undesired Coat Color Phenotypes in Saanen Goats. PLoS One 11:e0152426, 2016. Pubmed reference: 27030980. DOI: 10.1371/journal.pone.0152426.
2013 Adefenwa, M.A., Peters, S.O., Agaviezor, B.O., Wheto, M., Adekoya, K.O., Okpeku, M., Oboh, B., Williams, G.O., Adebambo, O.A., Singh, M., Thomas, B., De Donato, M., Imumorin, I.G. :
Identification of single nucleotide polymorphisms in the agouti signaling protein (ASIP) gene in some goat breeds in tropical and temperate climates. Mol Biol Rep 40:4447-57, 2013. Pubmed reference: 23661018. DOI: 10.1007/s11033-013-2535-1.
2011 Badaoui, B., D'Andrea, M., Pilla, F., Capote, J., Zidi, A., Jordana, J., Ferrando, A., Delgado, J.V., Martínez, A., Vidal, O., Amills, M. :
Polymorphism of the goat agouti signaling protein gene and its relationship with coat color in Italian and Spanish breeds. Biochem Genet 49:523-32, 2011. Pubmed reference: 21373989. DOI: 10.1007/s10528-011-9427-7.
2010 Li, X.L., Zhao, J.W., Tang, C.J., Zhou, R.Y., Zheng, G., Li, L.H., Guo, X.L. :
Sequencing of part of the goat agouti gene and SNP identification. Biochem Genet 48:152-6, 2010. Pubmed reference: 20094847. DOI: 10.1007/s10528-009-9307-6.
2009 Fontanesi, L., Beretti, F., Riggio, V., Gómez González, E., Dall'Olio, S., Davoli, R., Russo, V., Portolano, B. :
Copy number variation and missense mutations of the agouti signaling protein (ASIP) gene in goat breeds with different coat colors. Cytogenet Genome Res 126:333-47, 2009. Pubmed reference: 20016133. DOI: 10.1159/000268089.
2008 Tang, C.J., Zhou, R.Y., Li, X.L., Zhao, J.W., Li, L.H., Feng, F.J., Li, D.F., Wang, J.T., Guo, X.L., Keng, J.F. :
Variation of 423G>T in the Agouti gene exon 4 in indigenous chinese goat breeds. Biochem Genet 46:770-80, 2008. Pubmed reference: 18792776. DOI: 10.1007/s10528-008-9192-4.
1994 Adalsteinsson, S., Sponenberg, D.P., Alexieva, S., Russel, A.J.F. :
Inheritance of goat coat colors Journal of Heredity 85:267-272, 1994. Pubmed reference: 7930499.

Edit History


  • Created by Frank Nicholas on 10 Sep 2011
  • Changed by Frank Nicholas on 10 Sep 2011
  • Changed by Frank Nicholas on 17 Oct 2011
  • Changed by Frank Nicholas on 05 Aug 2013