Categories: Pigmentation phene

Possible human homologues (MIM numbers): 611742 (trait) , 600201 (gene)

Cross-species summary: This locus, ASIP, encodes the agouti signalling protein, a peptide antagonist of the melanocyte-stimulating hormone receptor (MC1R), which is the product of the extension locus. As explained by Schneider et al. (PLoS Genet 10(2): e1004892; 2015), "The most common causes of melanism (black coat) mutations are gain-of-function alterations in MC1R, or loss-of function alterations in ASIP, which encodes Agouti signaling protein, a paracrine signaling molecule that inhibits MC1R signaling".

Species in which this phene is found:
Tasmanian devil (Sarcophilus harrisii)
common brushtail possum (Trichosurus vulpecula)
gray wolf (Canis lupus)
coyote (Canis latrans)
dog (Canis lupus familiaris)
red fox (Vulpes vulpes)
domestic cat (Felis catus)
leopard (Panthera pardus)
ass (donkey) (Equus asinus)
horse (Equus caballus)
pig (Sus scrofa)
Arabian camel (Camelus dromedarius)
llama (Lama glama)
Western roe deer (Capreolus capreolus)
impala (Aepyceros melampus)
taurine cattle (Bos taurus)
goat (Capra hircus)
sheep (Ovis aries)
rabbit (Oryctolagus cuniculus)
tassel-eared squirrel (Sciurus aberti)
North American deer mouse (Peromyscus maniculatus)
Mongolian gerbil (Meriones unguiculatus)
meadow voles (Microtus)
domestic guinea pig (Cavia porcellus)
fallow deer (Dama dama)
alpaca (Vicugna pacos)
leopard cat (Prionailurus bengalensis)
oldfield mouse (Peromyscus polionotus)
Kodkod (Leopardus guigna)
Colocolo (Leopardus colocolo)
Asiatic golden cat (Catopuma temminckii)
Northern mole vole (Ellobius talpinus)
Eurasian water mole (Arvicola amphibius)