OMIA:000201-9305 : Coat colour, agouti in Sarcophilus harrisii (Tasmanian devil)

In other species: gray wolf , coyote , dog , red fox , domestic cat , leopard , ass (donkey) , horse , pig , Arabian camel , llama , Western roe deer , impala , taurine cattle , goat , sheep , rabbit , tassel-eared squirrel , North American deer mouse , Mongolian gerbil , meadow voles , domestic guinea pig , alpaca , leopard cat , oldfield mouse , Kodkod , Colocolo , Asiatic golden cat , Northern mole vole , Eurasian water mole

Categories: Pigmentation phene

Links to possible relevant human trait(s) and/or gene(s) in OMIM: 611742 (trait) , 600201 (gene)

Mendelian trait/disorder: yes

Considered a defect: no

Key variant known: yes

Year key variant first reported: 2024

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".

Markers: Hartley et al. (2024) investigated the marked difference in coat colour and patterning between two closely realted species, quolls and Tasmanian devils. Their comparative analysis of core pigmentation loci across the genomes of both species revealed the probable basis of pelage variation between these two species as a species specific deletion of exon 1 of ASIP in Tasmanian devils.

Associated gene:

Symbol Description Species Chr Location OMIA gene details page Other Links
ASIP Sarcophilus harrisii - no genomic information (-..-) ASIP Ensembl

Cite this entry

Nicholas, F. W., Tammen, I., & Sydney Informatics Hub. (2024). OMIA:000201-9305: Online Mendelian Inheritance in Animals (OMIA) [dataset].


2024 Hartley, G.A., Frankenberg, S.R., Robinson, N.M., MacDonald, A.J., Hamede, R.K., Burridge, C.P., Jones, M.E., Faulkner, T., Shute, H., Rose, K., Brewster, R., O'Neill, R.J., Renfree, M.B., Pask, A.J., Feigin, C.Y. :
Genome of the endangered eastern quoll (Dasyurus viverrinus) reveals signatures of historical decline and pelage color evolution. Commun Biol 7:636, 2024. Pubmed reference: 38796620. DOI: 10.1038/s42003-024-06251-0.

Edit History

  • Created by Imke Tammen2 on 28 May 2024
  • Changed by Imke Tammen2 on 28 May 2024